From the 1st link: > Producing highly purified preparations containing a high titer of > neutralizing antibodies against SARS2-CoV-2 is preferable to convalescent > sera given that these are safer and have higher activity. Unfortunately, such > preparations will not be available for many months, whereas locally produced > convalescent sera could be available much sooner. > > [...] At this time, we do not know what an effective neutralizing titer would > be in a susceptible individual given passive antibody therapy for > prophylaxis, and determining this parameter would be part of the study > design. Similarly, we do not know what doses would be effective > therapeutically. We do know that when convalescent serum was used to prevent > measles or mumps the amounts used were in the order of 10–40 cc (10, 11). In > contrast, when convalescent serum was used to treat severe disease in > soldiers with 1918 influenza, the amounts given were in the hundreds of > milliliters (34). These older studies claimed efficacy even though > convalescent serum was given without any knowledge of neutralizing titers. > Those experiences suggest that even small amounts of antibody may prevent > and/or treat infection. Hence, we can anticipate that effective prophylactic > doses would be much smaller than therapeutic doses. This makes sense, since > the infecting inoculum is likely to be much smaller than the viral burden > during severe disease.
On 3/23/20 6:15 PM, Steven A Smith wrote: > Glen> The convalescent sera option for containing COVID-19 > https://www.jci.org/articles/view/138003 > > Barry> > https://www.globalhealthnow.org/2020-03/covid-19s-stop-gap-solution-until-vaccines-and-antivirals-are-ready > [...] > I didn't see what dosage of plasma is considered remedial or prophylactic. > Is it one-to-one? A pint per patient? I think plasma donors can give a > pint weekly or more often? -- ☣ uǝlƃ ============================================================ FRIAM Applied Complexity Group listserv Meets Fridays 9a-11:30 at cafe at St. John's College to unsubscribe http://redfish.com/mailman/listinfo/friam_redfish.com archives back to 2003: http://friam.471366.n2.nabble.com/ FRIAM-COMIC http://friam-comic.blogspot.com/ by Dr. Strangelove
