There may also be a problem with the assembly manifests.
Can someone who has problems with LyX 1.4.3 on Windows try to install: http://www.microsoft.com/downloads/details.aspx?FamilyId=32BC1BEE-A3F9-4C13-9C99-220B62A191EE&displaylang=en and report whether this solves the problem? Joost