https://gcc.gnu.org/bugzilla/show_bug.cgi?id=89435
--- Comment #2 from Jakub Jelinek <jakub at gcc dot gnu.org> --- In particular, the wrong combination is I think: Trying 77 -> 78: 77: r164:SI=r125:QI#0&0xff REG_DEAD r125:QI 78: r124:SI=r164:SI+r162:SI REG_DEAD r164:SI REG_DEAD r162:SI Successfully matched this instruction: (set (reg:SI 124 [ _15 ]) (plus:SI (reg:SI 162) (subreg:SI (reg:QI 125 [ _18 ]) 0))) That is simply not equivalent, even if we know that the value assigned to pseudo 125 is constant 0xff and we loaded it into SImode register somewhere.