Hi,

I want to compare two populations using CVS so I can cross-register multimodal 
maps (e.g. ASL, FA, QSM) for volumetric comparisons.

I’ve gotten CVS to work very well registering one subject to another, it really 
is impressive

However, using the --mni option, it doesn’t work so well, perhaps because the 
atlas is so averaged together and smoothed out, the images look highly warped.

I know I can pick a subject at random, and register everything to that, but 
that may induce some biases. The following website suggests I might try simply 
creating my own atlas (under the answers to Nov 2014 course questions): 
https://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/QuestionAnswers 
<https://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/QuestionAnswers>

Seems like they register 40 subjects with each other for multiple iterations, 
average the brain together, then run recon-all on that. How does one actually 
do that, however? i.e. 1st round, register everyone to subject 1 … then what? 
Seems like somehow you would want a registration intermediate point somehow?

Any help would be great, thank you!

Michael Zeineh, M.D.-Ph.D.
Assistant Professor, Dept. of Radiology
Stanford University
Lucas Center for Imaging
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