Dear Martin,

thanks for the feedback. We had to edit cross due to the fact that

1. our dataset is involved also in cross-sectional studies
2. we are continuously acquiring timepoints but want to do some analyses with 
data we already have

Therefore only editing the base was not an option for us.

I was thinking (to save time spent on edits) of transferring the INTERSECTION 
of wm edits from all cross points to base. 
I think this should work, the only issue I see here is how to handle resampling 
from space of cross to the space of base. What do you think?

And, regarding the v6.0 is currently released, would you recommend to 
re-process our cross-sectional data (originally processed with v5.3) with v6.0?
Would you expect any issues with cross-sectional edits made on v 5.3? Most of 
the edits are on the wm.mgz, some on brainmask.mgz or 
brain.finalsurfs.manedit.mgz.

Regards,

Antonin





Hi Antonin, 

in most cases it should be sufficient to only edit wm.mgz in the base, instead 
of editing all time points. This is a big time saving especially if you have 
many time points.I don’t think merging edits from cross will work well, as 
there could be 
atrophy and lots of non-linear deformations in some of the fast progressing 
brains. 

Best, Martin

> On 23 Jan 2017, at 23:11, Antonin Skoch <a...@ikem.cz> wrote:
> 
> Dear experts,
> 
> I am currently starting longitudinal analysis of data I previously corrected 
> in cross-sectional stream (FreeSurfer v5.3).
> The analysis comprises quite large number of subjects - approx 150 subjects, 
> each scanned twice.
> All subjects are already inspected and errors corrected in cross-sectional 
> analysis. Some of them needed quite large edits, mainly to the wm.mgz and the 
> whole process took large time.
> 
> As I read the documentation, the wm.mgz edits in cross are not currently 
> transferred to base. However, wm.mgz has to be correct in base in order to 
> estimate surfaces correctly. From this it implies to me that I would need to 
> edit all wm.mgz errors in base again.
> Do you think that it could be possible/reasonable to transfer some wm.mgz 
> edits from cross to base, for example to make intersection of edits of all 
> cross timepoints and to transfer it to the base? This could significantly 
> reduce time spent on edits. Does it make sense? 
> 
> Regards,
> 
> Antonin Skoch 
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