Re: [NMusers] The system cannot execute the specified program

[Nick Holford]

Juergen, I'd be interested to know of your experience of how much estimation time you save by making project specific installations. Given that you must take additional time to setup SIZES and recompile NONMEM for each project (say 10-15 minutes) how much time do you save per run compared with having regular and big installations of NONMEM? Nick Jurgen Bulitta wrote: Dear Tom, Dear All,   For those of us who prefer project specific NONMEM installations to save estimation time, it might be helpful, if ICON can provide some rough guidance on the main contributor to the RAM needs of NONMEM 7. I.e. is it primarily the number of observations, compartments, thetas, omegas, or another variable or some function of these variables?   The following might be very cumbersome: Would it be possible to include a switch during the installation which disables certain NONMEM 7 features to save RAM. (I recognize that this might cause a lot of unpredictable software issues.) Dual CPU servers currently have around 8-18 RAM slots. 2 and 4 GB RAM chips are reasonably priced. Thus, on the 64-bit server side, this is probably a minor issue.   Best wishes Juergen         From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Ludden, Thomas Sent: Friday, October 16, 2009 3:14 PM To: non...@optonline.net Cc: nmusers@globomaxnm.com Subject: RE: [NMusers] The system cannot execute the specified program   Pavel,   The message you describe is usually the result of not having enough memory available for the NONMEM 7 memory image.  If you are using the "big" version of SIZES you may need about 1.6-2 GB of available memory for each job.  For the efficient use of NONMEM 7's  new methods more variables are now stored in memory than was the case for NONMEM VI.  The memory image is larger even if one is not using the new methods.  When using NONMEM 7 and the "reg" SIZES, I have been able to run 8 jobs simultaneously on a dual processor dual core machine, but only 3-4 jobs when using the "big" version of SIZES depending upon what else is running.  I have 3 GB of memory and the task manager indicates a maximum of about 7.4 GB via paging.   Tom Thomas M. Ludden Ph.D. Vice-President, Pharmacometrics R&D ICON Development Solutions Tel: + 1 410 696 3040 Mob: + 1  410 258 2411 Fax:  + 1 410 480 0776 Email: thomas.lud...@iconplc.com Web: www.icondevsolutions.com   From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of non...@optonline.net Sent: Friday, October 16, 2009 2:02 PM To: non...@optonline.net Cc: nmusers@globomaxnm.com Subject: [NMusers] The system cannot execute the specified program > Hello NONMEM Users, > We have a computer with 4 processors. When I try to run more > than 3 NONMEM7 jobs, I am getting the following message: > Starting nonmem execution ... > The system cannot execute the specified program. > KP9022.OUT > newline > 1 file(s) copied. > Could Not Find H:\4\output > > The message is code and directory independent. It always > appears when I try to run more than 3 codes. When I test > nonmem7 using a laptop, which also has 4 processors, I can > execute 4 programs. Also, when I had NONMEM6, I did not have > this problem on the same machine. > Do you familiar with this problem? Thanks. > Pavel > ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835   -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand n.holf...@auckland.ac.nz tel:+64(9)923-6730 fax:+64(9)373-7090 mobile: +64 21 46 23 53 http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford