For the interaction it would be

0.5 -0.5 -0.5 0.5


On 5/9/17 8:32 AM, Laura Ferrero Montes wrote:
>
>    Thank you for the information. I just want to be sure if I have
> understood it properly.
>    If I had two groups and two sites, my design matrix would be like:
>
> GroupDescriptorFile 1
> Class PatientsGroup1
> Class PatientsGroup2
> Class ControlsGroup1
> Class ControlsGroup2
>
>    If I want to test for the effect of group, contrast matrix would be:
>    0.5 -0.5 0.5 -0.5
>
>    If I want to test for the effect of site, contrast matrix would be:
>    0.5 0.5 -0.5 -0.5
>
>    Finally, in case of interaction test, how contrast matrix would be?
>
>
>
>
>
> Douglas N Greve <gr...@nmr.mgh.harvard.edu> escribió:
>
>> You should make sure to have a balanced design (ie, approx the same pats
>> and cons at each site). Then include site as a regressor, ie, if you had
>> two groups and two sites, you would have four regressors.  You could
>> then test for the effect of group, the effect of site, and the
>> interaction. If there is an interaction, then it is hard to interpret
>> the differences between groups.
>>
>
>
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