Thanks a lot JMarc and Günter for your interesting explanations!
I've tried now the LatinModern font which works indeed better.
Also changing the encoding to OT1 worked (if I don't want to search for
Umlauts ;-) )
Sorry that I have posted my question to lyx-devel and not lyx-user, but
the reason was to suggest to make it possible to deselect the package
fontenc. And I still think that all packages should be deselectable. But
my specific problem for the moment is solved, so thanks a lot.

- Sebastian 

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