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Hi Emily,

thanks for your mail.

We have not tried running the LME tools with functional data before, but I 
guess it's worth a try.

I have to admit that I am also not very familiar with FreeSurfer's functional 
data file formats, so could you briefly describe how your data is stored (i.e. 
what file format, volume- or surface-based; and what does it reflect (1st level 
contrast estimates?)? Specifically, does it have the form of an mgh surface 
overlay file already?

I believe this would be the main issue, for the other things that you mention I 
currently do not foresee any major difficulties (but let's see).

Best,

Kersten


On Tue, 2023-10-24 at 00:24 +0000, Emily Iannazzi wrote:

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Hi there,

We are trying to conduct functional linear mixed model analyses on our 
longitudinal (2 timepoint) data but are having trouble applying the structural 
documentation to functional data, particularly with the functions 
fs_read_label.m, fs_read.surf.m, and fs_read_Y.m.

For instance, in the function [Y,mri] = fs_read_Y(‘lh.thickness.sm10.mgh’), 
which file should we be reading for functional data (instead of cortical 
thickness)?

Additionally, do any of the subsequent steps (building design matrix, model 
specification, parameter estimation) require further information to be adapted 
for functional data?

Any help would be greatly appreciated,
Emily

--
Emily Iannazzi (she/her)
Adult Clinical Psychology
University of Washington



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