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Hello Freesurfer Developers,

I have never received an answer to my problem, maybe it was lost in the e-mails.

Kind regards,

Jeltje Spapens

From: "Spapens, Jeltje (NP)" <j.spap...@maastrichtuniversity.nl>
Date: Wednesday, 8 November 2023 at 13.55
To: "Freesurfer@nmr.mgh.harvard.edu" <Freesurfer@nmr.mgh.harvard.edu>
Subject: Problem with brainstem overlap after BBR

Hello Freesurfer Developers,

I have performed a boundary-based registration followed by a mri_vol2vol on a 
Neuromelanin sensitive MRI scan (partial FoV) with a T1 structural scan. I used 
this code:

Boundary-based registration in Freesurfer

Set the environment in the terminal.

bbregister --s MRS_203_recon_all --mov 
/Users/robspapens/Desktop/Thesis/Subjects/MRS_203/MRS_203_MT_tfl_stripped.mgz 
--reg MRS_203_NM2mp2rage.dat --T1 --init-fsl
mri_vol2vol --mov 
/Users/robspapens/Desktop/Thesis/Subjects/MRS_203/MRS_203_MT_tfl_stripped.mgz 
--targ /Users/robspapens/Desktop/Thesis/Subjects/MRS_203/MRS_203_upsamp.nii --o 
/Users/robspapens/Desktop/Thesis/Subjects/MRS_203/MRS_203_MT_tfl_regt1.nii.gz 
--reg MRS_203_NM2mp2rage.dat –cubic

I performed the analysis on two participants, but the brainstem does not 
overlap very nicely. I attached the screenshots of Freeview of the two 
participants with the T1 scan and the NM scan after the BBR. Our analysis 
focuses on the Substantia Nigra.
I also attached the full script that we use including the pre analysis.
Do you have a tip how to improve the BBR to reach better overlap.

Kind regards,

Jeltje Spapens



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