Don't know what your budget / license contstraints are, but on the pricier side Lotus Domino Enterprise has excellent clustering capabilities with real-time replication and synchronization. Runs on Windows, Linux (i386, IBM zSeries and s/390, I've made it run on SLES 9 AMD64 but this is not officially supported), zOS, OS/400, AIX, and Solaris. Supports POP, IMAP, and Web mail. If you use their client software, it has automatic and user-transparent failover.
That being said, it'd be fascinated in hearing about any successes you have with clustered F/OSS solutions.
Regards,
Erik Carlseen
I'm sorry I didn't mention it earlier, we use NetQMAIL + VPOPMAIL + mysql
centralized auth.
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