Re: [NMusers] The system cannot execute the specified program

[Nick Holford]

Tom, The SIZES for 'big' NM7 show that the max number of THETA is 70, max number of ETA+EPS is 70 and LPAR is 195. Can you explain why LPAR is 195 and not simply the sum of LTH + LVR? Is this to allow for estimation of off-diagonal elements of OMEGA and SIGMA? Can you confirm that one can set LTH and LVR to values greater than 70 to accommodate problems with more parameters? Nick ! LTH: MAX. NO. OF THETA'S ! IF LTH IS CHANGED, ALSO RECOMPILE PREDPP, NM-TRAN, NM-TRAN LIBRARY       PARAMETER (LTH=70) ! TL 4/22/09 ! LVR: MAX. NO. OF ETA'S + EPS'S ! IF LVR IS CHANGED, ALSO RECOMPILE PREDPP, NM-TRAN, NM-TRAN LIBRARY       PARAMETER (LVR=70) ! TL 4/22/09 ! LVR2: MAX. NO. OF ETA'S PERMITTED WHEN LAPLACIAN METHOD IS USED ! IF LVR2 IS CHANGED, ALSO RECOMPILE NMTRAN       PARAMETER (LVR2=70) ! TL 4/22/09 ! LPAR: MAX. NO. OF PARAMETERS THAT MAY BE ESTIMATED       PARAMETER (LVRM=MAX(LVR,LVR2))        ! Bauer !     PARAMETER (LPAR=LTH+((LVRM+1)*LVRM)/2)       PARAMETER (LPAR=195) ! TL 4/22/09 Ludden, Thomas wrote: Based on limited experience with the sizing of variables in SIZES for NONMEM 7.1.0, some known determinants of memory usage are the maximum number of observations per individual, NO, the maximum number of individuals, MAXIDS, and the maximum number of estimated parameters, LPAR.  The dimensions of many arrays are determined by these values.  There are likely to be other important determinants as well.    For the "reg" version of SIZES: NO: 250 MAXIDS: 10000 LPAR: 70   For the "big" version: NO: 500 MAXIDS: 15000 LPAR: 195   We will do a more systematic investigation of this issue and will report the results when they are available.   Bob Bauer is working with Nous Infosystems to explore the practicality of allocating memory for selected variables at the beginning of a problem based on the specific needs of the problem.  A future version may incorporate this capability.   Tom Thomas M. Ludden Ph.D. Vice-President, Pharmacometrics R&D ICON Development Solutions Tel: + 1 410 696 3040 Mob: + 1  410 258 2411 Fax:  + 1 410 480 0776 Email: thomas.lud...@iconplc.com Web: www.icondevsolutions.com       From: Jurgen Bulitta [mailto:jbuli...@ordwayresearch.org] Sent: Saturday, October 17, 2009 10:59 PM To: Ludden, Thomas; non...@optonline.net Cc: nmusers@globomaxnm.com Subject: RE: [NMusers] The system cannot execute the specified program Dear Tom, Dear All,   For those of us who prefer project specific NONMEM installations to save estimation time, it might be helpful, if ICON can provide some rough guidance on the main contributor to the RAM needs of NONMEM 7. I.e. is it primarily the number of observations, compartments, thetas, omegas, or another variable or some function of these variables?   The following might be very cumbersome: Would it be possible to include a switch during the installation which disables certain NONMEM 7 features to save RAM. (I recognize that this might cause a lot of unpredictable software issues.) Dual CPU servers currently have around 8-18 RAM slots. 2 and 4 GB RAM chips are reasonably priced. Thus, on the 64-bit server side, this is probably a minor issue.   Best wishes Juergen         From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Ludden, Thomas Sent: Friday, October 16, 2009 3:14 PM To: non...@optonline.net Cc: nmusers@globomaxnm.com Subject: RE: [NMusers] The system cannot execute the specified program   Pavel,   The message you describe is usually the result of not having enough memory available for the NONMEM 7 memory image.  If you are using the "big" version of SIZES you may need about 1.6-2 GB of available memory for each job.  For the efficient use of NONMEM 7's  new methods more variables are now stored in memory than was the case for NONMEM VI.  The memory image is larger even if one is not using the new methods.  When using NONMEM 7 and the "reg" SIZES, I have been able to run 8 jobs simultaneously on a dual processor dual core machine, but only 3-4 jobs when using the "big" version of SIZES depending upon what else is running.  I have 3 GB of memory and the task manager indicates a maximum of about 7.4 GB via paging.   Tom Thomas M. Ludden Ph.D. Vice-President, Pharmacometrics R&D ICON Development Solutions Tel: + 1 410 696 3040 Mob: + 1  410 258 2411 Fax:  + 1 410 480 0776 Email: thomas.lud...@iconplc.com Web: www.icondevsolutions.com   From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of non...@optonline.net Sent: Friday, October 16, 2009 2:02 PM To: non...@optonline.net Cc: nmusers@globomaxnm.com Subject: [NMusers] The system cannot execute the specified program > Hello NONMEM Users, > We have a computer with 4 processors. When I try to run more > than 3 NONMEM7 jobs, I am getting the following message: > Starting nonmem execution ... > The system cannot execute the specified program. > KP9022.OUT > newline > 1 file(s) copied. > Could Not Find H:\4\output > > The message is code and directory independent. It always > appears when I try to run more than 3 codes. When I test > nonmem7 using a laptop, which also has 4 processors, I can > execute 4 programs. Also, when I had NONMEM6, I did not have > this problem on the same machine. > Do you familiar with this problem? Thanks. > Pavel > ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835   ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835 -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand n.holf...@auckland.ac.nz tel:+64(9)923-6730 fax:+64(9)373-7090 mobile: +64 21 46 23 53 http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford