External Email - Use Caution Dear Kersten,
Thank you for your answer, I have some follow-up questions to the first two points before I can move on. 1) Regarding family-relation, since three random effects may not work, did you mean that a simpler model with 2 random effects (intercept and family ID, thus leaving out slope which I assume is time from baseline) would work? While forgetting family ID is an option, it would be a model that may attract criticism. 2) Regarding multiple comparison correction, I understand how to perform the procedure you suggested (second option) to simply calculate the corrected p threshold using pcor = -log10(pth) and then use pcor as threshold for the sig.mgh. However after running FDR2: [detvtx,sided_pval,pth] = lme_mass_FDR2(F_lhstats.pval,F_lhstats.sgn,lhcortex,0.05,0); While detvtx is not empty (a few vertexes survived) and the pth value is calculated to 1.00000e-30 and therefore pcor to 30. This doesn’t seem right. What is also strange is that I saw a few times a more reasonable pth in the range of e-5 using the exact same data and procedure. I cannot replicate this in the same analysis in R2021, now I only get the e-30 (I only tried left cortex thickness so far). Best, Julian _______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Mass General Brigham Compliance HelpLine at https://www.massgeneralbrigham.org/complianceline <https://www.massgeneralbrigham.org/complianceline> . Please note that this e-mail is not secure (encrypted). If you do not wish to continue communication over unencrypted e-mail, please notify the sender of this message immediately. Continuing to send or respond to e-mail after receiving this message means you understand and accept this risk and wish to continue to communicate over unencrypted e-mail.
