Thanks for your guidance. I already tried recon-all-clinical.sh; however, I was 
wondering why did this happen? Could it be related to resampling process or the 
orientation?

Thanks,
Nima
________________________________
From: freesurfer-boun...@nmr.mgh.harvard.edu 
<freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of Douglas N. Greve 
<dgr...@mgh.harvard.edu>
Sent: Tuesday, January 28, 2025 12:41 PM
To: freesurfer@nmr.mgh.harvard.edu <freesurfer@nmr.mgh.harvard.edu>
Subject: Re: [Freesurfer] Issue with Right Hemisphere Segmentation/Parcellation

Try using recon-all-clinical.sh; it works a lot better on these thick slice data


On 1/28/2025 12:24 PM, Taghizadeh Mortezaei, Nima wrote:
Hello FreeSurfer Developers and Community,

I am working with an axial T1-weighted post-contrast MRI, with an original 
voxel size of 1×1×5.5 mm. I resampled this MRI in 3D Slicer using B-Spline 
interpolation and then saved it as a mgz file. After running recon-all on this 
resampled file, I noticed that the right hemisphere’s segmentation and 
parcellation are flawed. Also, considering the age and health situation of this 
patient, i believe the WM hypointensities are overestimated in the left 
hemisphere.

I am using the following version of FreeSurfer: 
freesurfer-macOS-darwin_x86_64-7.4.1-20230614-7eb8460.
The command line was:
recon-all -s 12th_recon_output -i input.mgz -all -parallel -openmp 12

I’ve attached the recon-all log file, a screenshot from Freeview to illustrate 
the issue, and mri_info file. I would greatly appreciate any guidance, 
troubleshooting advice, or suggestions on what might have gone wrong and how to 
correct this issue.

Thank you in advance for your help!

Best regards,
Nima



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