Probably the easiest thing to do since you have only two time points is
to compute the difference between the two, then just do a simple group
analysis where you include the covariates that you want.
On 3/23/2022 10:00 AM, Agurne Sampedro Calvete wrote:
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Dear FreeSurfer experts,
I am doing a repeated measures ANOVA 2x2 (2 groups and 2 time points)
and I would like to include in the analysis a covariate that is
constant over the 2 times (e.g., baseline medication).
I would like to see a "group x time x covariate" interaction.
What should the design look like? I know that without covariate the
design is as follows:
GroupDescriptorFile 1
Class Subject1
Class Subject2
Variables Tp1vsTp2.Group1 Tp1vsTp2.Grroup2
Input Subject1_time1 Subject1 1 0
Input Subject1_time2 Subject1 -1 0
Input Subject2_time1 Subject2 0 1
Input Subject2_time2 Subject02 0 -1
Design matrix:
1 0 1 0
1 0 -1 0
0 1 0 1
0 1 0 -1
Contrasts (.mtx files):
Tp1vsTp2.Group1 0 0 1 0
Tp1vsTp2.Group2 0 0 0 -1
Interaction (timexgroup) 0 0 1 -1
However, I do not know how I could include the interaction with that
covariate.
Thank you very much in advance.
Kind regards,
Agurne
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