If QDEC gives you that contrast, then it is the same. QDEC is a bit 
clunky when it comes to correctly for multiple comparisons, but it 
should give the same answer as mri_glmfit
doug

On 10/28/2015 04:23 AM, Sandy Schramm wrote:
> Dear Doug,
> thanks for reply.
> But isn't it statistically the same: compare e.g. the thickness 
> of morbid group 1 with the controll group via Qdec respectively 
> compare both groups via contrasts (e.g. 1 0 0 -1) in mri_glmfit?
> For me the only advantage of mri_glmfit is to controll for more 
> variables/covariates. Are there more advantages?
> Kind regards
> Sandy
> *Gesendet:* Dienstag, 27. Oktober 2015 um 16:27 Uhr
> *Von:* "Douglas Greve" <gr...@nmr.mgh.harvard.edu>
> *An:* freesurfer@nmr.mgh.harvard.edu
> *Betreff:* Re: [Freesurfer] comparison of 4 groups: mri_glmfit or Qdec?
> yes, use mri_glmfit
> doug
>
> On 10/26/15 3:34 AM, Sandy Schramm wrote:
> > Dear Experts,
> >
> > we want to compare data (thickness) of 4 groups (3 morbid groups and 1
> > controll group). Both, Qdec and mri_glmfit, will do the same analyses.
> > But we are not sure, if the usage of Qdec is statistically correct in
> > our case. Because in Qdec we can only compare 2 of the 4 groups. But
> > Qdec is much more comfortable to handle.
> > Or do you advise the mri_glmfit for our data analyses?
> >
> > Thanks for some advice!
> > Sandy Schramm
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> >
> >
>
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