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Good luck. It requires a 7T to separate the compacta and reticulata.
Localizing the the substantia nigra  is impossible with standard MPRAGES
but can be done if you modify the sequence or use a adequate T2 .   There
are papers that discuss how to localize it you do not need FreeSurfer.

On Mon, Mar 6, 2023 at 4:57 PM Christian Owen <cowen...@gmail.com> wrote:

>         External Email - Use Caution
>
> Hi,
>
> The latest post I could find about substantia nigra segmentation in
> FreeSurfer is from May 2020
> <https://secure-web.cisco.com/1kbKgUj7tgWerg-kNskO0E4pbYddAh99-3abcyl688pSr522HGfljzK8Vg4SNMuYr1Re0HWn70-luj0Zzcnr82x_lSUWwV4aI18Nm1oXzKf2dbtRMimEn_Y-IUUPqisF8FJzamdL_zEhIJ7TjwB0DFoVBD9qQROzryqS6T7F-vngpBezA3DNc86hQBa5kidKRPzit-26Vi2sMP5KuRqZNwS7dKQ7oBvVh1AQ0gBqIb3ErPoJx3CYBiwW9aiEkSmbR_LDBqWH_A7-dgzmJvFbbchq2K6PaLGbm0zf1L5CyK4HJ4BFVg00hqKbyH_QUKGHjzBubOr-kXKehbegvMQt9AA/https%3A%2F%2Fwww.mail-archive.com%2Ffreesurfer%40nmr.mgh.harvard.edu%2Fmsg66192.html>.
> As of that post, it was not possible. Is it still not possible? If that's
> the case:
>
> - is substantia nigra segmentation on the roadmap?
> - is there anything a software engineer could do to help make it happen? I
> cannot promise any resources atm, but there's a chance we could help out
> (if it turns out to be enough of a priority).
>
> Best,
> Christian
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