Hi, all: I'm trying to embed cholesterol molecules into a DOPC bilayer in a coarse grained model. The force field and coordinates for a pure DOPC bilayer and for cholesterol were obtained on the MARTINI's site. I randomly replace a DOPC molecule with a cholesterol molecule and do the energy minimization. After embedded a certain amount of cholesterols, I run the simulation by coupling DOPC and CHOL together to a thermostat. However, the cholesterols turn to be very unstable and flip-flop a lot between the monolayers, which I think is not expected. Any suggestions will be greatly appreciated.Thank you. dj
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