Hi Chris,

Since there is only one timepoint, the base recon-all command will look like 
this:
recon-all -base <templateid> -tp <tp1id> -all

<tp1id> is the subjectID for the one timepoint you have. Not sure how you named 
<templateid>. It should be an unique name in your SUBJECTS_DIR.

Hope this helps.

Best,

Yujing

From: freesurfer-boun...@nmr.mgh.harvard.edu 
<freesurfer-boun...@nmr.mgh.harvard.edu> On Behalf Of Hemond, Christopher
Sent: Wednesday, March 29, 2023 2:02 PM
To: freesurfer@nmr.mgh.harvard.edu
Subject: [Freesurfer] Longitudinal processing of single time point data


        External Email - Use Caution
Dear Freesurfer experts,
I am processing longitudinal data from subjects participating in a pre-post 
analysis; a few subjects do not have follow-up data.  I'd like to still include 
these subjects and plan on using mixed effects analysis methods given the 
unbalanced data.
I am following the wiki tutorials in this regard (specifically MailScanner has 
detected a possible fraud attempt from "secure-web.cisco.com" claiming to be 
https://surfer.nmr.mgh.harvard.edu/fswiki/LongitudinalProcessing<https://secure-web.cisco.com/1YHlXw74PCpQ3T6qawqkxxMCM_VcHyTlbf-HZnuBTtb68uuIXxLXB_5t7zOtAtZnDWU2iAiVhOM-Qg0sWs_-iJEwQQoVWur6NJapgVdeQzQQYUlhk6O3h88ue-fC6_pDJ3gmlRd_v_dqsjQBWFRvzInbw16_kEsTuzvTNEaNYY_ORuffGXYyh4Pwo1SPOPiSQ-JYykIcQWn2q2BTgBMVOJAz7u2rykJiG2aoHFLwikwgBrHomMrmV1bWH4czxaSXDOQTEQvpMDSZi7ayG6leyH_G-m2F69lFSKD3khpnLRshifw5FCcAXI-IhaSJrKfRFI2KbsbaRTQ4qL69oh7q4Zw/https%3A%2F%2Fsurfer.nmr.mgh.harvard.edu%2Ffswiki%2FLongitudinalProcessing>),
 which suggests that subjects having a single time point should be processed in 
the longitudinal pipeline to reduce bias (from Bernal-Rusiel 2013).  From the 
webpage:
"Single time-point subjects: Because of drop-outs it can happen that some 
individuals were scanned only at a single time point. Instead of removing this 
valuable information, it is possible (e.g. in the linear mixed effects models 
LME) to include this data. For that it, however, becomes necessary to run the 
single time points through the longitudinal stream, to ensure that also those 
images undergo the same processing steps. This can be done by simply passing a 
single time point in the base creation step"

On a single-timepoint subject I ran:  "recon-all -base <subject_base> -tp 
<baseline_timepoint> -all

However I get the following error:
ERROR: It appears that the -base templateID that you passed:
       -base <subject_base>
       is an existing regular (cross sectional) run!
       Please make sure you pass a new name (not one of
       the time points) for the template with -base.

I've searched the archive but didn't find anything with this.  Maybe I am doing 
something obviously wrong!  Any help you could provide would be greatly 
appreciated.
I'm running freesurfer-darwin-macOS-7.3.2-20220804-6354275.

Many thanks,
Chris



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