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Hi Freesurfer Mailing List,
I work on a large bipolar disorder imaging study that has been running for over
10 years. We previously acquired 2 sMRI time-points (pre 2013, n ~500, n ~250
at each time-point) on a single Philips 3T scanner and these images were
processed with Freesurfer version 5.3. We have just now acquired a third
imaging time-point that was completed on a different scanner (Siemans, n ~120)
using a different acquisition protocal. So I have three questions for the
mailing list, that I'm hoping will inform the design of our analysis protocol:
1. Are there specific considerations for processing structural MRIs that
have been acquired on different scanners and with different acquisition
protocols?
2. Reprocessing all time 1 and time 2 images with a newer version of
Freesurfer is a huge undertaking (for both processing time and personnel time
required to review and edit). However, is there a reason why a newer version of
Freesurfer should be used (e.g. publication considerations, more consistent
output) as opposed to processing time 3 with v5.3?
3. I know there are differences in the output across different versions of
Freesurfer. However, do different system set ups (e.g. linux, mac, as well as
operating systems) have an impact on the output, even if the same version of
Freesurfer is used?
Kind regards,
Bronwyn Overs
Research Assistant
Neuroscience Research Australia
Margarete Ainsworth Building
Barker Street Randwick Sydney NSW 2031 Australia
M 0411 308 769 T +61 2 9399 1725
[ http://neura.edu.au/ | neura.edu.au ]
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