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Dear experts,
I would like to run mri_glmfit in a group analysis. However, I met the 
following error when I added the medicationload as variable in my fsgd file.
Since I have 305 subjects and only 75 of these have medication load, it seems 
to this variable includes too many zero. Just I guess.
The error:
ERROR: matrix is ill-conditioned or badly scaled, condno = 1e+08\
\
\
--------------------------------\
-------- ERROR: READ THIS -----------------\
--vvvvvvvvvvvvvvvvvvvvvvvvvvvvvv-----\
Possible problem with experimental design:\
Check for duplicate entries and/or lack of range of\
continuous variables within a class.\
If you seek help with this problem, make sure to send:\
  1. Your command line:\
    mri_glmfit --y lh.volume.BDHC3Study.10.mgh --fsgd FSGD/BDHC3Study.fsgd --C 
Contrasts/HC3-BD3.mtx --C Contrasts/BD3-HC3.mtx --surf fsaverage lh --cortex 
--glmdir lh.volume.BDHC3Study.10.glmdir \
  2. The terminal output of this program (ie, everything it prints to the 
screen)\
  3. The FSGD file (FSGD/BDHC3Study.fsgd)\
  4. The design matrix lh.volume.BDHC3Study.10.glmdir/Xg.dat\
Attempting to diagnose further \
SumSq: Min=6.368664 (col 8), Max=16.261612 (col 7)\
... could not determine the cause of the problem\
--^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^----\
}

I attached my terminal output, fsgd file, and design matrix

Thanks

Yuan

Attachment: BDHC3Study.fsgd
Description: BDHC3Study.fsgd

{\rtf1\ansi\ansicpg936\cocoartf2578
\cocoatextscaling0\cocoaplatform0{\fonttbl\f0\fnil\fcharset0 AndaleMono;}
{\colortbl;\red255\green255\blue255;\red228\green225\blue224;\red0\green0\blue0;}
{\*\expandedcolortbl;;\cspthree\c91229\c90457\c90129;\csgray\c0\c90000;}
\paperw11900\paperh16840\margl1440\margr1440\vieww11520\viewh8400\viewkind0
\pard\tx560\tx1120\tx1680\tx2240\tx2800\tx3360\tx3920\tx4480\tx5040\tx5600\tx6160\tx6720\pardirnatural\partightenfactor0

\f0\fs24 \cf2 \cb3 \CocoaLigature0 yuan@macbook-pro-4 struct % tcsh 
runGLMs_Step2.sh BDHC3Study\
gdfRead(): reading FSGD/BDHC3Study.fsgd\
INFO: demeaning continuous variables\
Continuous Variable Means (all subjects)\
0 age 24.1115 7.32707\
1 edu 15.4131 3.21673\
2 medicationload 0.75082 1.46775\
3 tiv 1.52969e+06 162728\
Class Size and Means of each Continuous Variable\
1 BD 150  22.6667  13.8733   1.5267 1534142.9100 \
2 HC 155  25.5097  16.9032   0.0000 1525383.7726 \
INFO: gd2mtx_method is dods\
Reading source surface 
/Volumes/structrual/subject_struct/struct/fsaverage/surf/lh.white\
Number of vertices 163842\
Number of faces    327680\
Total area         65416.984375\
AvgVtxArea       0.399269\
AvgVtxDist       0.721953\
StdVtxDist       0.195470\
\
7.2.0\
cwd /Volumes/structrual/subject_struct/struct\
cmdline mri_glmfit --y lh.volume.BDHC3Study.10.mgh --fsgd FSGD/BDHC3Study.fsgd 
--C Contrasts/HC3-BD3.mtx --C Contrasts/BD3-HC3.mtx --surf fsaverage lh 
--cortex --glmdir lh.volume.BDHC3Study.10.glmdir \
sysname  Darwin\
hostname 192.168.1.2\
machine  x86_64\
user     caoyuan\
FixVertexAreaFlag = 1\
UseMaskWithSmoothing     1\
OneSampleGroupMean 0\
y    /Volumes/structrual/subject_struct/struct/lh.volume.BDHC3Study.10.mgh\
logyflag 0\
usedti  0\
FSGD FSGD/BDHC3Study.fsgd\
labelmask  
/Volumes/structrual/subject_struct/struct/fsaverage/label/lh.cortex.label\
maskinv 0\
glmdir lh.volume.BDHC3Study.10.glmdir\
IllCondOK 0\
ReScaleX 1\
DoFFx 0\
Creating output directory lh.volume.BDHC3Study.10.glmdir\
Loading y from 
/Volumes/structrual/subject_struct/struct/lh.volume.BDHC3Study.10.mgh\
   ... done reading.\
INFO: gd2mtx_method is dods\
Saving design matrix to lh.volume.BDHC3Study.10.glmdir/Xg.dat\
Computing normalized matrix\
Normalized matrix condition is 1e+08\
Design matrix ------------------\
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-0.24993   0.00000;\
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 0.15378   0.00000;\
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 1.65662   0.00000;\
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 1.00000   0.00000   0.25775   0.00000  -0.12843   0.00000   0.16977   0.00000  
 0.83194   0.00000;\
 1.00000   0.00000  -0.83410   0.00000  -1.37192   0.00000   0.85108   0.00000  
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 2.27539   0.00000;\
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 0.27499   0.00000;\
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 1.26653   0.00000;\
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 0.16217   0.00000;\
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 0.23234   0.00000;\
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 2.38876   0.00000;\
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 0.13799   0.00000;\
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 1.48800   0.00000;\
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 1.00000   0.00000  -0.69762   0.00000   0.18245   0.00000  -0.51154   0.00000  
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 1.00000   0.00000   3.12383   0.00000  -1.06105   0.00000   2.21371   0.00000  
 1.91621   0.00000;\
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 1.29735   0.00000;\
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 2.15805   0.00000;\
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 0.49463   0.00000;\
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 0.00510   0.00000;\
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 1.33011   0.00000;\
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 0.42514   0.00000;\
 1.00000   0.00000  -0.83410   0.00000  -0.12843   0.00000  -0.51154   0.00000  
 0.51325   0.00000;\
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 0.12466   0.00000;\
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 0.26920   0.00000;\
 1.00000   0.00000  -0.83410   0.00000  -1.37192   0.00000   1.53240   0.00000  
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 1.00000   0.00000  -0.28817   0.00000  -0.12843   0.00000   2.89502   0.00000  
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 1.00000   0.00000  -0.83410   0.00000  -1.06105   0.00000  -0.51154   0.00000  
 1.38419   0.00000;\
 1.00000   0.00000  -1.10706   0.00000  -1.37192   0.00000   0.85108   0.00000  
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 1.00000   0.00000   0.66719   0.00000   0.18245   0.00000  -0.51154   0.00000  
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 1.00000   0.00000   0.53071   0.00000   0.18245   0.00000   0.85108   0.00000  
 0.06984   0.00000;\
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 1.00000   0.00000  -0.42465   0.00000  -0.43930   0.00000   1.53240   0.00000  
 1.17289   0.00000;\
 1.00000   0.00000   1.75903   0.00000  -0.12843   0.00000  -0.51154   0.00000  
-1.06727   0.00000;\
 1.00000   0.00000  -1.10706   0.00000  -1.37192   0.00000   0.85108   0.00000  
 0.31477   0.00000;\
 1.00000   0.00000  -0.56114   0.00000  -1.06105   0.00000   0.16977   0.00000  
 0.15572   0.00000;\
 1.00000   0.00000  -0.83410   0.00000  -1.06105   0.00000  -0.51154   0.00000  
-1.12795   0.00000;\
 1.00000   0.00000  -0.15169   0.00000  -0.12843   0.00000   1.53240   0.00000  
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 1.00000   0.00000   0.12127   0.00000  -1.06105   0.00000   2.21371   0.00000  
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 1.00000   0.00000  -0.01521   0.00000   0.18245   0.00000  -0.51154   0.00000  
 0.38365   0.00000;\
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-1.59257   0.00000;\
 1.00000   0.00000  -0.42465   0.00000  -0.12843   0.00000   0.16977   0.00000  
 0.28286   0.00000;\
 1.00000   0.00000   2.03199   0.00000   0.18245   0.00000   1.53240   0.00000  
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 1.00000   0.00000  -0.83410   0.00000  -1.06105   0.00000   2.21371   0.00000  
 1.83885   0.00000;\
 1.00000   0.00000  -0.83410   0.00000  -1.06105   0.00000   2.89502   0.00000  
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 1.00000   0.00000   1.07663   0.00000   1.11507   0.00000   0.85108   0.00000  
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 1.00000   0.00000   1.34959   0.00000   0.18245   0.00000  -0.51154   0.00000  
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 1.00000   0.00000  -0.83410   0.00000  -0.75018   0.00000  -0.51154   0.00000  
 1.54214   0.00000;\
 1.00000   0.00000   0.12127   0.00000  -0.12843   0.00000   2.21371   0.00000  
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 1.00000   0.00000  -0.83410   0.00000  -1.06105   0.00000  -0.51154   0.00000  
 1.79311   0.00000;\
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 1.74033   0.00000;\
 1.00000   0.00000  -0.83410   0.00000  -1.06105   0.00000   0.85108   0.00000  
 0.36628   0.00000;\
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 3.04103   0.00000;\
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 1.48859   0.00000;\
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 0.61445   0.00000;\
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 2.22196   0.00000;\
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 0.16742   0.00000;\
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-1.74728   0.00000;\
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 0.57873   0.00000;\
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 1.09474   0.00000;\
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 0.00000   1.00000   0.00000   0.39423   0.00000   1.42595   0.00000  -0.51154  
 0.00000  -0.24814;\
 0.00000   1.00000   0.00000   0.39423   0.00000   1.42595   0.00000  -0.51154  
 0.00000   1.27980;\
 0.00000   1.00000   0.00000   0.39423   0.00000   0.80420   0.00000  -0.51154  
 0.00000  -0.27802;\
 0.00000   1.00000   0.00000   0.53071   0.00000   1.42595   0.00000  -0.51154  
 0.00000  -0.37874;\
 0.00000   1.00000   0.00000   0.39423   0.00000   1.42595   0.00000  -0.51154  
 0.00000   0.60943;\
 0.00000   1.00000   0.00000   0.12127   0.00000   0.18245   0.00000  -0.51154  
 0.00000   0.21685;\
 0.00000   1.00000   0.00000   0.12127   0.00000   0.49332   0.00000  -0.51154  
 0.00000  -0.15463;\
 0.00000   1.00000   0.00000   0.39423   0.00000   0.49332   0.00000  -0.51154  
 0.00000  -0.07122;\
 0.00000   1.00000   0.00000   0.25775   0.00000   1.42595   0.00000  -0.51154  
 0.00000   0.41914;\
 0.00000   1.00000   0.00000   0.39423   0.00000   1.11507   0.00000  -0.51154  
 0.00000  -0.02571;\
 0.00000   1.00000   0.00000  -0.15169   0.00000   0.80420   0.00000  -0.51154  
 0.00000  -1.48142;\
 0.00000   1.00000   0.00000  -0.15169   0.00000   0.49332   0.00000  -0.51154  
 0.00000  -0.71758;\
 0.00000   1.00000   0.00000   0.12127   0.00000   0.18245   0.00000  -0.51154  
 0.00000   0.72284;\
 0.00000   1.00000   0.00000   0.80367   0.00000   0.80420   0.00000  -0.51154  
 0.00000   0.31165;\
--------------------------------\
ERROR: matrix is ill-conditioned or badly scaled, condno = 1e+08\
\
\
--------------------------------\
-------- ERROR: READ THIS -----------------\
--vvvvvvvvvvvvvvvvvvvvvvvvvvvvvv-----\
Possible problem with experimental design:\
Check for duplicate entries and/or lack of range of\
continuous variables within a class.\
If you seek help with this problem, make sure to send:\
  1. Your command line:\
    mri_glmfit --y lh.volume.BDHC3Study.10.mgh --fsgd FSGD/BDHC3Study.fsgd --C 
Contrasts/HC3-BD3.mtx --C Contrasts/BD3-HC3.mtx --surf fsaverage lh --cortex 
--glmdir lh.volume.BDHC3Study.10.glmdir \
  2. The terminal output of this program (ie, everything it prints to the 
screen)\
  3. The FSGD file (FSGD/BDHC3Study.fsgd)\
  4. The design matrix lh.volume.BDHC3Study.10.glmdir/Xg.dat\
Attempting to diagnose further \
SumSq: Min=6.368664 (col 8), Max=16.261612 (col 7)\
 ... could not determine the cause of the problem\
--^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^----\
}

Attachment: mri_glmfit.log
Description: mri_glmfit.log

Attachment: Xg.dat
Description: Xg.dat

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