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I am not sure if there is a right or wrong here; personally, I'd do a single whole-brain analysis, and apply ROIs only as the very last step, correcting for multiple comparisons within each ROI and for the number of ROIs. I would not expect fundamental differences between this approach and your approach, though. FDR2 may be more sensitive than FDR, but not necessarily in all circumstances. Hope this helps, Kersten External Email - Use Caution Hello FreeSurfer experts, I am using a mass-univariate pipeline to assess cortical thickness changes longitudinally at a regional level (based on the D-K atlas), and have been following this thread: MailScanner has detected a possible fraud attempt from "secure-web.cisco.com" claiming to behttps://http://secure-web.cisco.com/1OH1IdmTmp1zegRFjxpfr0wXoZPd0LxA71jtBdbSf-JZ4MmHH8vePfgkaL122xK74KDlCjFc9Z9tKAK9zLp6g5gtUm24hfYTjx2LYmvv1aQcVzVyOSAmzkTSjG-kTU-0crhhQXNCEzkDiEALdKRiz2VcWJYiM5P6cgLzPzFFGmSDGh1ylE0zM7bQWlLkS1KuyntMeJPIhn2gD84AdHs0kzZfwcJVlkTYy8urKcuT6ixmY2ZTKvN_on4mkMamJoWQaa-rrWIG-nEHodFqWCeWdtEmNgfivxNfA06SX0ROHzwcVQBKvgYbu3pbQg7Apbncz/http%3A%2F%2Fwww.mail-archive.com%2Ffreesurfer%40nmr.mgh.harvard.edu%2Fmsg76987.html<https://secure-web.cisco.com/1gfQ9eWAEqDZ3DGmI9NL7F2WPKbHBLsM60VyuP_LVR3dT1CV3DkQLnS7V3mw52P2LBaCekNfBwRZ37ft6dOBwXhzUo_wrbKJVG2XMB6GHfBDDPgLMXLkX7heqJ_KkmWwqJy9piolbuNnl5eaQ39pcYUHcoICiPTjHmCz39Kf6z2NQq9upBO5S0R7ruzTcfdlTWq2KiXcwnU5TGmYC3srVmnpf9O6iRWBD-KwL6sYWR9N7oVhfzBX4MGtQvWaZLqWHR1O2oClgbUhcdWbD_-CG15C0wAv3HIAwKDxQQ4Xz1z8IN_wUzZ3LBykDu0uR2LrPr465UModBjZSGhvR14zGWw/https%3A%2F%2Fwww.mail-archive.com%2Ffreesurfer%40nmr.mgh.harvard.edu%2Fmsg76987.html>. My pipeline is set up so that lme_mass_fit, lme_mass_F, and lme_mass_FDR are all run independently in a for-loop for each individual ROI, rather than altogether. Is this correct? As well, would using FDR2 be more advantageous than FDR? Best, Daniel Bondi The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Mass General Brigham Compliance HelpLine at https://secure-web.cisco.com/1v1L_BCMivW3bCQUU9Uu8NHjxSCKVstRZIv84UcEfiz1t-WVPGnanR808Kbr56z4NIuvXZ44eXkj_gRrR_UtpqKHneGWC-dwebiXsySLz7l5f9-UOVQpj8Nd8LUadIULY2A5WkuNYJfZZxLVu8kEoNAg7gTHDw39hWAAdkJNJ09zYTYeyxV1Q7GwclIAlfj2OU8d-J9VVFxdpdKqLfHHJar8PCPHYZ3YpbeAT91QikJ1GFhXM7_YeQPvipYigYCoiP49tAdzaFtIEXwY5R3Y8LPrqVPW9fc_KU9-JBCg5vLs0sSQ8lIGnfjR2_dop2trj/https%3A%2F%2Fwww.massgeneralbrigham.org%2Fcomplianceline . Please note that this e-mail is not secure (encrypted). If you do not wish to continue communication over unencrypted e-mail, please notify the sender of this message immediately. Continuing to send or respond to e-mail after receiving this message means you understand and accept this risk and wish to continue to communicate over unencrypted e-mail.
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