External Email - Use Caution        

That EPI factor is wrong (if it is a single shot EPI sequence the EPI factor 
should equal the number of phase encoding steps).  That said, it should not 
matter for eddy/topup unless you want correctly scaled field coefficients 
(these algorithms internally don’t care about this scaling and estimate the 
distortions directly from the data).  Note that if you do not distortion 
correct your images, they will not accurately align with your structural data.

Matt.

From: <[email protected]> on behalf of "Blujus, Jenna" 
<[email protected]>
Reply-To: Freesurfer support list <[email protected]>
Date: Sunday, June 25, 2023 at 8:29 AM
To: "[email protected]" <[email protected]>
Subject: [Freesurfer] EPI Factor generated by dmri_bids_config



        External Email - Use Caution
Hi all,

I am using TRACULA (v7.3.2) to examine longitudinal changes in WM integrity by 
diagnostic groups.

For preprocessing, I did not use topup because my data have a single 
acquisition (i.e., I do not have two acquisitions with opposing polarities of 
the phase-encode blips).  But I did utilize the Eddy command for eddy current 
and motion correction. To do so TRACULA requires information regarding the epi 
factor, echo spacing, and phase encoding direction. My data are in BIDS format 
and so I used the dmri_bids_config script to extract these factors. While the 
echo spacing and PE direction match the information in my json files, I am 
finding that I am getting a large EPI factor (e.g., 115001.0273).

I looked at the acqp.txt file generated for use with Eddy and the correct 
values are stored in the file for each subject (PE direction [0 1 0] and total 
readout time) so I believe the command was executed properly despite the large 
magnitude EPI factor.

My questions are:
1. How is the EPI factor used in preprocessing by TRACULA?
2. Will the magnitude difference in the EPI factor affect the preprocessing of 
the DWI data if topup is turned off and only eddy is used?

Thanks,
Jenna

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