I see what you mean, though I don't think either one look that great. The first thing to do is to backup and look at the registration to fsaverage_sym by mapping the lh and rh curv to lh.fsaverage_sym and see if the curv patterns match up with those in fsaverage_sym and to each other (use mris_apply_reg)

On 11/20/2021 12:34 PM, Dr. Cornelius Kronlage wrote:
         External Email - Use Caution

Dear freesurfer community,

concerning interhemispheric registration: What are differences between 
mris_left_right_register and the xhemi pipeline (including the fsaverage_sym 
subject)? I understand that xhemi/fsaverage_sym are meant to provide an 
unbiased reference as opposed to simply mapping all data to one hemisphere.

I am trying to map a label from one hemisphere to the other on individual 
subjects. I noticed that mris_left_right_register results in output quite 
different from using fsaverage_sym via the xhemi process as an intermediate. As 
an example, see the figure file attached (original label on rh, mapped labels 
on lh). At the first glance, the output of mris_left_right_register seems to 
align with the curvature a lot better...

For reference, the following code was used. Is that correct?
surfreg --s ${subject} --t fsaverage_sym
surfreg --s ${subject} --t fsaverage_sym --lh --xhemi
mris_apply_reg \
   --src-label rh.label --trg rh_on_lh.xhemi.label \
   --streg ${SUBJECTS_DIR}/${subject}/xhemi/surf/lh.fsaverage_sym.sphere.reg 
${SUBJECTS_DIR}/${subject}/surf/lh.fsaverage_sym.sphere.reg

mris_left_right_register \
   ${SUBJECTS_DIR}/${subject}/surf/lh.sphere \
   ${SUBJECTS_DIR}/${subject}/surf/rh.sphere \
   ${SUBJECTS_DIR}/${subject}/surf/lh.sphere.left_right \
   ${SUBJECTS_DIR}/${subject}/surf/rh.sphere.left_right
mris_apply_reg \
   --src-label rh.label --trg rh_on_lh.left_right.label \
   --streg ${SUBJECTS_DIR}/${subject}/surf/rh.sphere.left_right 
${SUBJECTS_DIR}/${subject}/surf/lh.sphere.left_right

Thank you and
with best wishes
Cornelius


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