Batul,
With the addition of an EVID variable, both methods should work. If you can assume that the system is at steady-state, it may be more efficient to use the SS data item rather than individual doses to bring the system up to the point of the first sample. Cheers. Brian Brian M. Sadler, Ph.D. Strategic PK Consulting, LLC 1209 Seabrook Avenue Cary, North Carolina 27511 USA <mailto:[EMAIL PROTECTED]> [EMAIL PROTECTED] +1 (919) 523-5485 (mobile) +1 (508) 408-0250 (fax) From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Batul Parta Sent: Wednesday, November 12, 2008 10:36 AM To: [email protected] Subject: [NMusers] Use of ADDL and II Dear All, I am modeling a repeated dosing study. Subjects were given twice daily doses for 8 weeks and a number of samples were taken on the last day of dosing. There were also sparse samples taken at weeks 2, 4, and 6. I want to use ADDL and II for the dosing scheme. Can I lump all doses into one line or do I have to stop the dosing record prior to each sample and re-start again? In other words, will the following file structure work: ID TIME AMT ADDL II DV 1 0 10 112 12 0 1 143 0 0 0 124 1 287 0 0 0 131 . . . Or do I have to use the following: ID TIME AMT ADDL II DV 1 0 10 14 12 0 1 143 0 0 0 124 1 144 10 14 12 0 1 287 0 0 0 131 . . . Thank you in advance. BP
