Thanks Bruce!

That’s really good to know. So therefore, no need to have a “compromise” set of 
echo images for dura correction if I’m not feeding both inputs to recon-all? 
Would it make sense to run both days separately and just average thickness 
values between ROIs to reach a single value for each subject?

I guess this question is slightly complicated by having functional data on both 
days as well. I was debating which structural scan (post-freesurfer) to use as 
my registration base for the functional data. It seems I have two options: use 
the scan collected the same day as the functional — or use a single structural 
for both days (hence the impulse to feed both scans to a single recon-all.

I suppose a third option is just pick the scan with best quality and go with 
that for everything.

Do you have a gut feeling on which is the better strategy?

Best,
Jared


> Hi Jared
> 
> it's really an empirical question. With high quality data we have found 
> that adding scans doesn't help CNR very much (it reduced the N but the 
> blurring induced by differential distortion also reduces the C). If your 
> scans are noisy it might be worth it, but it really depends on the 
> acquisition
> 
> cheers
> Bruce
> 
> 
> On Fri, 28 Apr 2017, Jared 
> Saletin wrote:
> 
> > Hi Freesurfer Experts!
> >
> > I have two scans for each subject in a new experiment—taken on subsequent 
> > days, each using the MEMPRAGE protocol.
> >
> > I’ve successfully implemented DURA correction using the 4 echos when I’ve 
> > reconstructed each scan separately.
> >
> > However, since I have 2 scans for each subject, I was thinking rather than 
> > reconstruct the brain twice and average the thickness measurements, it 
> > would be better to feed both MEMPRAGE scans to recon-all.
> >
> > My question is if I do this, which echos should I use for Dura correction: 
> > day 1 or day 2 or is there a way to combine them into an average?
> >
> > Is this (feeding both days’ scans to recon-all) a reasonable strategy, or 
> > am I better to reconstruct the data separately?
> >
> > Thanks so much!
> > Jared
> > _______________________________________________
> > Freesurfer mailing list
> > Freesurfer at nmr.mgh.harvard.edu 
> > <https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer>
> > https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer 
> > <https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer>
> >


—

Jared M. Saletin, PhD

Assistant Professor of Psychiatry and Human Behavior
Alpert Medical School of Brown University

E.P. Bradley Sleep Research Lab
300 Duncan Drive
Providence, RI 02906

Email: jared_sale...@brown.edu
Phone: 401-421-9440 
Fax: 401-453-3578



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