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Hello,

I am not sure if there is a right or wrong here; personally, I'd do a single 
whole-brain analysis, and apply ROIs only as the very last step, correcting for 
multiple comparisons within each ROI and for the number of ROIs. I would not 
expect fundamental differences between this approach and your approach, though.

FDR2 may be more sensitive than FDR, but not necessarily in all circumstances.

Hope this helps,

Kersten


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Hello FreeSurfer experts,

I am using a mass-univariate pipeline to assess cortical thickness changes 
longitudinally at a regional level (based on the D-K atlas), and have been 
following this thread: MailScanner has detected a possible fraud attempt from 
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My pipeline is set up so that lme_mass_fit, lme_mass_F, and lme_mass_FDR are 
all run independently in a for-loop for each individual ROI, rather than 
altogether. Is this correct? As well, would using FDR2 be more advantageous 
than FDR?


Best,
Daniel Bondi
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