External Email - Use Caution Dear experts, I would like to run mri_glmfit in a group analysis. However, I met the following error when I added the medicationload as variable in my fsgd file. Since I have 305 subjects and only 75 of these have medication load, it seems to this variable includes too many zero. Just I guess. The error: ERROR: matrix is ill-conditioned or badly scaled, condno = 1e+08\ \ \ --------------------------------\ -------- ERROR: READ THIS -----------------\ --vvvvvvvvvvvvvvvvvvvvvvvvvvvvvv-----\ Possible problem with experimental design:\ Check for duplicate entries and/or lack of range of\ continuous variables within a class.\ If you seek help with this problem, make sure to send:\ 1. Your command line:\ mri_glmfit --y lh.volume.BDHC3Study.10.mgh --fsgd FSGD/BDHC3Study.fsgd --C Contrasts/HC3-BD3.mtx --C Contrasts/BD3-HC3.mtx --surf fsaverage lh --cortex --glmdir lh.volume.BDHC3Study.10.glmdir \ 2. The terminal output of this program (ie, everything it prints to the screen)\ 3. The FSGD file (FSGD/BDHC3Study.fsgd)\ 4. The design matrix lh.volume.BDHC3Study.10.glmdir/Xg.dat\ Attempting to diagnose further \ SumSq: Min=6.368664 (col 8), Max=16.261612 (col 7)\ ... could not determine the cause of the problem\ --^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^----\ }
I attached my terminal output, fsgd file, and design matrix Thanks Yuan
BDHC3Study.fsgd
Description: BDHC3Study.fsgd
{\rtf1\ansi\ansicpg936\cocoartf2578 \cocoatextscaling0\cocoaplatform0{\fonttbl\f0\fnil\fcharset0 AndaleMono;} {\colortbl;\red255\green255\blue255;\red228\green225\blue224;\red0\green0\blue0;} {\*\expandedcolortbl;;\cspthree\c91229\c90457\c90129;\csgray\c0\c90000;} \paperw11900\paperh16840\margl1440\margr1440\vieww11520\viewh8400\viewkind0 \pard\tx560\tx1120\tx1680\tx2240\tx2800\tx3360\tx3920\tx4480\tx5040\tx5600\tx6160\tx6720\pardirnatural\partightenfactor0 \f0\fs24 \cf2 \cb3 \CocoaLigature0 yuan@macbook-pro-4 struct % tcsh runGLMs_Step2.sh BDHC3Study\ gdfRead(): reading FSGD/BDHC3Study.fsgd\ INFO: demeaning continuous variables\ Continuous Variable Means (all subjects)\ 0 age 24.1115 7.32707\ 1 edu 15.4131 3.21673\ 2 medicationload 0.75082 1.46775\ 3 tiv 1.52969e+06 162728\ Class Size and Means of each Continuous Variable\ 1 BD 150 22.6667 13.8733 1.5267 1534142.9100 \ 2 HC 155 25.5097 16.9032 0.0000 1525383.7726 \ INFO: gd2mtx_method is dods\ Reading source surface /Volumes/structrual/subject_struct/struct/fsaverage/surf/lh.white\ Number of vertices 163842\ Number of faces 327680\ Total area 65416.984375\ AvgVtxArea 0.399269\ AvgVtxDist 0.721953\ StdVtxDist 0.195470\ \ 7.2.0\ cwd /Volumes/structrual/subject_struct/struct\ cmdline mri_glmfit --y lh.volume.BDHC3Study.10.mgh --fsgd FSGD/BDHC3Study.fsgd --C Contrasts/HC3-BD3.mtx --C Contrasts/BD3-HC3.mtx --surf fsaverage lh --cortex --glmdir lh.volume.BDHC3Study.10.glmdir \ sysname Darwin\ hostname 192.168.1.2\ machine x86_64\ user caoyuan\ FixVertexAreaFlag = 1\ UseMaskWithSmoothing 1\ OneSampleGroupMean 0\ y /Volumes/structrual/subject_struct/struct/lh.volume.BDHC3Study.10.mgh\ logyflag 0\ usedti 0\ FSGD FSGD/BDHC3Study.fsgd\ labelmask /Volumes/structrual/subject_struct/struct/fsaverage/label/lh.cortex.label\ maskinv 0\ glmdir lh.volume.BDHC3Study.10.glmdir\ IllCondOK 0\ ReScaleX 1\ DoFFx 0\ Creating output directory lh.volume.BDHC3Study.10.glmdir\ Loading y from /Volumes/structrual/subject_struct/struct/lh.volume.BDHC3Study.10.mgh\ ... done reading.\ INFO: gd2mtx_method is dods\ Saving design matrix to lh.volume.BDHC3Study.10.glmdir/Xg.dat\ Computing normalized matrix\ Normalized matrix condition is 1e+08\ Design matrix ------------------\ 1.00000 0.00000 -0.28817 0.00000 0.18245 0.00000 0.16977 0.00000 -0.24993 0.00000;\ 1.00000 0.00000 -0.42465 0.00000 0.18245 0.00000 0.85108 0.00000 -0.28781 0.00000;\ 1.00000 0.00000 -0.69762 0.00000 0.18245 0.00000 -0.51154 0.00000 0.15378 0.00000;\ 1.00000 0.00000 -1.24354 0.00000 -1.68280 0.00000 -0.51154 0.00000 -0.73881 0.00000;\ 1.00000 0.00000 -0.83410 0.00000 -1.06105 0.00000 1.53240 0.00000 0.72956 0.00000;\ 1.00000 0.00000 0.66719 0.00000 0.18245 0.00000 -0.51154 0.00000 -2.78624 0.00000;\ 1.00000 0.00000 -0.01521 0.00000 0.49332 0.00000 -0.51154 0.00000 -0.02288 0.00000;\ 1.00000 0.00000 -0.69762 0.00000 -0.75018 0.00000 1.53240 0.00000 -1.87276 0.00000;\ 1.00000 0.00000 -0.28817 0.00000 0.18245 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0.00000 0.80367 0.00000 0.80420 0.00000 -0.51154 0.00000 0.31165;\ --------------------------------\ ERROR: matrix is ill-conditioned or badly scaled, condno = 1e+08\ \ \ --------------------------------\ -------- ERROR: READ THIS -----------------\ --vvvvvvvvvvvvvvvvvvvvvvvvvvvvvv-----\ Possible problem with experimental design:\ Check for duplicate entries and/or lack of range of\ continuous variables within a class.\ If you seek help with this problem, make sure to send:\ 1. Your command line:\ mri_glmfit --y lh.volume.BDHC3Study.10.mgh --fsgd FSGD/BDHC3Study.fsgd --C Contrasts/HC3-BD3.mtx --C Contrasts/BD3-HC3.mtx --surf fsaverage lh --cortex --glmdir lh.volume.BDHC3Study.10.glmdir \ 2. The terminal output of this program (ie, everything it prints to the screen)\ 3. The FSGD file (FSGD/BDHC3Study.fsgd)\ 4. The design matrix lh.volume.BDHC3Study.10.glmdir/Xg.dat\ Attempting to diagnose further \ SumSq: Min=6.368664 (col 8), Max=16.261612 (col 7)\ ... could not determine the cause of the problem\ --^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^----\ }
mri_glmfit.log
Description: mri_glmfit.log
Xg.dat
Description: Xg.dat
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