Hi Doug, I am referring to a rather old thread where you have provided some interesting suggestions to perform group-wise analysis of WMHs. I am trying to do something similar in patients and controls. First, mri_binarize was used to extract the individual WMH volumes from aseg.mgz. These volumes were subsequently warped into MNI305 space and smoothed (using mri_fwhm 8mm). The goal is to compare the spatial distributions of WMH between both groups. Finally, mri_concat --mean was used to visualise group averaged WMH volumes. The outputs can be found here: http://imgur.com/a/curYf
Do these steps look alright? On a conceptual level, is it statistically valid to compare stacks of binarised lesion maps between groups (using mri_glmfit and then performing MC with FDR/mri_glmfit-sim)? On an individual level, I noticed that some WMH voxels show up inside the MNI305 ventricles for a few subjects. This happens despite a good-looking talairach registration. Thanks a lot for your time in advance and I’ll appreciate any thoughts you may have on this. Sincerely, Elijah Dr. Elijah Mak, Research Associate Department of Psychiatry, Old Age Psychiatry Group University of Cambridge Trinity College, CB21TQ, UK http://www.neuroscience.cam.ac.uk/directory/profile.php?fkm24
_______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
