External Email - Use Caution        

Uuummm I don’t think this would work, as a lot of our intermediate files (eg 
norm.mgz) are not comparable to their counterparts in the standard recon-all 
stream. Sorry!

--
Juan Eugenio Iglesias
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From: freesurfer-boun...@nmr.mgh.harvard.edu 
<freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of Douglas N. Greve 
<dgr...@mgh.harvard.edu>
Date: Tuesday, June 20, 2023 at 9:32 AM
To: freesurfer@nmr.mgh.harvard.edu <freesurfer@nmr.mgh.harvard.edu>, Iglesias 
Gonzalez, Eugenio <e.igles...@ucl.ac.uk>, Gopinath, Karthik 
<kgopin...@mgh.harvard.edu>
Subject: Re: [Freesurfer] recon-all-clinical

        External Email - Use Caution

On 5/26/2023 5:39 PM, Andrew Dedinas Geoly wrote:

        External Email - Use Caution
Hello Freesurfer experts!

I am conducting a longitudinal GMV and CT analysis of mTBI participants who 
received an experimental single-dose pharmacological treatment. We collected GE 
Bravo (0.9mm isotropic) T1w data pre, immediately after (~ 4 days after 
intervention) and 1-month following the intervention.

I have been working with the recon-all longitudinal pipeline stream  (7.1.1) 
but have noticed pretty significant errors in terms of skull stripping and 
segmentation (participants are veterans with somewhat random lesion / atrophy 
patterns).

I have tested your new recon-all-clinical program (7.4.0) on some of my worst 
cases and it is performing remarkably well. I am doing some more digging into 
the various synth segmentation packages available in FS newest versions and was 
wondering what the best course of action would be for integrating 
recon-all-clinical or synthseg into a longitudinal workflow.

1.Could I use the recon-all-clinical outputs as the "cross" for later base and 
long template construction?
I don't know. Hopefully Eugenio/Karthik will weigh in

2. SynthSeg and SCLimbic seem to have very good test-retest reliability-- would 
it be feasible to use the independent segmentation extractions from those and 
bypass the longitudinal stream entirely (not saying I would want to but I am 
curious)?
sclimbic generates segs that are not in the long stream, so there is no long 
option. My experience with synthseg is that it is inferior to the long stream 
on long data


Any and all help here would be greatly appreciated, and I thank you very much 
for your time.


Warmest regards,
Andrew



---



Andrew D. Geoly, MS



Research Data Analyst 1



Brain Stimulation Lab



Department of Psychiatry and Behavioral Sciences



Stanford University School of Medicine







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