External Email - Use Caution        

Sorry for the slow response.
1.1: the results are bound to be different (since they are different methods) 
but they should be very highly correlated. For the eTIV, please take a look at 
Figure 4 of 
https://secure-web.cisco.com/1pF9TRM2P6hqsAScfzof5e0z8hsMO6EE1AbG_H4lgFdrWqte-bj0VjPni0zSc7IT0uOt5s_TJCZyJUXa6c7aXwORIeJs4Nfd2yoRXpWhy28jcpSNq3Mni_609wcb-EnDlvXOZayNUVtfxUaRaAeN5WIL0YF0R9OADiKKY2_EowwQal4d8tgPnuxKp77F97Mh1MlLMl1NyzNLejHFjDgK1LFHf5N-sEbwg4aIVbTiA3iS2RajPg2p4Yqeq_rVFnNpAWjGhKG5NiNuJZgeYqI7xKg/https%3A%2F%2Fwww.pnas.org%2Fdoi%2F10.1073%2Fpnas.2216399120
1.2: Doug is totally right, about the zeroing of the ERC vs not. We are looking 
into this…

2. As of today, you’d have to run SynthSR (which is part of recon-all-clinical) 
and then process this fake 1mm T1 as if it was a new scan. More seamless 
integration of Synth tools and subregion segmentation is on the to-do list but 
not there yet.

Cheers,

/Eugenio



--
Juan Eugenio Iglesias
http://secure-web.cisco.com/1E89A-F8PBNW1olFMmiK25cpajXkwzWDj9tSwSoYI3-B2X4amrGKSyBhXtaRWt9_fpyX4-B4bDmWaAZHi7Ev8k7YyaKPj2N2O20yJMGaY7Jc4xdULLLWVdiOt9kww79asjNuLwKN8pUpbxfHTfTiRLMaccWDFiWDtrRcmOT6kpplETtPJvirozkQIXu1hHOCSNZGhR6uaIbSdb2C_jn72mreq3lHOkFS0idXXgYt8-oVbbHYWcoayjEXr4_E4dj3C/http%3A%2F%2Fwww.jeiglesias.com

From: freesurfer-boun...@nmr.mgh.harvard.edu 
<freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of Douglas N. Greve 
<dgr...@mgh.harvard.edu>
Date: Thursday, July 20, 2023 at 4:30 PM
To: freesurfer@nmr.mgh.harvard.edu <freesurfer@nmr.mgh.harvard.edu>, Gopinath, 
Karthik <kgopin...@mgh.harvard.edu>
Subject: Re: [Freesurfer] Questions for the estimated brain volume based on new 
version of FreeSurfer

        External Email - Use Caution
First of all, you are not going to get the same answer from these different 
programs. For ento, recon-all will zero the thickness in some areas around 
ento, and clinical is probably not doing that. Still a factor of 4 seems pretty 
large. Maybe Karthik has looked at it.
On 7/6/2023 11:21 PM, Yoonho Hwang wrote:

        External Email - Use Caution
Dear FS developers,

Hi,

I am very happy that we can use new features of FreeSurfer (e.g., 
recon-all-clinical.sh, SynthSeg, SynthSR, etc.)
While using a variety of functions from FreeSurfer (v7.3.2 and v7.4.1), we 
would like to hear the answers to the following questions.

1-1. Compared to the recon-all stream, using SynthSeg seems to overestimate the 
volume in many subregions of the brain including eTIV? Can you explain why this 
happens?
1-2. The estimated volume of the entorhinal cortex is different between 
recon-all/SynthSeg and recon-all-clinical.sh. There is a 3-4 times difference. 
Can you tell me why the result is?

2. Can the functions (segment_subregions, segmentThalamicNuclei.sh, 
segmentBA.sh, segmentHA.sh, etc.) used in recon-all be used in 
recon-all-clinical.sh?

Please let me know if there is anything you don't understand.
Looking forward to your feedback.
Thank you very much.

Best,
Yoonho

--
Hwang, Yoonho

Research professor
Institute of Human Genomic Study,
College of Medicine, Korea University

#123, Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, 15355, Republic of Korea.

Email: ken.lmsta...@gmail.com<mailto:ken.lmsta...@gmail.com>



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