External Email - Use Caution        

Hi Eugenio,

The command that was run is segmentHA_T1.sh.

I've rerun and copy-n-pasted the entire session below.

"...

chesterk@selma:~$ source SetUpFreeSurfer_mac.sh
-------- freesurfer-darwin-macOS-7.1.0-20200511-813297b --------
Setting up environment for FreeSurfer/FS-FAST (and FSL)
FREESURFER_HOME   /Applications/freesurfer_v7.1.0
FSFAST_HOME       /Applications/freesurfer_v7.1.0/fsfast
FSF_OUTPUT_FORMAT nii.gz
SUBJECTS_DIR      /Users/chesterk/subjects
MNI_DIR           /Applications/freesurfer_v7.1.0/mni
FSL_DIR           /usr/local/fsl_v6.0.4
chesterk@selma:~$ cd subjects
chesterk@selma:~/subjects$ segmentHA_T1.sh 1001126copy
#--------------------------------------------
#@# Hippocampal Subfields processing (T1) left Fri 11 Jun 2021 11:25:12
AEST
------------------------------------------
Setting up environment variables
---
DYLD_LIBRARY_PATH is
.:/Applications/freesurfer_v7.1.0/MCRv84//runtime/maci64:/Applications/free
surfer_v7.1.0/MCRv84//bin/maci64:/Applications/freesurfer_v7.1.0/MCRv84//sy
s/os/maci64:/Applications/freesurfer_v7.1.0/lib/gcc/lib:/Applications/frees
urfer_v7.1.0/lib/gcc/lib:/Applications/freesurfer_v7.1.0/lib/gcc/lib
/Applications/freesurfer_v7.1.0/bin/run_segmentSubjectT1_autoEstimateAlveus
ML.sh: line 33: 
/Applications/freesurfer_v7.1.0/bin/segmentSubjectT1_autoEstimateAlveusML.a
pp/Contents/MacOS/segmentSubjectT1_autoEstimateAlveusML: No such file or
directory
Darwin selma.nnf.unimelb.edu.au 17.4.0 Darwin Kernel Version 17.4.0: Tue
Dec 19 10:52:05 PST 2017; root:xnu-4570.47.16~1/RELEASE_X86_64 x86_64


T1 hippocampal subfields exited with ERRORS at Fri 11 Jun 2021 11:25:12
AEST


For more details, see the log file
/Users/chesterk/subjects/1001126copy/scripts/hippocampal-subfields-T1.log


chesterk@selma:~/subjects$ more
1001126copy/scripts/hippocampal-subfields-T1.log
------------------------------
USER chesterk
HOST selma.nnf.unimelb.edu.au
PROCESSID 37954 
PROCESSOR x86_64
OS Darwin
ITK_GLOBAL_DEFAULT_NUMBER_OF_THREADS 1
Darwin selma.nnf.unimelb.edu.au 17.4.0 Darwin Kernel Version 17.4.0: Tue
Dec 19 10:52:05 PST 2017; root:xnu-4570.47.16~1/RELEASE_X86_64 x86_64
------------------------------
 
freesurfer-darwin-macOS-7.1.0-20200511-813297b
 
setenv SUBJECTS_DIR /Users/chesterk/subjects
cd /Users/chesterk/subjects
/Applications/freesurfer_v7.1.0/bin/segmentHA_T1.sh 1001126copy


#--------------------------------------------
#@# Hippocampal Subfields processing (T1) left Fri 11 Jun 2021 11:25:12
AEST
------------------------------------------
Setting up environment variables
---
DYLD_LIBRARY_PATH is
.:/Applications/freesurfer_v7.1.0/MCRv84//runtime/maci64:/Applications/free
surfer_v7.1.0/MCRv84//bin/maci64:/Applications/freesurfer_v7.1.0/MCRv84//sy
s/os/maci64:/Applications/freesurfer_v7.1.0/lib/gcc/lib:/Applications/frees
urfer_v7.1.0/lib/gcc/lib:/Applications/freesurfer_v7.1.0/lib/gcc/lib
/Applications/freesurfer_v7.1.0/bin/run_segmentSubjectT1_autoEstimateAlveus
ML.sh: line 33: 
/Applications/freesurfer_v7.1.0/bin/segmentSubjectT1_autoEstimateAlveusML.a
pp/Contents/MacOS/segmentSubjectT1_autoEstimateAlveusML: No such file or
directory
Darwin selma.nnf.unimelb.edu.au 17.4.0 Darwin Kernel Version 17.4.0: Tue
Dec 19 10:52:05 PST 2017; root:xnu-4570.47.16~1/RELEASE_X86_64 x86_64


T1 hippocampal subfields exited with ERRORS at Fri 11 Jun 2021 11:25:12
AEST


..."

Please let me know if I can provide any other details.
Thanks!


Regards,
Chester





On 10/6/21, 12:51 am, "freesurfer-boun...@nmr.mgh.harvard.edu on behalf of
freesurfer-requ...@nmr.mgh.harvard.edu"
<freesurfer-boun...@nmr.mgh.harvard.edu on behalf of
freesurfer-requ...@nmr.mgh.harvard.edu> wrote:

>External email: Please exercise caution
>
>Send Freesurfer mailing list submissions to
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>
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>.mgh.harvard.edu
>or, via email, send a message with subject or body 'help' to
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>
>When replying, please edit your Subject line so it is more specific
>than "Re: Contents of Freesurfer digest..."
>
>
>Today's Topics:
>
>   1. Re: Hippocampal Subfields error "no such file or
>      directory"/"dyld library not loaded" (Iglesias Gonzalez, Juan E.)
>   2. Ill-Conditioned/Badly Scaled Matrix Error (Lurie, Lucy)
>   3. LGI FS 7.1 (Del Re, Elisabetta)
>   4. mri_glmfit with pvr (std...@virgilio.it)
>   5. Re: FW:  WM or Pial edits to correct surfaces (Fischl, Bruce)
>
>
>----------------------------------------------------------------------
>
>Message: 1
>Date: Wed, 9 Jun 2021 12:24:19 +0000
>From: "Iglesias Gonzalez, Juan E." <jiglesiasgonza...@mgh.harvard.edu>
>Subject: Re: [Freesurfer] Hippocampal Subfields error "no such file or
>       directory"/"dyld library not loaded"
>To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
>Message-ID: <8419d11c-c916-4249-9983-557a25229...@mgh.harvard.edu>
>Content-Type: text/plain; charset="us-ascii"
>
>Dear Chester,
>What command did you exactly run? There seems to be a mix of T1 and
>T1+additionalMRI segmentation commands in there.
>Cheers,
>/Eugenio
>
>Juan Eugenio Iglesias
>Senior research fellow
>CMIC (UCL), MGH (HMS) and CSAIL (MIT)
>http://secure-web.cisco.com/1qi_706jGqyyM3M3yDYUokzl_m0IkJHWaqcVYgXiltKvmf2sZt9X-pyYSQmncbstu3rICy2Z7fHggRXk-aKCs7Fr-HTjpj0zQ6tCKLBMJ8qQlxpHWzL3Pl8OR-xTpN-F23znGzhgWE7K9yMHxIKC4JDu_uhiU4UqXswGp7DW6ImpICnIp2rAN9sjKc2johSTK9aRjCmaxJgCb5oKn4sJyy6IbRQBmyVceflyPgKIXagCBaIcBUNYGwHkmdx9RCUleJuy7MjerHcAPxmXS2QZAAA/http%3A%2F%2Fwww.jeiglesias.com
>s.com 
>
>> On Jun 9, 2021, at 00:23, Chester Kang <ckk...@unimelb.edu.au> wrote:
>> 
>>        External Email - Use Caution
>> 
>> Hello FreeSurfer Developers,
>> 
>> I am trying to run subfield segmentation of the hippocampus using
>>Freesurfer v7.1.0. Recon-all has been previously run on all subjects,
>>however with a different version of Freesurfer (v5.3.0).
>> 
>> Getting the error(s): "No such file or directory" and on further
>>investigation "dyld: Library not loaded: @rpath/libmwlaunchermain.dylib"
>> 
>> I've searched the archive but could not find a solution.
>> 
>> Could someone please help?
>> 
>> Below are details of the system and unsuccessful troubleshooting
>>attempts.
>> 
>> Regards,
>> Chester
>> 
>> 
>> FreeSurfer version: 7.1.0
>> Platform: Mac OS 10.13.3
>> hippocampal-subfields-T1.log is below:
>> 
>> Things that have been checked/tried or troubleshooting attempted:
>> - SIP protection is disabled (csrutil status shows "disabled")
>> - Checked that there are files and correct permissions in the
>>"lib/gcc/lib" and the "MCRv84" folders
>> - tried to unset DYLD_LIBRARY_PATH (in the SetUpFreeSurfer.sh)
>> - checked the DYLD_LIBRARY_PATH value and run a step directly (both
>>with "" empty value and the values below)
>> 
>> $ echo $DYLD_LIBRARY_PATH
>> 
>> 
>>.:/Applications/freesurfer_v7.1.0/MCRv84//runtime/maci64:/Applications/fr
>>eesurfer_v7.1.0/MCRv84//sys/os/maci64:/Applications/freesurfer_v7.1.0/lib
>>/gcc/lib
>> 
>> $ 
>>/Applications/freesurfer_v7.1.0/bin/segmentSubjectT1T2_autoEstimateAlveus
>>ML.app/Contents/MacOS/segmentSubjectT1T2_autoEstimateAlveusML
>> 
>> 
>>/Applications/freesurfer_v7.1.0/bin/segmentSubjectT1T2_autoEstimateAlveus
>>ML.app/Contents/MacOS/segmentSubjectT1T2_autoEstimateAlveusML
>> dyld: Library not loaded: @rpath/libmwlaunchermain.dylib
>>  Referenced from:
>>/Applications/freesurfer_v7.1.0/bin/segmentSubjectT1T2_autoEstimateAlveus
>>ML.app/Contents/MacOS/segmentSubjectT1T2_autoEstimateAlveusML
>>  Reason: image not found
>> Abort trap: 6
>> 
>> 
>> 
>> === hippocampal-subfields-T1.log ===
>> 
>> 
>> "...
>> ------------------------------
>> USER chester
>> HOST selma.nnf.unimelb.edu.au
>> PROCESSID 17656 
>> PROCESSOR x86_64
>> OS Darwin
>> ITK_GLOBAL_DEFAULT_NUMBER_OF_THREADS 1
>> Darwin selma.nnf.unimelb.edu.au 17.4.0 Darwin Kernel Version 17.4.0:
>>Tue Dec 19 10:52:05 PST 2017; root:xnu-4570.47.16~1/RELEASE_X86_64 x86_64
>> ------------------------------
>> 
>> freesurfer-darwin-macOS-7.1.0-20200511-813297b
>> 
>> setenv SUBJECTS_DIR /data/netapp02/work/chester/global_pass_all
>> cd /data/netapp02/work/chester/global_pass_all
>> /Applications/freesurfer_v7.1.0/bin/segmentHA_T1.sh 1002310
>> 
>> #--------------------------------------------
>> #@# Hippocampal Subfields processing (T1) left Tue  8 Jun 2021 15:25:15
>>AEST
>> ------------------------------------------
>> Setting up environment variables
>> ---
>> DYLD_LIBRARY_PATH is
>>.:/Applications/freesurfer_v7.1.0/MCRv84//runtime/maci64:/Applications/fr
>>eesurfer_v7.1.0/MCRv84//bin/maci64:/Applications/freesurfer_v7.1.0/MCRv84
>>//sys/os/maci64:/Applications/freesurfer_v7.1.0/lib/gcc/lib
>> 
>>/Applications/freesurfer_v7.1.0/bin/run_segmentSubjectT1_autoEstimateAlve
>>usML.sh: line 33:
>>/Applications/freesurfer_v7.1.0/bin/segmentSubjectT1_autoEstimateAlveusML
>>.app/Contents/MacOS/segmentSubjectT1_autoEstimateAlveusML: No such file
>>or directory
>> Darwin selma.nnf.unimelb.edu.au 17.4.0 Darwin Kernel Version 17.4.0:
>>Tue Dec 19 10:52:05 PST 2017; root:xnu-4570.47.16~1/RELEASE_X86_64 x86_64
>> 
>> T1 hippocampal subfields exited with ERRORS at Tue  8 Jun 2021 15:25:16
>>AEST
>> 
>> ..."
>> 
>> 
>> 
>> 
>> _______________________________________________
>> Freesurfer mailing list
>> Freesurfer@nmr.mgh.harvard.edu
>> 
>>https://secure-web.cisco.com/11QCqR7prxSgfCTvoUKKRK8tL2ls0hM_Sfukn_muBU55xcSMJPqXDZFUSjeQEc7GUksz7UA7hK4WrhUxAAdArGsQ_H7pjdgMBn9dbETcqUKC4nU357BLPcIjkc7x61EuAFLhIH-woON0i0o50lv4_Cci4otwMIPGJWJ7t4uPBcCf4yg1AOGzFogJh6Sj9cAunjzvngYZNEIiSps-Xk5vW9W1IDWpuAn6GXLsEa5i86eXXjQ_RHgOrIT_tbiKvXCUhNzjxH8YeiTRm-ieQB-UUCg/https%3A%2F%2Fmail.nmr.mgh.harvard.edu%2Fmailman%2Flistinfo%2Ffreesurfer
>>.mgh.harvard.edu
>
>
>
>
>------------------------------
>
>Message: 2
>Date: Wed, 9 Jun 2021 13:09:17 +0000
>From: "Lurie, Lucy" <llu...@email.unc.edu>
>Subject: [Freesurfer] Ill-Conditioned/Badly Scaled Matrix Error
>To: "freesurfer@nmr.mgh.harvard.edu" <freesurfer@nmr.mgh.harvard.edu>
>Message-ID: <3bcd8ea8-8da7-4a8a-ba82-8b7a4f2d2...@ad.unc.edu>
>Content-Type: text/plain; charset="utf-8"
>
>        External Email - Use Caution
>
>Hello
>
>I am trying to a whole brain analysis with one group and five covariates.
>I am getting an error that the design matrix may be ill-conditioned or
>badly scaled. I checked over the fsgd file in TextEdit and it seems to be
>formatted correctly. I am using Freesurfer version 5.3.0 and my platform
>is macOS Big Sur version 11.4. I would appreciate any help further
>troubleshooting this error. Thank you!
>
>ERROR: matrix is ill-conditioned or badly scaled, condno = 13065
>Possible problem with experimental design: Check for duplicate entries
>and/or lack of range of continuous variables within a class. If you seek
>help with this problem, make sure to send:
>1. Your command line: mri_glmfit --y
>lh.eig_cgORCE_baselineORCE_teenCG.thickness.10.mgh --fsgd
>eig_cgORCE_baselineORCE_teenCG.fsgd dods --C eig_cgORCE3042_slope.mtx --C
>eig_cgORCEbaseline_slope.mtx --C eig_teenCGqual_slope.mtx --surf
>fsaverage lh --cortex --glmdir
>lh.eig_cgORCE_baselineORCE_teenCGagesex.glmdir
>2. The FSGD file (if using one)
>3. And the design matrix
>
>Design matrix ------------------
>1.000   0.000   16.660   2.950   2.200   0.000;
>1.000   0.000   16.960   1.900   2.600   0.000;
>1.000   0.000   17.390   2.450   2.800   0.000;
>1.000   1.000   17.130   2.300   2.500   0.000;
>1.000   1.000   16.980   2.400   2.300   0.000;
>1.000   0.000   17.690   2.200   2.900   0.000;
>1.000   1.000   16.870   2.750   2.900   1.000;
>1.000   0.000   17.570   2.550   1.700   0.000;
>1.000   0.000   17.130   2.150   1.928   0.000;
>1.000   1.000   17.650   2.750   2.200   0.000;
>1.000   1.000   17.210   2.450   2.500   1.000;
>1.000   0.000   15.610   3.100   1.565   1.000;
>1.000   0.000   16.440   2.650   2.300   0.000;
>1.000   1.000   17.350   2.400   2.600   0.000;
>1.000   0.000   16.800   1.600   1.400   0.000;
>1.000   1.000   17.980   2.200   2.300   1.000;
>1.000   1.000   16.890   2.800   1.600   1.000;
>1.000   0.000   16.760   1.100   1.300   0.000;
>1.000   1.000   16.790   2.500   1.400   0.000;
>1.000   1.000   16.620   2.900   2.800   0.000;
>1.000   1.000   16.500   2.500   1.200   0.000;
>1.000   1.000   16.290   2.700   3.200   0.500;
>1.000   0.000   16.440   3.100   2.500   1.000;
>1.000   0.000   17.540   2.100   2.100   1.000;
>1.000   1.000   16.810   1.900   2.600   1.000;
>1.000   0.000   17.110   2.650   2.400   0.000;
>1.000   1.000   16.520   2.000   2.300   0.000;
>1.000   1.000   16.520   3.100   3.400   1.000;
>1.000   0.000   16.320   3.300   2.800   0.500;
>1.000   0.000   16.380   3.200   1.900   1.000;
>1.000   0.000   16.570   2.800   2.000   0.000;
>1.000   1.000   16.250   2.200   1.600   0.000;
>1.000   1.000   16.820   2.900   2.600   1.000;
>1.000   0.000   16.580   2.600   2.800   0.000;
>1.000   1.000   16.730   2.850   3.150   0.000;
>1.000   0.000   16.310   2.600   1.900   0.000;
>1.000   1.000   17.010   1.700   2.400   0.000;
>1.000   1.000   16.360   3.200   3.200   0.000;
>1.000   1.000   16.490   2.400   1.525   0.000;
>1.000   0.000   16.300   2.400   1.450   1.000;
>1.000   0.000   16.060   2.200   1.300   0.000;
>1.000   1.000   16.600   2.200   2.000   0.000;
>1.000   0.000   16.720   3.300   2.500   0.000;
>1.000   1.000   16.160   2.300   2.200   0.000;
>1.000   1.000   16.140   2.800   1.850   0.000;
>1.000   1.000   16.550   3.100   2.950   1.000;
>1.000   1.000   17.300   3.450   2.700   1.000;
>1.000   0.000   16.940   3.000   2.200   1.000;
>1.000   1.000   16.550   2.700   2.850   0.000;
>1.000   0.000   17.170   3.000   2.900   1.000;
>1.000   0.000   17.150   2.800   2.450   0.000;
>1.000   0.000   16.650   3.100   1.900   0.500;
>1.000   0.000   16.070   2.700   2.900   1.000;
>1.000   1.000   16.720   1.800   1.450   1.000;
>1.000   0.000   16.150   2.900   1.000   0.000;
>1.000   1.000   16.120   2.400   2.200   1.000;
>1.000   1.000   17.540   2.600   2.600   0.000;
>1.000   1.000   16.840   2.900   1.100   0.000;
>1.000   1.000   15.790   3.100   1.600   1.000;
>1.000   1.000   16.430   2.800   1.500   0.000;
>1.000   0.000   16.390   3.300   2.700   1.000;
>1.000   0.000   16.480   3.350   3.000   0.000;
>1.000   1.000   16.930   3.000   1.000   0.000;
>1.000   1.000   15.550   2.200   2.600   0.000;
>1.000   1.000   17.080   2.900   1.500   0.000;
>1.000   0.000   16.850   2.500   2.200   0.500;
>1.000   1.000   16.700   2.200   1.800   0.000;
>1.000   1.000   15.930   2.600   2.000   1.000;
>1.000   1.000   16.080   2.600   1.200   0.500;
>1.000   0.000   16.130   3.150   1.400   1.000;
>1.000   1.000   16.250   3.100   1.400   1.000;
>1.000   0.000   16.040   3.250   3.200   1.000;
>1.000   0.000   16.040   3.500   2.900   1.000;
>1.000   0.000   16.070   1.400   1.000   1.000;
>1.000   0.000   16.550   3.200   2.300   1.000;
>1.000   0.000   16.120   2.800   2.000   0.500;
>1.000   1.000   16.450   3.150   1.400   1.000;
>1.000   0.000   15.910   3.400   1.600   1.000;
>1.000   1.000   15.700   3.000   2.400   1.000;
>
>Best,
>Lucy Lurie (she/her/hers)
>Doctoral Student, Clinical Psychology
>Department of Psychology and Neuroscience
>University of North Carolina at Chapel Hill
>CIRCLE 
>Lab<https://secure-web.cisco.com/18i_Rf4fzTTcqPA2OQAm3_CnM6qhNKl6D-xG6RO1PJGAuLnAlN2Qa-m8h9EZGbO9Qo7QPQAiBVNevAoHlY-jf9z7dGHxurd8Oe8uw75EoTaRxQZ_Nl1ObEe1gsWQecXmO42TYy9xWhqpijv4wchCBs6bYGaIXNVDP3iaP_YqG99OQMWqyy3Zhq6_BwSFJYIw_edeT9Drrl9CQKiDWXReHaL-jQ4DUC7cHEyRW7ZG8OXH6a9M8dPLZcaM5Lxb8KEYCKOSgtBx3kUPo_h53ZU-lOQ/https%3A%2F%2Fcirclelab.unc.edu%2F
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>mgh.harvard.edu 
>
>------------------------------
>
>Message: 3
>Date: Wed, 9 Jun 2021 14:17:22 +0000
>From: "Del Re, Elisabetta" <elisabetta_de...@hms.harvard.edu>
>Subject: [Freesurfer] LGI FS 7.1
>To: "freesurfer@nmr.mgh.harvard.edu" <freesurfer@nmr.mgh.harvard.edu>
>Cc: Elisabetta del Re- Harvard <elisabettacde...@gmail.com>
>Message-ID:
>       
> <bl0pr07mb4066c7fbfac7ed9625c69db5b3...@bl0pr07mb4066.namprd07.prod.outlo
>ok.com>
>       
>Content-Type: text/plain; charset="iso-8859-1"
>
>        External Email - Use Caution
>
>Dear FS team,
>what are differences if any between LGI in FS 5.3 and 7.1?
>Thank you so much,
>best wishes,
>Elisabetta
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>mgh.harvard.edu 
>
>------------------------------
>
>Message: 4
>Date: Wed, 9 Jun 2021 16:38:05 +0200 (CEST)
>From: std...@virgilio.it
>Subject: [Freesurfer] mri_glmfit with pvr
>To: "freesurfer@nmr.mgh.harvard.edu" <freesurfer@nmr.mgh.harvard.edu>
>Message-ID: <1340792404.242762.1623249485...@mail1.virgilio.it>
>Content-Type: text/plain; charset="utf-8"
>
>        External Email - Use Caution
>
>Thanks
>
>If I have 4 groups
>
>GroupDescriptorFile 1
>Title XXX
>Class G1
>Class G2
>Class G3
>Class G4
>
>Input subj1 G1
>
>Input subj2 G3
>
>Input subj3 G2
>
>Input subj4 G2
>
>Input subj5 G4
>
>....
>
>
>Are the contrasts below corrected?
>
>G1_only_thick 1 0 0 0
>
>G2_only_thick 1 0 0 0
>
>G3_only_thick 1 0 0 0
>
>G4_only_thick 1 0 0 0
>
>G1+G2-G3+G4_thick 0.5 0.5 -0.5 -0.5
>
>G3+G4+G2+G1_thick -0.5 -0.5 0.5 0.5
>
>G1+G2+G3+G4_thick 0.25 0.25 0.25 0.25
>
>Thanks
>
>Stefano
>
>
>
>Yes, you use a "per-vertex map" (--pvr option to mri_glmfit). See,
>example, this thread
>https://secure-web.cisco.com/1AQW2Zmfaui0gjHDqfC-62qKrikS49RYbR7pNeQeTr2onenw4VdfUzxAD-yIGZ-RWjvqJqELbkeBxh-eEoHsrsM5sjWYXowa55h5HmDwS2HP-LGyy4SFdxgEGV4R5lhBK0pMIf8VhbvlMkoZpaRCGO9sEsN89fc0rgzYL83HiJvCE6vviDul0-oFKliOXHXlXxdd6kqkmidKljGOb8tcDOZX_cjdrLsH7G0YoQYuiemfio9U_qVDhfkyDU2t5DWXRvlVbn_e9Nkc3DJ7h0XjhCA/https%3A%2F%2Fwww.mail-archive.com%2Ffreesurfer%40nmr.mgh.harvard.edu%2Fmsg18790.htmlOn
>b.cisco.com 6/3/2021 10:22 AM, std...@virgilio.it wrote:
>
>> External Email - Use Caution Hi, how can I perform vertex by vertex
>>(surface) analysis of covariance between functional connectivity data
>>(FS-FAST) and cortical thickness, regressing out the effect of groups?My
>>mean concern is how buid the fsgd file. Stefano
>> 
>
>Great news, thank you, Doug! Best, aga On 8/3/11 5:02 PM, "Douglas N
>Greve" <gr...@nmr.mgh.harvard.edu> wrote:
>
>>Hi Aga, what you have done is correct, no need to include the pvr in the
>>fsgd.
>>doug
>>
>>Burzynska, Aga wrote:
>>> Dear all,
>>> I am trying to make group level analysis of functional data on the
>>>surface and add per-vertex regressors (PVR, here: cortical thickness)
>>>into the design. When I view the results I have the feeling that the PVR
>>>is not really included in the model:
>>>
>>> I am using the command:
>>> mri_glmfit --glmdir lh_output --y cope1_lh_4D.mgh --fsgd
>>>Group1versusGroup2.fsgd  --pvr lh.thickness.10.mgh --C
>>>Group1only_thickness.mat --C Group2only_thickness.mat --C
>>>Group1minusGroup2_thickness.mat --C Group2minusGroup1_thickness.mat --C
>>>Group1plusGroup2_thickness.mat
>>>
>>> where
>>> cope1_lh_4D.mgh contains the concatenated sig.mgh images from the fixed
>>>level analysis (combining the runs) for each participant
>>> fsgd file contains:
>>> GroupDescriptorFile 1
>>> Title Group1versusGroup2
>>> Class Group1 
>>> Class Group2
>>> Input     1109     Group1
>>> Input     1110     Group1
>>> Input     1111     Group1
>>> Input     1112     Group1
>>> ...
>>> Input     2280      Group2
>>> Input     2282  Group2
>>> Input     2283  Group2
>>> Input     2284  Group2
>>>
>>> The PVR is a file containing thickness maps for each participant,
>>>concatenated in the same order as for the functional data.
>>>
>>> So there are 2 main regressors (1 factor, 2 levels), but the contrast
>>>files contain 3 regressors (the third one is the PVE), for instance:
>>> Group1minusGroup2_thickness.mat contains  1 -1 0.
>>>
>>> Does it look correct?
>>> Should the pvr regressor be included in the fsdg file? How can I do it?
>>>
>>> Thank you very much for your help,
>>> Cheers,
>>> Aga
>>>
>>> _______________________________________________
>>> Freesurfer mailing list
>>> Freesurfer@nmr.mgh.harvard.edu
>>> 
>>>https://secure-web.cisco.com/1eQw4HlVWpF4ZzzChk-hp9V02K-k7R250ksr-ZRpjXC5ESaaFuyzgAuTFAoGhyEgYrYKrou0EXi_1ri2KpbhLu0RDRiF8JbcjNXFPW9pDzwKVvda8OwJaDhfqmDKW60AffvShgjctqkjGDrtVh3d5g5ibXvHnKxBrCeDpGoDotLpWBCKfctMD7RKY5GYQlCh3Un1XOMnnDFI7_MF2lAwup2vGzl11XZ_ZrOq3M8ZZB588KJPu216UQ-0rXaUfyN9kqO2LvtMM_BKWPkbPWLv1wQ/https%3A%2F%2Fmail.nmr.mgh.harvard.edu%2Fmailman%2Flistinfo%2Ffreesurfer
>>>web.cisco.com
>>>
>>>
>>>   
>>
>>-- 
>>Douglas N. Greve, Ph.D.
>>MGH-NMR Center
>>gr...@nmr.mgh.harvard.edu
>>Phone Number: 617-724-2358
>>Fax: 617-726-7422
>>
>>Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
>>FileDrop: 
>>http://secure-web.cisco.com/1C61OSNwGFU8-MmX4hWZetUP6ivnpYMPZsypGZ1hSjsNzy-brmGySww1ZGhhngrVj1qYbuwE6PRUUeJN-f9A8A1WZ7th0QNfdUhXE6D3hKAkvirUMUgcYjEpbpiqr5EEx-zEFztskyh0Z_s-qx-pZYihOqIa83wP01adMhu1ZWGzu3R2R5BlSU44Kyj-7-8tjs4X0m9YumA2POfACS1X8JuGCd9bbmRQnsPob9yGBPtkb0saYprAkjBM9vSEkN54Sqsr6uuBnkzUu9th-uPKp8g/http%3A%2F%2Fwww.nmr.mgh.harvard.edu%2Ffacility%2Ffiledrop%2Findex.html
>>eb.cisco.com
>>
>>
>>
>>The information in this e-mail is intended only for the person to whom it
>>is
>>addressed. If you believe this e-mail was sent to you in error and the
>>e-mail
>>contains patient information, please contact the Partners Compliance
>>HelpLine at
>>http://secure-web.cisco.com/1SUkt2fsByhbVkrjyleWea7U8vPw7dJUUjO3n73A05t_91lBe900zX8Xj5BXS5FVVIPhPdXp82Z6tn-yeqKFAhUFk_5StCCsEPSU9TJVMOayzf4j0KrCyoFNj-C2OGDP0xFemZL4QAwmVXf6LLrOE9uXSoUkhZAdqVKfMGyQ69ZkTVjm5-iFg90fsEAVNWEfQKIfNgsAMcDyfxfoi3sAh7AkPp30_dgubiPt_de-c2xl98NuTVZv4kCbN3juzQ9BiEeSE28aMxZczxiclrU7Fxg/http%3A%2F%2Fwww.partners.org%2Fcomplianceline
>>eb.cisco.com . If the e-mail was sent to you in
>>error
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>
>
>_______________________________________________
>Freesurfer mailing list
>Freesurfer@nmr.mgh.harvard.edu
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>b.cisco.com
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>mgh.harvard.edu 
>
>------------------------------
>
>Message: 5
>Date: Wed, 9 Jun 2021 14:51:16 +0000
>From: "Fischl, Bruce" <bfis...@mgh.harvard.edu>
>Subject: Re: [Freesurfer] FW:  WM or Pial edits to correct surfaces
>To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
>Message-ID:
>       
> <bl0pr04mb6609fbc2dac7159f549ebf77ef...@bl0pr04mb6609.namprd04.prod.outlo
>ok.com>
>       
>Content-Type: text/plain; charset="us-ascii"
>
>Great, so you are all set then?
>
>From: freesurfer-boun...@nmr.mgh.harvard.edu
><freesurfer-boun...@nmr.mgh.harvard.edu> On Behalf Of Alexopoulos,
>Dimitrios
>Sent: Tuesday, June 8, 2021 10:45 PM
>To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
>Subject: Re: [Freesurfer] FW: WM or Pial edits to correct surfaces
>
>
>        External Email - Use Caution
>
>        External Email - Use Caution
>I simply added additional CPs to the original ones (on the left) .
>
>From: 
>freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.h
>arvard.edu> 
><freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.
>harvard.edu>> On Behalf Of Fischl, Bruce
>Sent: Tuesday, June 08, 2021 3:12 PM
>To: Freesurfer support list
><freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
>Subject: Re: [Freesurfer] FW: WM or Pial edits to correct surfaces
>
>* External Email - Caution *
>You mean before? It was because the normalization was making some of the
>WM intensities so bright that they no longer looked like white matter
>(more like fat or something)
>
>Bruce
>
>From: 
>freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.h
>arvard.edu> 
><freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.
>harvard.edu>> On Behalf Of Alexopoulos, Dimitrios
>Sent: Tuesday, June 8, 2021 4:08 PM
>To: Freesurfer support list
><freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
>Subject: Re: [Freesurfer] FW: WM or Pial edits to correct surfaces
>
>
>        External Email - Use Caution
>
>        External Email - Use Caution
>Bruce, that did the trick, with additional CPs to the WM. See below.
>I'm still not sure why some occipital brain was removed in the brainmask.
>
>
>[cid:image001.jpg@01D75D1D.5C3FD180][cid:image002.jpg@01D75D1D.5C3FD180]
>
>
>
>From: 
>freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.h
>arvard.edu> 
><freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.
>harvard.edu>> On Behalf Of Fischl, Bruce
>Sent: Monday, June 07, 2021 5:30 PM
>To: Freesurfer support list
><freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
>Subject: Re: [Freesurfer] FW: WM or Pial edits to correct surfaces
>
>* External Email - Caution *
>It's really hard to say without looking at your data. You have to be
>careful not to accidentally add CPs outside of brain though as that can
>mess everything up
>Bruce
>
>From: 
>freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.h
>arvard.edu> 
><freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.
>harvard.edu>> On Behalf Of Alexopoulos, Dimitrios
>Sent: Monday, June 7, 2021 6:24 PM
>To: Freesurfer support list
><freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
>Subject: Re: [Freesurfer] FW: WM or Pial edits to correct surfaces
>
>
>        External Email - Use Caution
>
>        External Email - Use Caution
>Thx Bruce,  I'll edit the CPs as you suggest.
>
>How do you explain brain in the updated brainmask being removed in the
>occipital region? I made no edits or changes in that area?.
>Do I need to edit the brainmask by cloning to the T1?
>
>From: 
>freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.h
>arvard.edu> 
><freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.
>harvard.edu>> On Behalf Of Fischl, Bruce
>Sent: Monday, June 07, 2021 3:58 PM
>To: Freesurfer support list
><freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
>Subject: Re: [Freesurfer] FW: WM or Pial edits to correct surfaces
>
>* External Email - Caution *
>p.s. if you are still struggling with this after trying to be more
>conservative we can take a look. The other thing you can try if you want
>to keep your current CP placement is to also add some to the interior of
>the WM (where things are getting to be in the 130s and 140s). This will
>limit the spatial extent of the influence of the CPs that are on the thin
>strands
>
>From: 
>freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.h
>arvard.edu> 
><freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.
>harvard.edu>> On Behalf Of Alexopoulos, Dimitrios
>Sent: Monday, June 7, 2021 4:46 PM
>To: Freesurfer support list
><freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
>Subject: [Freesurfer] FW: WM or Pial edits to correct surfaces
>
>
>        External Email - Use Caution
>
>        External Email - Use Caution
>As a followup to my previous post, here is the aparc+aseg in that same
>region.
>
>[cid:image002.jpg@01D75D1D.5C3FD180][cid:image003.png@01D75D1D.5C3FD180]
>
>
>From: 
>freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.h
>arvard.edu> 
><freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.
>harvard.edu>> On Behalf Of Alexopoulos, Dimitrios
>Sent: Monday, June 07, 2021 3:26 PM
>To: Freesurfer support list
><freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
>Subject: Re: [Freesurfer] WM or Pial edits to correct surfaces
>
>* External Email - Caution *
>
>        External Email - Use Caution
>Bruce,
>
>Thanks for the recommenadtion. I editerd several regions by being more
>aggressive with CPs, whose palcements are shown in
>The snapshots below. The images on the left of each row below are the
>original FS ouputs and on the right are the updated outputs with the CPs
>added and running recon-all -all.
>
>.
>
>Original          
>                  
>     With CPs
>
>In row 1 the the pial and white surrfaces in the frontal pole region in
>many cases look much better. The WM has  pushed  the pial out correctly.
>
>[cid:image004.jpg@01D75D1D.5C3FD180][cid:image005.jpg@01D75D1D.5C3FD180]
>
>
>
>Row 2:
>
>Not so good a result when adding CPS. The frontal pole pial got pulled
>out correctly but the WM surface is incorrect. Suggrestions to correct?
>I aslo noticed that several WM voxels in the updated regions are >110  up
>to 130-140. Is this expected?
>
>[cid:image006.png@01D75D1D.5C3FD180][cid:image007.jpg@01D75D1D.5C3FD180]
>
>
>Row 3:
>
>CPs appear to have captured more WM and the pial got pushed out correctly
>in the lateral orbital region. In this example I'm not sure why the
>occipital pole has data removed in the brainmask. I simply reran
>recoon-all -all incorporating the updated control,dat.
>Do I need to add back brain by cloning with the T1?
>
>[cid:image008.jpg@01D75D1D.5C3FD180][cid:image009.jpg@01D75D1D.5C3FD180]
>
>
>
>
>
>From: 
>freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.h
>arvard.edu> 
><freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.
>harvard.edu>> On Behalf Of Fischl, Bruce
>Sent: Sunday, June 06, 2021 12:59 PM
>To: Freesurfer support list
><freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
>Subject: Re: [Freesurfer] WM or Pial edits to correct surfaces
>
>* External Email - Caution *
>Usually you can do this iteratively. Find some voxels that are clearly
>wm, but whose intensity is <110 and add some cps there then rerun. In the
>image below you could put some near the red cursor, which looks darker
>than the wm more superior
>
>From: 
>freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.h
>arvard.edu> 
><freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.
>harvard.edu>> On Behalf Of Alexopoulos, Dimitrios
>Sent: Sunday, June 6, 2021 1:57 PM
>To: Freesurfer support list
><freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
>Subject: Re: [Freesurfer] WM or Pial edits to correct surfaces
>
>
>        External Email - Use Caution
>
>        External Email - Use Caution
>Bruce,
>
>Below are snapshots of the brainmask and surfaces in that problematic
>region.
>I tried to add some CPs but generally did not because the WM is not
>visible and/or intensity values are ~70. The cortex is just darker in
>this region.
>
>
>[cid:image010.png@01D75D1D.5C3FD180][cid:image011.png@01D75D1D.5C3FD180]
>[cid:image012.jpg@01D75D1D.5C3FD180]
>
>
>From: 
>freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.h
>arvard.edu> 
><freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.
>harvard.edu>> On Behalf Of Fischl, Bruce
>Sent: Sunday, June 06, 2021 10:52 AM
>To: Freesurfer support list
><freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
>Subject: Re: [Freesurfer] WM or Pial edits to correct surfaces
>
>* External Email - Caution *
>Where did you try putting control points? If I understand what you are
>seeing I would add them to the body of the wm near temporal pole, then
>check in the brain.mgz to make sure that the intensities have been
>increased enough (where you put the CPs it should be close to 110, and
>the WM should be >90 or so most places depending on the details of your
>acquisition )
>
>Cheers
>Bruce
>
>From: 
>freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.h
>arvard.edu> 
><freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.
>harvard.edu>> On Behalf Of Alexopoulos, Dimitrios
>Sent: Saturday, June 5, 2021 2:20 PM
>To: Freesurfer support list
><freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
>Subject: Re: [Freesurfer] WM or Pial edits to correct surfaces
>
>
>        External Email - Use Caution
>
>        External Email - Use Caution
>Greg,
>
>I tried what you recommended. I ran several iterations with
>PlaceT1PialSurf --max-cbv-dist 6 (8 and 10), with and without controls
>points. No meaningful changes occur with pulling out the pial and adding
>CPs. In fact the CPS may cause more harm since the intensities are around
>60-70.
>
>The issue  appears  to be intensity-gradient related. The  raw T1 has a
>mild intensity inhomogeneity where the anterior is darker than posterior
>regions, including darker cortex especially  in frontal pole cortex. The
>N3 gain field correction does not appear to have had much on an effect.
>This is illustrated in the images  below. Raw T1 (left), brainmask,
>brainmask/pial surface.
>
>[cid:image013.jpg@01D75D1D.5C3FD180][cid:image014.jpg@01D75D1D.5C3FD180][c
>id:image015.jpg@01D75D1D.5C3FD180]
>
>
>Are there other options with the N3 correction in freesurfer?
>
>Can we input another T1 which has been pre-processed using another
>method, perhaps using  ANTS N4, which appears to do better with the gain
>field correction.
>
>Jim
>
>
>From: 
>freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.h
>arvard.edu> 
><freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.
>harvard.edu>> On Behalf Of Alexopoulos, Dimitrios
>Sent: Friday, May 28, 2021 1:08 PM
>To: Freesurfer support list 
><freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
>Subject: Re: [Freesurfer] WM or Pial edits to correct surfaces
>
>* External Email - Caution *
>
>        External Email - Use Caution
>Thanks Doug. Will try with difference distances. Where is the expert file 
>placed?
>
>From: 
>freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.h
>arvard.edu> 
><freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.
>harvard.edu>> On Behalf Of Douglas N. Greve
>Sent: Thursday, May 27, 2021 5:25 PM
>To: freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>
>Subject: Re: [Freesurfer] WM or Pial edits to correct surfaces
>
>* External Email - Caution *
>There might be a couple things happening. First, I would try adding a few 
>control points in that area; make sure they are in true WM in voxels that 
>have a value less than 110 on the brain.mgz file. This might help push 
>the white surface further out (the WM in that gyrus is very thin). It 
>might also help push the pial surface out. The next thing you can try is 
>to increase the maximum distance over which the edge is searched for. 
>These young subjects have very plump/thick cortices. You can do that with 
>an expert options file. Create a text file with the following content:
>
>   PlaceT1PialSurf --max-cbv-dist 6
>
>Where "6" tells it to search 6 mm rather than the default 5. You may need 
>to play with the number
>
>You can then run recon-all with
>
>recon-all -s subject -expert yourexpertoptions.txt -pial -lh
>
>The above command will run just the pial of just the lh hemi, so you 
>should have your answer in a few minutes
>On 5/27/2021 2:19 PM, Alexopoulos, Dimitrios wrote:
>
>        External Email - Use Caution
>
>        External Email - Use Caution
>
>
>Hi users,
>
>We're having some issues with running some of our 2-3yo data (0.8mm 
>isotropic)  through FS7 with and without the -hires  flag.
>
>There are persistent issues with the frontal lobe regions where the pial 
>has not extended to outer surface as illustrated below.
>The WM surface contour look reasonable but the pial has underestimated 
>the outer cortex resulting in an incorrect surface (below).
>
>I don't think control points will work (low intensity values in the 
>50-60s), and no WM to add to the WM.mgz.
>Any suggestion on how to push the pial surface out to capture the 
>cortical surface??
>
>Thx.
>Jim
>
>[cid:image016.png@01D75D1D.5C3FD180] [cid:image017.jpg@01D75D1D.5C3FD180] 
>[cid:image018.png@01D75D1D.5C3FD180] [cid:image019.png@01D75D1D.5C3FD180] 
>                                                                          
>               &nb sp;
>[cid:image020.png@01D75D1D.5C3FD180][cid:image021.jpg@01D75D1D.5C3FD180]
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>------------------------------
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>End of Freesurfer Digest, Vol 208, Issue 21
>*******************************************
>



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