External Email - Use Caution        

Hi Doug

I think I figured out my answer.  ADNI does 4 volume Amyloid PET analyses by 
averaging the 4 volumes together. I do not need to do kinetic modeling. I hope 
this helps someone else in the same situation in the future.

Thanks!
Warm regards,


Jennifer Bramen, PhD
(she/her/hers)
Senior Research Scientist, Neuroimaging
Assistant Professor
Pacific Brain Health Center | Pacific Neuroscience Institute & Foundation | 
Providence Saint John's Health Center
1301 20th St. #150 Santa Monica, CA 90404



From: <freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of Jennifer Bramen 
<jbra...@pacificneuro.org>
Reply-To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Date: Monday, February 7, 2022 at 9:50 AM
To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Subject: Re: [Freesurfer] PETSurfer: error: MatrixReadTxT: could not scan value 
[1][1]


        External Email - Use Caution
Hi Doug

I think my first question should be “do I need to do KM?”. This is an amyloid 
scan and I want to estimate intensity within regions of interest.  Do I need KM 
to estimate mean intensity?

This is what I know about the timing of the 4 amyloid PET volumes:

5 min (300 sec) – Amyloid Brain

  *   (5 minx 4 beds)
  *   40 min uptake
  *   10 mCi IV injection

Can I just create a mean volume from this image or some other simple metric 
instead of KM?

Thanks for your help.

Warm regards,


Jennifer Bramen, PhD
(she/her/hers)
Senior Research Scientist, Neuroimaging
Assistant Professor
Pacific Brain Health Center | Pacific Neuroscience Institute & Foundation | 
Providence Saint John's Health Center
1301 20th St. #150 Santa Monica, CA 90404


From: <freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of "Douglas N. Greve" 
<dgr...@mgh.harvard.edu>
Reply-To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
Date: Friday, February 4, 2022 at 5:09 AM
To: "freesurfer@nmr.mgh.harvard.edu" <freesurfer@nmr.mgh.harvard.edu>
Subject: Re: [Freesurfer] PETSurfer: error: MatrixReadTxT: could not scan value 
[1][1]

Can you send all the terminal output?  Also, you only have 4 time points in 
time.dat. Is this accurate? It's going to be hard to do KM with 4 time points.
On 1/31/2022 5:00 PM, Jennifer Bramen wrote:

        External Email - Use Caution
Hello FreeSurfer Developers,

I'm attempting to analyze amyloid PET data using  PETSurfer. I am trying to do 
kinetic modeling and I am on the MRTM1 step. I have tried this two ways (one 
using the wiki instructions and the other using the tutorial ROI-based approach)

mri_glmfit --y $PET_DIR/PREV_019/gtmpvc.output/km.hb.tac.nii.gz --mrtm1 
$PET_DIR/PREV_019/gtmpvc.output/km.ref.tac.dat $PET_DIR/time.dat --o mrtm1 
--no-est-fwhm --nii.gz; done


 mri_glmfit --y $PET_DIR/PREV_019/gtmpvc.output/gtm.nii.gz --mrtm1 
$PET_DIR/PREV_019/gtmpvc.output/km.ref.tac.dat $PET_DIR/time.dat --o 
$PET_DIR/PREV_019/mrtm1.roi --nii.gz;done

Both times I get this error:

error: MatrixReadTxT: could not scan value [1][1]

I have opened all of the .dat files using my text editor (nano) and they seem 
ok. I have tried this in other subjects and I get the same error.

I searched the list and I cannot find any discussion regarding this error using 
mri_glmfit and PET data.  Anything you can do to help me troubleshoot this 
error would be greatly appreciated!!! Attached is my time.dat file (I think 
this is the most likely culprit).




Warm regards,


Jennifer Bramen, PhD
(she/her/hers)
Senior Research Scientist, Neuroimaging
Assistant Professor
Pacific Brain Health Center | Pacific Neuroscience Institute & Foundation | 
Providence Saint John's Health Center









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