On 4/18/2024 1:59 PM, Tejaswi D. Sudhakar wrote:
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Hello Freesurfer team,
I am interested in doing one glm analysis using both the thickness and
cortical surface area.
My question is two-fold:
First, is it possible to provide both the thickness and area files to
mris_preproc and mri_surf2surf commands or is it only possible to run
two separate glms (one for thickness and one for area)?
You must run two separate glms
Second, can we consider thickness and area as separate values or are
they both correlated? In other words, how correlated are the thickness
and area values?
They should be uncorrelated by construction (ie, the noise in the
thickness should be uncorrelated from that in the area), but they may
biologically correlated (don't know). When doing an area analysis, make
sure to turn on jacobian correction (on by default when you spec area to
mris_preproc) and correct for total head size. You will also need to do
the permutation corrections for multiple comparisons (for both thickness
and area but esp for area).
Thanks in advances,
Tejaswi
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