Hi Ricardo, Thanks for your reply!
> This works for me. I have configured berlin.guixsd.org with two network > interfaces by simply providing static-networking-service twice. I’m not > removing any services from %base-services: > > (services (cons* … > (static-networking-service "enp6s4f0" > "141.80.181.40" > #:netmask "255.255.255.0" > #:gateway "141.80.181.1") OK, so my first try was right but my interpretation of the error message wasn't. After some further exploration, the already-running network service is indeed not the statically configured loopback, but (dhcp-client-service), which handles all network adapters other than loopback. Configuring both of my adapters with static IPs works very well, but is not practical for a laptop used in different networks. Back to rethinking my deployment strategy... Konrad.