Hi Martin,

I am also following this thread with interest. Is that multi-modal
prototype you mentioned available in the next FS6.0?


Many thanks.


Best Wishes,

Elijah


Navena Rebecca Lingum
<http://www.mail-archive.com/search?l=freesurfer@nmr.mgh.harvard.edu&q=from:%22Navena+Rebecca+Lingum%22>
Wed, 18 May 2016 10:25:09 -0700
<http://www.mail-archive.com/search?l=freesurfer@nmr.mgh.harvard.edu&q=date:20160518>

Would any member of the FreeSurfer team be able to help with this question?

I would like to use the FreeSurfer software to delineate white matter
hyperintensities. I have processed my T1 images using the recon-all command,
and in the aseg.stat file there is a value for WM hypointensities.

Is there an alternate stream/ FreeSurfer algorithm that exists for the
processing of T2w FLAIR images for WM hyperintensities?

Thanks,
Navena


________________________________
From: freesurfer-boun...@nmr.mgh.harvard.edu
<freesurfer-boun...@nmr.mgh.harvard.edu> on behalf of Martin Reuter
<mreu...@nmr.mgh.harvard.edu>
Sent: May 17, 2016 1:32 PM
To: Freesurfer support list
Subject: [Freesurfer] WM Hyperintensities

Hi Navena,

I am the wrong person to answer questions about the WM lesion stream. I think
the one that is available in FreeSurfer is only based on T1 images, but a
prototype of a better stream exists, that can incorporate different modalities.

Best, Martin

P.S. Changed the subject, to reflect that this is not a longitudinal question
any more.

On 05/17/2016 12:37 PM, Navena Rebecca Lingum wrote:
Dear Martin,

Thank you kindly for your prompt response.

I am actually having difficulties with the delineation of White Matter
Hyperintensities at a single time point. I apologize if my question is
redundant and perhaps an answer to it is already mentioned elsewhere.

As it stands, I am finding it difficult to understand the exact "pipeline" of
commands necessary to perform this segmentation and accurate delineation of
WMH. I have ran the recon -all command on my T1w images, but I suspect a proper
segmentation of WMH would require a T2w Flair (which I have). How do I go about
combining the preprocessing data produced by FreeSurfer with my T2w images to
produce a WMH mask/volume/stats?

Any help on the matter is much appreciated!

Kindly,
Navena Lingum


On May 16, 2016, at 4:24 PM, Martin Reuter
<mreu...@nmr.mgh.harvard.edu<mailto:mreu...@nmr.mgh.harvard.edu
<mreu...@nmr.mgh.harvard.edu>>> wrote:

Hi Navena,

There is currently no dedicated stream for longitudinal WM abnormalities (in
the sense of joint estimation and modeling). You can, however, make use of the
longitudinal stream and it's increase reliability - e.g it is working in the
same space across time, which should help get more reliable estimates.

Best, Martin

On 05/16/2016 01:47 PM, Navena Rebecca Lingum wrote:
Dear FreeSurfer experts,

My colleagues and I would like to use FreeSurfer to perform a longitudinal
analysis of white matter hyperintensities. Is there an additional add-on for
the software to perform this analysis or can this analysis be performed using
the recon-all command?

Navena Lingum



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--
Martin Reuter, PhD
Assistant Professor of Radiology, Harvard Medical School
Assistant Professor of Neurology, Harvard Medical School
A.A.Martinos Center for Biomedical Imaging
Massachusetts General Hospital
Research Affiliate, CSAIL, MIT
Phone: +1-617-724-5652
Web  : http://reuter.mit.edu

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-- 

Elijah Mak, Gates Scholar

PhD Candidate *|* Psychiatry

University of Cambridge

Trinity College, Cambridge, CB2 1TQ
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