After spending an entire morning having much the same problem as the original poster, I can confirm that moving everything into a brand new project solves the issue.
In my case, I had not touched my Android code in 2 months. Debugging definitely worked back then, but upon opening the project last week and upgrading to latest stable Mono for Android, breakpoints were then just permanently disabled. Clearly something in the proj file got changed/broken between releases. Anyhow I've got debugging back thankfully (albeit by having to completely move all my stuff into the new project). -- View this message in context: http://mono-for-android.1047100.n5.nabble.com/debugger-breakpoints-4-4-41-tp5712641p5712759.html Sent from the Mono for Android mailing list archive at Nabble.com. _______________________________________________ Monodroid mailing list Monodroid@lists.ximian.com UNSUBSCRIBE INFORMATION: http://lists.ximian.com/mailman/listinfo/monodroid