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Dear FreeSurfer Team,

I hope this email finds you well. I am reaching out to seek
clarification regarding the WMH-SynthSeg function in FreeSurfer.

I am interested in utilizing the WMH-SynthSeg function for the
computation of white matter hypointensity. However, I am uncertain
whether the resulting volume values undergo any form of normalization,
such as division by intracranial volume, etc. Currently, I lack
information on whether the obtained values are comparable across
different subjects. Could you please provide insights or guidance on
how the volume values are processed or standardized in WMH-SynthSeg?
Understanding this aspect is crucial for ensuring the comparability of
results across diverse study participants.

I appreciate your dedication to the development of FreeSurfer and look
forward to your valuable insights.

Best regards,
Liang Zhao
Nanjing Medical University

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