On 06/20/2016 08:25 PM, Pradeep wrote:
> Hello Freesrufer Team,
>
> I am trying to use the Partial volume correction procedure implemented 
> in the freesurfer 6 beta version and have a few questions.
>
> In your recent Neuroimaging paper, the left and right hemispheres were 
> combined by taking the average of the two as they did not show any 
> age-by-hemisphere interaction.
>
> I might have interpreted the Supplementary figure 1 incorrectly, but 
> the Geometric transfer matrix seem to show around 52 ROI's, So were 
> the L and R ROIs combined for the PVC results you reported in  that 
> paper? Or were the same 52 used for the general PVC in the FS pipeline?
They were combined only after the PVC calculation. For the figure, I 
changed the GTM to show the combined GTM.
>
> Do you have any concrete results to examine the effects of the size 
> variation over the ROIs used for PVC?
Not sure what you mean here. You can get the variance reduction factor 
for each ROI in the gtm.stats.dat file. This indicates how much noise 
reduction you can expect (assuming gaussian noise, etc) in each ROI 
given the size and anatomical distribution of the ROIs and PSF.
> Should a threshold be set for the sizes of these ROIs?
What do you mean?
>
> How were the white matter hypo-intensities dealt with while generating 
> the ROI masks?
I merged them with WM. I tried it with and without, and it did not make 
much of a difference.
doug
>
>
> Thanks,
> Pradeep
>
>
>
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-- 
Douglas N. Greve, Ph.D.
MGH-NMR Center
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