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comparing the results of longitudinal vs. crosssectional preprocessing for single time point participants I have noticed that there are some quite substantial differences (>5% for some sub cortical regions). I wonder whether this is normal, or whether I should suspect that I am using some wrong setting. the differences are there both when using freesurfer 5.3 and freesurfer 7.1. I have always used the flag: -nuintensitycor-3T (our scanner is a 3 Tesla one) I would say that I more often have smaller volumes in the longi preprocessing (80% of the cases), but I haven't checked this systematically. This are the first 5 regions from the aseg.stats file: FS5 CROSS # ColHeaders Index SegId NVoxels Volume_mm3 StructName normMean normStdDev normMin normMax normRange 1 4 4772 4772.4 Left-Lateral-Ventricle 45.4073 12.8146 24.0000 92.0000 68.0000 2 5 133 132.6 Left-Inf-Lat-Vent 51.9800 10.2799 28.0000 77.0000 49.0000 3 7 13488 13488.1 Left-Cerebellum-White-Matter 91.1006 5.2419 37.0000 106.0000 69.0000 4 8 57562 57561.8 Left-Cerebellum-Cortex 72.0094 8.7033 24.0000 96.0000 72.0000 5 10 8428 8428.3 Left-Thalamus-Proper 94.7674 7.1110 52.0000 111.0000 59.0000 FS5 LONGI # ColHeaders Index SegId NVoxels Volume_mm3 StructName normMean normStdDev normMin normMax normRange 1 4 4542 4541.9 Left-Lateral-Ventricle 42.8623 13.5582 22.0000 94.0000 72.0000 2 5 131 130.5 Left-Inf-Lat-Vent 50.6667 11.1812 23.0000 81.0000 58.0000 3 7 13576 13576.1 Left-Cerebellum-White-Matter 86.1990 4.5161 40.0000 100.0000 60.0000 4 8 57615 57614.7 Left-Cerebellum-Cortex 68.7623 8.6206 17.0000 92.0000 75.0000 5 10 8658 8658.2 Left-Thalamus-Proper 91.2531 6.7374 52.0000 107.0000 55.0000 FS7 CROSS # ColHeaders Index SegId NVoxels Volume_mm3 StructName normMean normStdDev normMin normMax normRange 1 4 4871 5297.0 Left-Lateral-Ventricle 43.9799 11.8868 24.0000 91.0000 67.0000 2 5 145 202.9 Left-Inf-Lat-Vent 53.7310 10.0009 28.0000 79.0000 51.0000 3 7 14703 15351.7 Left-Cerebellum-White-Matter 86.7391 5.5097 35.0000 100.0000 65.0000 4 8 57694 57174.0 Left-Cerebellum-Cortex 68.6875 9.0320 29.0000 95.0000 66.0000 5 10 8674 8354.1 Left-Thalamus 89.9416 8.1369 40.0000 107.0000 67.0000 FS7 longi # ColHeaders Index SegId NVoxels Volume_mm3 StructName normMean normStdDev normMin normMax normRange 1 4 4898 5154.3 Left-Lateral-Ventricle 41.0488 12.0309 22.0000 79.0000 57.0000 2 5 165 214.4 Left-Inf-Lat-Vent 52.3939 11.2687 27.0000 84.0000 57.0000 3 7 14655 15364.2 Left-Cerebellum-White-Matter 83.1088 4.9509 39.0000 98.0000 59.0000 4 8 58759 58163.3 Left-Cerebellum-Cortex 65.8093 8.7269 25.0000 90.0000 65.0000 5 10 8757 8542.9 Left-Thalamus 85.7984 6.8821 47.0000 102.0000 55.0000 thanks for any hint, and of course please let me know in case I should provide more informations! fabio bernardoni Dr. Fabio Bernardoni wiss. Mitarbeiter Division of Psychological & Social Medicine and Developmental Neurosciences http://secure-web.cisco.com/1agu0o6sn74nWpsbJ7svbMRxn_ehBHd-f92Wr82FruYql6-5gzPLns-0KWG220DmGx-h5cqZZOWM1rIy0oPKilcVolnjxjTkTA4znrqnXz3a3mW3vf3fBrSmnMtizh16SThuPcwb0hTS3pL3O26VDQ2455LzCnYgmPZCCms5DuDfaof8UIBvWEpY7I4doWst_ks5hNagDpbfec7nPxSo2actD3cuMPxfOsJ_9nGaQjAjcfHlwxVyydCZwc04OKLZMvQRYHjVHciPPwbK571HOQpAcjSvzvuOf3EOTgOR1mttvP81BSgR5zB-w5jyn8KKM/http%3A%2F%2Fwww.transdenlab.de%2F; http://secure-web.cisco.com/1-VhMi9tn4-tr0pk3F2qG7WlFkii1dQTQ9ft5HX2sq051wF5qnNzX1jjIX5N47FReicMML-3RaZBih1iiN2qV88YojRcS3g18tZoaAcRDFTMFkvGNonKMLARO95hgjet3Y7KHTaBW_I5qUIV4Bou94U9jBjhiVSSLvDcbg8v407sonnu7e4ZDPQ053msRkRlsVl7S_HHOUkt1UIaIDVZ2KUmWX10bFYUFDM6OywmbuOXwMDenrFzlAJR4J9QEGhDksgSxKOFBORinuaW12ieB9fDFZFwQgQgJHjd8hDnLSVdBLLCDFJbORgQ6RZmlu20BxCD5A2Ek85Sa7ZPPj7mnwA/http%3A%2F%2Fwww.uniklinikum-dresden.de%2Fpsm +49 (0351) 458-5245 Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden Anstalt des öffentlichen Rechts des Freistaates Sachsen Fetscherstraße 74, 01307 Dresden http://secure-web.cisco.com/1AJszz-L1qPC476T5Uq6yduAdSp7WLJHps2MDHMdb5shfw1rjpYnmv5nc0piFTZBTt3s6ga-ZZVFvwFAy0sIXAX2yYZFZ3yfqK_6k7d9It4G1Mh-unIRX1bYxSlExBZ4cffssaSZO2MPapxNbom2gybY9rwTZKdk6eajFxfmi0i66CT0VnsC4ziCdEwGBd85CwO9CzHWTTjwTi74Fc6Hz4oy2KAh9PHD0LUROOSiIvHHmx0DmP-wZp5rdwK6LFhswQnz0q9Frf7KB1M3HIJYuv412A15_K_sGkJ9hW2Lh8QWvG_trUYtQayZ6D9OyvaBhHQoLcbI5P_VxuL3C_cVEeQ/http%3A%2F%2Fwww.uniklinikum-dresden.de Vorstand: Prof. Dr. med. D. M. Albrecht (Sprecher), Katrin Erk Vorsitzender des Aufsichtsrates: Prof. Dr. G. Brunner USt.-IDNr.: DE 140 135 217, St.-Nr.: 203 145 03113 http://secure-web.cisco.com/1AJszz-L1qPC476T5Uq6yduAdSp7WLJHps2MDHMdb5shfw1rjpYnmv5nc0piFTZBTt3s6ga-ZZVFvwFAy0sIXAX2yYZFZ3yfqK_6k7d9It4G1Mh-unIRX1bYxSlExBZ4cffssaSZO2MPapxNbom2gybY9rwTZKdk6eajFxfmi0i66CT0VnsC4ziCdEwGBd85CwO9CzHWTTjwTi74Fc6Hz4oy2KAh9PHD0LUROOSiIvHHmx0DmP-wZp5rdwK6LFhswQnz0q9Frf7KB1M3HIJYuv412A15_K_sGkJ9hW2Lh8QWvG_trUYtQayZ6D9OyvaBhHQoLcbI5P_VxuL3C_cVEeQ/http%3A%2F%2Fwww.uniklinikum-dresden.de Vorstand: Prof. Dr. med. D. M. Albrecht (Sprecher), Wilfried E. B. Winzer Vorsitzender des Aufsichtsrates: Prof. Dr. G. Brunner USt.-IDNr.: DE 140 135 217, St.-Nr.: 203 145 03113
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