Good find, thanks! "you can see a lot just by looking" - yogi berra > From the 1st link: >> Producing highly purified preparations containing a high titer of >> neutralizing antibodies against SARS2-CoV-2 is preferable to convalescent >> sera given that these are safer and have higher activity. Unfortunately, >> such preparations will not be available for many months, whereas locally >> produced convalescent sera could be available much sooner. >> >> [...] At this time, we do not know what an effective neutralizing titer >> would be in a susceptible individual given passive antibody therapy for >> prophylaxis, and determining this parameter would be part of the study >> design. Similarly, we do not know what doses would be effective >> therapeutically. We do know that when convalescent serum was used to prevent >> measles or mumps the amounts used were in the order of 10–40 cc (10, 11). In >> contrast, when convalescent serum was used to treat severe disease in >> soldiers with 1918 influenza, the amounts given were in the hundreds of >> milliliters (34). These older studies claimed efficacy even though >> convalescent serum was given without any knowledge of neutralizing titers. >> Those experiences suggest that even small amounts of antibody may prevent >> and/or treat infection. Hence, we can anticipate that effective prophylactic >> doses would be much smaller than therapeutic doses. This makes sense, since >> the infecting inoculum is likely to be much smaller than the viral burden >> during severe disease. > > > On 3/23/20 6:15 PM, Steven A Smith wrote: >> Glen> The convalescent sera option for containing COVID-19 >> https://www.jci.org/articles/view/138003 >> >> Barry> >> https://www.globalhealthnow.org/2020-03/covid-19s-stop-gap-solution-until-vaccines-and-antivirals-are-ready >> [...] >> I didn't see what dosage of plasma is considered remedial or prophylactic. >> Is it one-to-one? A pint per patient? I think plasma donors can give a >> pint weekly or more often?
============================================================ FRIAM Applied Complexity Group listserv Meets Fridays 9a-11:30 at cafe at St. John's College to unsubscribe http://redfish.com/mailman/listinfo/friam_redfish.com archives back to 2003: http://friam.471366.n2.nabble.com/ FRIAM-COMIC http://friam-comic.blogspot.com/ by Dr. Strangelove
