External Email - Use Caution Dear FreeSurfer experts,
I dealing with some issues regarding skull stripping in FreeSurfer (v7.1.1). It seems like the conventional approaches (e.g., adjusting -wsthresh) doesn’t seem to help. As well, applying these preprocessing steps to the raw T1w BEFORE processing in FreeSurfer doesn’t seem to help either. I have tried: intensity truncation, N4 bias field correction, data normalization (with different combinations). Considering that we’re analyzing data from a large dataset (>500 scans * multiple timepoints), manual editing may not feasible. Therefore, to address poor skull stripping, I was wondering if it is possible to use a brain mask created outside FreeSurfer for the same subject to help with skull stripping. I saw in previous emails in the Archive that the steps below could work. Can someone confirm if this is still true and would work for v7.1.1? 1. run recon-all (as one normally would) 2. apply mri_mask to mask the T1.mgz with external brain mask volume (in native space) 3. name the output “brainmask.mgz” and move it to "subjid/mri/“ 3. re-run recon-all starting from -autorecon2 -autorecon3 Thanks for your help! Nárlon Cássio Nárlon Cássio Boa Sorte Silva PhD (He, Him, His) CIHR and MSHR BC/PARF Postdoctoral Research Fellow Aging, Mobility, and Cognitive Health Lab Djavad Mowafaghian Centre for Brain Health Department of Physical Therapy, Faculty of Medicine University of British Columbia Vancouver, Canada Twitter: @BoaNarlon
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