not sure what you are testing, but if you are, eg, looking at the 
difference between two groups regressing out ICV, then it can make a 
huge difference


On 08/29/2016 12:36 PM, Corinna Bauer wrote:
> Hello all,
>
> I am wondering why results would change completely for between group 
> volume analysis when using demeaned/mean-centered ICV compared to 
> using ICV as a covariate in mri_glmfit? See the figures below.
>
> Does demeaning the covariate inherently change the results comapred to 
> the raw covariate values?
>
> Thanks
>
> Corinna
>
>
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