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Again, thank you for your explanation of how these variables are calculated. 
However, the the main question still left is, are these values the most 
representative of the whole cerebral surface area and the whole cerebral 
thickness for both the left and right hemispheres?

________________________________
From: freesurfer-boun...@nmr.mgh.harvard.edu 
<freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of Douglas N. Greve 
<dgr...@mgh.harvard.edu>
Sent: Monday, August 24, 2020 10:15:10 AM
To: freesurfer@nmr.mgh.harvard.edu
Subject: Re: [Freesurfer] Global surface area and global thickness values 
{Disarmed}

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The average thickness is the average over all the vertices in the cortex.label
The total surface area is the sum of all the triangles that have all three 
corners in the cortex.label

On 8/24/2020 9:35 AM, Palin, Tara wrote:

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I was asking if the Mean Thickness value and the Pial Surface Area values at 
the top of the aparc.stats file that is generated when running freesurfer are 
the global measures. And if they are, I got very close values on multiple 
different apar.stats files by using the Surface Area and AvgThick ROI values 
printed at the bottom of the file. Basically, how are those values stated in 
the first sentence being calculated.


Thank you.

________________________________
From: 
freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.harvard.edu>
 
<freesurfer-boun...@nmr.mgh.harvard.edu><mailto:freesurfer-boun...@nmr.mgh.harvard.edu>
 on behalf of Douglas N. Greve 
<dgr...@mgh.harvard.edu><mailto:dgr...@mgh.harvard.edu>
Sent: Friday, August 21, 2020 6:42:38 PM
To: freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>
Subject: Re: [Freesurfer] Global surface area and global thickness values

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I'm not sure what your question is. You can't just average the ROI values to 
get the global value unless you weight by the ROI size.

On 8/21/2020 2:55 PM, Palin, Tara wrote:

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Hello freesurfer experts,


I am looking to extract the global surface and global thickness measurements 
and am curious if my understanding of the output on the aparc.stats (for lh and 
rh) are correct. When looking at these files, at the very top you will find the 
Pial Surface Total Area and a Mean Thickness value which I am assuming are the 
global measures. Below you have all of the ROIs listed (this was not changed by 
us or generated by us this is what comes out of freesurfer to my understanding) 
that includes everything EXCEPT the corpus callosum and the unknown. However, I 
summed all the surface areas and took and average of all the thickness 
measurements and they are very close to the values printed at the top of the 
sheet. Another observation I had made was that the total surface area 
measurement has a decimal and the surface area for the ROIs appears to be 
rounded and if they were not rounded the values would be the same. For the 
thickness values, the value I calculated and the one on the sheet are within 
the average of the standard deviation each other.


If my understanding is incorrect please let me know and provide insight into 
how we may calculate these global measurements correctly.


Thank you in advance for your time,

Tara Palin



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