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Hi Bruce,

Thank you very much for your answer.

Kind regards,
Rosie




On Sun, Nov 21, 2021 at 8:04 PM Fischl, Bruce <bfis...@mgh.harvard.edu>
wrote:

> Hi Rosie
>
>
>
> It really depends on what your hypotheses are, but if you are covarying
> for age and gender in thickness you probably want to do so in an analysis
> of volume as well. The only real difference are (1) thickness doesn’t
> really need TBV covariation, and (2) thickness is a more localizable
> quantity than volume. Of course they are different neurobiologically as
> well, but from an analysis standpoint those are the two big differences
>
> Bruce
>
>
>
> *From:* freesurfer-boun...@nmr.mgh.harvard.edu <
> freesurfer-boun...@nmr.mgh.harvard.edu> *On Behalf Of *Rosalia Dacosta
> Aguayo
> *Sent:* Sunday, November 21, 2021 1:42 PM
> *To:* Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
> *Subject:* [Freesurfer] Basic question
>
>
>
> *        External Email - Use Caution        *
>
> Dear Freesurfer team,
>
>
>
> I know this is a basic question, but I would like to be sure before
> proceeding. Are those statements below right?
>
>
>
> For cortical thickness, I should covariate for age and sex
>
>
>
> For volume, I should covariate only for TBV
>
>
>
> Thank you for your time and your patience.
>
>
>
> Best wishes,
>
> Rosie
>
>
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