How you did you do your analysis? As an exploratory/map-based analysis?
Or as an ROI analysis? How did you correct for multiple comparisons?
Generally, in a map-based analysis, the correction for multiple
comparisons incorporates the fact that there are two hemispheres being
tested.
On 6/20/2020 10:04 PM, xunzhang_hmrrc wrote:
External Email - Use Caution
Hello Freesurfer developers,
Recently, I have used QDEC of freesurfer 6.0.0 to examine the cortical
thickness differences between two groups, and the manuscript has been
submitted to a journal. One reviewer raised a question -"The
manuscript stated that the right and left hemisphere were tested
separately. Could the authors provide an explanation for this? I
assume that testing over 68 (all ROIs) vs testing separately left and
right (34 ROIs) would have an effect?" Unfornately, I don't know how
to responde to this reviewer, so I would like to ask for your help. I
just followed the tutorials of QDEC
(http://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/QdecGroupAnalysisV6.0),
and I found QDEC analyses have always be done for the two hemispheres
separately. So, could you please provide some perspective and citation
about the validation for such design of QDEC?
Thank you in advance for your assistance,
Best regards,
------------------------------------------------------------------------
Xun
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