Hi Susanna, 

yes, as you feared, you should rerun the first time point so that all time 
points are run by the same version. Edits should be preserved (although maybe 
more or probably less edits would be necessary). 

And it is really a bad idea to compare across groups where the groups where 
processed with different software methods (here 5.3 an 6.0). You will not know 
if the differences that you find come from the methods or are real. 
Best, Martin


> On 13. Apr 2018, at 10:21, Susanna Carmona Cañabate 
> <susannacarm...@gmail.com> wrote:
> 
> Dear Freesurfers,
> 
> We are running a longitudinal study with 4 time points. The first two time 
> points were processed and edited with the 5.3 version of Freesurfer and the 
> other two time points with FS6. I assume we have to re-run the first two time 
> points with the new versión, but is there a way to preserve the editings?
> 
> In the same line, on a transversal study, would it be a lot of bias if most 
> of the subjects of one group are processed with version 5.3 and most of the 
> subjects of the other group with FS6?
> 
> Thanks a lot for your time
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