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Hi Iman,

That is extremely helpful, thank you very much (also the paper is a great read)!

Best,
Panos


From: freesurfer-boun...@nmr.mgh.harvard.edu 
<freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of Aganj, Iman 
<iag...@mgh.harvard.edu>
Date: Thursday, April 21, 2022 at 12:06 PM
To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Subject: [External] Re: [Freesurfer] Cortical depth at each cortical voxel
Hi Panos,

You can do such a volumetric analysis using this toolbox:

Code:  
https://secure-web.cisco.com/1oJon4iAO4isIZvwWqv_SPrbgP1nuymBPlmzJ04smF8oIHtaRLpLN3bzbt3juCbgTXNCJas6g9nyfV6L2fle3sIF8pnDCQyPZ_1d23OdRRmjBNJNyQElfC_mznZvyE6EF0H7BZ__qPuxZntCjAjLpXCn_uERFMUD9zHRVRzY7giCtzcSHVijM7ywrr31-RT8VTab-A-cYtuonP7yJbHJAIFpRVbbdoV9uv_ODLhciyjeW1M-YZra3niqP6DEqTGT6_aBdGaGjKJ6P1D5B8kZwymMkmTbc6P2_SMQq8cFUMVGDVpQYjKj1rpHMcLpzWbMSgSdwouChPnUP6AD39uru4A/https%3A%2F%2Fwww.nitrc.org%2Fprojects%2Fthickness
Paper:  
https://secure-web.cisco.com/1cFg41irp8ShMgRWIYqKb-ZWQAzKyBxVRzb22PE0nbtM_LBbxQ3egWpbD8dFzVODcUcuzkCLvvJYMQk3-E9mBmVfGH1heGJnOAxKJ_v6NBiLubQZgNJktM1GysMyyC9qSCbd0YRXK4B9ytqmrKE_ChDUxO7gF3qFXTQ41aBiSdu-5DoljkGfztMMMt6GlK4sb-XRyGWpdm6-pMBH0llEe55hQyo18k_M3FLQRhhl4tz0nPAEuV9GQMBE788n-9dZzy1AT0yo9SH2o14qY8JHs9xURHHHrZBsrwT45wtMfeWjtHg1gxIwRS34ViUC7thxXcac_KTtP08YKyQwl4lLaXw/https%3A%2F%2Fonlinelibrary.wiley.com%2Fdoi%2Fepdf%2F10.1002%2Fhbm.20740

You can apply the MLI_thickness function to the gray matter (soft or binary) 
mask, which returns the layer thickness at each voxel (Thickness) and the 
distance of each voxel to the center of the layer (SkeletonDistance). Cortical 
depth would then be SkeletonDistance at the given voxel subtracted from half of 
Thickness (at the voxel, or preferably on the skeleton for better accuracy). A 
tutorial is included in the EXAMPLE file.

Best,
Iman

From: freesurfer-boun...@nmr.mgh.harvard.edu 
<freesurfer-boun...@nmr.mgh.harvard.edu> On Behalf Of Fotiadis, Panagiotis
Sent: Thursday, April 21, 2022 11:48 AM
To: freesurfer@nmr.mgh.harvard.edu
Subject: [Freesurfer] Cortical depth at each cortical voxel

Hi FS experts,

I was wondering whether there was a way to assign each cortical voxel within 
the T1w (volumetric) scan an index corresponding to its “cortical depth.” I 
have essentially taken the cortical ribbon .mgz file, assigned each cortical 
voxel a voxel ID, and wanted to associate each ID with its corresponding 
cortical depth. I would normally use the *h.sulc files but I didn’t think this 
would properly translate here since it’s a volumetric analysis.

Thank you in advance for your time and help!

Best
Panos

--
Panagiotis Fotiadis
Ph.D. Candidate | Neuroscience Graduate Group
Perelman School of Medicine, University of Pennsylvania



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