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Dear Dr Bruce,
Thank you very much for your guidance.
I ran recon-all on a subject "test" using Freesurfer V6.0 and the following
command line is reported in the "recon-all.log":

/usr/local/freesurfer/6.0/bin/recon-all -all -qcache -i T1.nii.gz -flair
FLAIR.nii.gz -s test

When I search for normalization of flair, I only find how Freesurfer
normalized T1.
I searched for "nonmax_suppress" and it is not in the log file. I am just
wondering what I am doing wrong. Thanks again for any highlights about the
correct method to normalize FLAIR

Sincerely,



Hi JamesB

there is T2/FLAIR normalization in recon-all if you process it through
there. You can look for "nonmax_suppress" if you want to find the command
line

cheers
Bruce

On Fri, Sep 23, 2022 at 2:06 PM James Brown <jb1979...@gmail.com> wrote:

> Dear Freesurfer experts,
> We appreciate any advice or guidance from your community of professionals
> and experts in the field about the issue below.
>
> Thank you for your kindness.
>
> Dear Freesurfer experts,
> In order to normalize white matter intensity of T1 images and correct for
> bias field. We do the following steps:
> mri_convert T1.nii.gz T1.mgz
> mri_nu_correct.mni --i T1.mgz --o T1_N3.mgz --n 2
> mri_normalize -g 1 T1_N3.mgzT1_norm.mgz
> mri_convert T1_norm.mgz T1_norm.nii.gz
>
> We would like to apply bias field correction on FLAIR images then
> normalize white matter intensity.
> We tried N4biasfieldcorrection from ANTS but it didn't work as expected.
> Reviewing documents about N4biasfieldcorrection we realize that the
> algorithm has been developed to correct bias field correction in T1 not
> clear if it works on FLAIR images.
>
> Are the steps above valid for normalizing FLAIR images or can it only be
> applied on T1 images? I would like to send a "recon-all.log" file that
> includes the processing steps of FLAIR. Is there any link I can use to
> upload the file. It gets rejected every time I send it due to size
> limitations.
>
> We appreciate any feedback about the proper way to correct FLAIR images
> for bias fields and normalize white matter intensity in FLAIR images.
>
> Thank you
> JamesB
>
> On Wed, Sep 21, 2022 at 10:18 AM James Brown <jb1979...@gmail.com> wrote:
>
>> Dear Freesurfer experts,
>> In order to normalize white matter intensity of T1 images and correct for
>> bias field. We do the following steps:
>> mri_convert T1.nii.gz T1.mgz
>> mri_nu_correct.mni --i T1.mgz --o T1_N3.mgz --n 2
>> mri_normalize -g 1 T1_N3.mgzT1_norm.mgz
>> mri_convert T1_norm.mgz T1_norm.nii.gz
>>
>> We would like to apply bias field correction on FLAIR images then
>> normalize white matter intensity.
>> We tried N4biasfieldcorrection from ANTS but it didn't work as expected.
>> Reviewing documents about N4biasfieldcorrection we realize that the
>> algorithm has been developed to correct bias field correction in T1 not
>> clear if it works on FLAIR images.
>>
>> Are the steps above valid for normalizing FLAIR images or can it only be
>> applied on T1 images? I would like to send a "recon-all.log" file that
>> includes the processing steps of FLAIR. Is there any link I can use to
>> upload the file. It gets rejected every time I send it due to size
>> limitations.
>>
>> We appreciate any feedback about the proper way to correct FLAIR images
>> for bias fields and normalize white matter intensity in FLAIR images.
>>
>> Thank you
>> JamesB
>>
>
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