Hi Nazanin

1. The registration is only one step in how we do segmentation, so I wouldn't suggest just using it. If you can convert your registration to .m3z format and put it in the subjects transforms/talairach.m3z you could try running from there forward.

2. Yes, you can edit the aseg in freeview.

3. Yes, the segmentations have improved in V6

cheers
Bruce
On Wed, 8 Nov 2017, N Saf wrote:

Hi Bruce
as you explain I did the registration somewhere else and now I have the 
labels_gca in my subject
space.
1. is it possible to somehow import this file in freesurfer and run the rest of 
the analysis ? 
2.my question in general is that : can I in anyway  do any correction for aseg 
outputs during the
analysis(similar to troubleshooting for surface-base analysis) e.g. do some 
step with different
method and then import the result and use the rest steps in freesurfer??
3.Is there any difference between the subcortical segmentation results in v.6  
vs v5.3 (except the
hippopotamus subfields segmentation which is available in v.6 . Is the hole 
hippocampus volume
result  different between 2 versions?) 

I'm really appreciated for the help.

Best Regards,
Nazanin



On Mon, Oct 30, 2017 at 5:36 PM, Bruce Fischl <fis...@nmr.mgh.harvard.edu> 
wrote:
      Hi Nazanin

      the nonlinear registration is actually to our segmentation atlas (*.gca). 
I guess you
      could try using something else, but you should extract a mean intensity 
image from the
      gca as a target, not the MNI305. You can do this with:

      mri_convert -nth 0 <file>.gca mean_gca.mgz

      FYI, this:

      mri_convert -nth 1 <file>.gca labels_gca.mgz

      would give you the highest prior label at each spot (and 2 would give you 
the prior)

      cheers
      Bruce



      On Mon, 30 Oct 2017, N Saf wrote:

            Dear Experts,
            In the volume-based stream, if I'm right the FreeSurfer does two
            registration with MNI305 ,one affine and one
            nonlinear , is it possible to perform the nonlinear registration 
somewhere
            else and then use the result in
            FreeSurfer and run the rest of the analysis ? 

            thank's alot for your great support.

            BRG,
            Nazanin



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