David and Doug: can you point Prad in the right direction for looking at gray and white signal changes and ratios? On Thu, 28 May 2020, Pradyumna Bharadwaj wrote:


        External Email - Use Caution        

Hi Dr. Fischl,
Thank you for suggesting that. 
Would it be possible to share a link to a page with information about this
stream or to a patch?

Thanks,
Prad

On Thu, May 28, 2020 at 9:46 AM Bruce Fischl <fis...@nmr.mgh.harvard.edu>
wrote:
      External Email

      I see. I think Doug has a more modern stream for this that David
      Salat
      has also used a lot
      On Thu, 28 May 2020, Pradyumna Bharadwaj wrote:

      >
      >         External Email - Use Caution        
      >
      > Hi Dr. Fischl,
      > Thanks for confirming that!
      > We were broadly interested in testing whether age-related
      differences in
      > cortical measures were impacted by the CNR in each ROI.
      >
      > Best,
      > Prad
      >
      > On Thu, May 28, 2020 at 9:33 AM Bruce Fischl
      <fis...@nmr.mgh.harvard.edu>
      > wrote:
      >       External Email
      >
      >       Hi Prad
      >
      >       what is your goal? What you describe below should work
      >
      >       cheers
      >       Bruce
      >       On Thu, 28 May 2020,
      >       Pradyumna Bharadwaj wrote:
      >
      >       >
      >       >         External Email - Use Caution        
      >       >
      >       > Hi Dr. Fischl,
      >       > Thank you for clarifying that!
      >       >
      >       > As a follow up question, I just wanted to double check
      that
      >       the method
      >       > outlined in this post is still a valid approach to
      obtaining
      >       the CNR values
      >       > for each of the ROIs in 
theDesikan-Killianyatlas(https://www.mail-archive.com/freesurfer@nmr.mgh.harva
      rd.edu/msg62066.
      >       html)
      >       > .
      >       >
      >       > Briefly, you recommended converting the aparc
      annotation to
      >       labels in the
      >       > atlas, and applying mri_cnr to each label.
      >       >
      >       > Best,
      >       > Prad
      >       >
      >       > On Thu, May 28, 2020 at 9:14 AM Bruce Fischl
      >       <fis...@nmr.mgh.harvard.edu>
      >       > wrote:
      >       >       External Email
      >       >
      >       >       Hi Prad
      >       >
      >       >       if you use the cortex.label is will avoid using
      the
      >       non-cortical
      >       >       regions in
      >       >       the surface, like the midline, so should be a
      more
      >       accurate
      >       >       measure
      >       >
      >       >       cheers
      >       >       Bruce
      >       >
      >       >
      >       >       On Thu, 28 May 2020, Pradyumna Bharadwaj wrote:
      >       >
      >       >       >
      >       >       >         External Email - Use Caution        
      >       >       >
      >       >       > Hi,
      >       >       >
      >       >       > I had a question about the -label flag in
      mri_cnr.
      >       >       >
      >       >       > 1) When you do not use the -label option and
      just use
      >       the
      >       >       following command:
      >       >       >  mri_cnr $FREESURFER_HOME/subjects/bert/surf 
       
      >       >       $FREESURFER_HOME/subjects/be
      >       >       > rt/mri/norm.mgz
      >       >       >
      >       >       > The output is as follows
      >       >       >
      >       >       >   white = 96.6+-6.0, gray = 75.7+-13.5, csf =
      >       55.3+-16.6
      >       >       gray/white CNR = 1.
      >       >       > 983, gray/csf CNR = 0.907
      >       >       >
      >       >       >  lh CNR = 1.445
      >       >       >
      >       >       > white = 96.4+-6.0, gray = 76.0+-13.3, csf =
      55.6+-16.2
      >       >       gray/white CNR = 1.95
      >       >       > 2, gray/csf CNR = 0.943
      >       >       >
      >       >       > rh CNR = 1.448
      >       >       >
      >       >       >  total CNR = 1.446
      >       >       >
      >       >       >
      >       >       > 2) When you add  -label
      >       >     
       $FREESURFER_HOME/subjects/bert/label/lh.cortex.label
      >       >       > 
      $FREESURFER_HOME/subjects/bert/label/rh.cortex.label
      >       to the
      >       >       first command,
      >       >       > you get different (lower) cnr values.
      >       >       >
      >       >       > white = 96.6+-6.0, gray = 73.1+-18.9, csf =
      50.8+-20.5
      >       >       gray/white CNR = 1.38
      >       >       > 9, gray/csf CNR = 0.644
      >       >       >
      >       >       > lh CNR = 1.016
      >       >       >
      >       >       > white = 96.4+-6.0, gray = 73.4+-18.8, csf =
      51.0+-20.3
      >       >       gray/white CNR = 1.35
      >       >       > 3, gray/csf CNR = 0.652
      >       >       >
      >       >       > rh CNR = 1.002
      >       >       >
      >       >       > total CNR = 1.009
      >       >       >
      >       >       > How is the lh.cortex and rh.cortex label
      changing the
      >       CNR
      >       >       computation?
      >       >       >
      >       >       > Any inputs or thoughts on this matter are
      greatly
      >       appreciated!
      >       >       >
      >       >       > Thanks,
      >       >       > Prad
      >       >       >
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