Hi Bruce,

Thanks for the reply. The talairach.xfm file generated by the palarellizing
machine is empty; it looks as follows:

Talairach.xfm file:

MNI Transform File

% avi2talxfm



Transform_Type = Linear;

Linear_Transform =


However, the talaraich.xfm file generated by the non-paralellizing machine
is the following:


MNI Transform File

% avi2talxfm



Transform_Type = Linear;

Linear_Transform =

1.088816 -0.036409 -0.059575 1.880753

0.047590 1.030018 0.245325 -4.493217

0.029937 -0.211744 1.231518 94.663368;


Anna

On Thu, Oct 22, 2015 at 6:00 PM, <freesurfer-requ...@nmr.mgh.harvard.edu>
wrote:

> Send Freesurfer mailing list submissions to
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>
> Today's Topics:
>
>    1.  normalization of hippocampal volume (geschwind2013)
>    2. Postdoctoral Opportunity: Multimodal MRI registration     and
>       analysis (Frederic Andersson)
>    3. Re: A mixed effect model approach in within subject dataset
>       {Disarmed} {Disarmed} (jorge luis)
>    4. Re: Sulcal depth units (Bruce Fischl)
>    5. Re: mris_expand - problem reading thickness file? (Bruce Fischl)
>    6. Re: How to compute the measures on the average brain?
>       (Bruce Fischl)
>    7. Re: Talairach_afd error (Bruce Fischl)
>    8. Re: How to compute the measures on the average brain?
>       (Douglas N Greve)
>    9. Re: normalization of hippocampal volume (Douglas N Greve)
>   10. Re: per analysis with covariates (Douglas N Greve)
>
>
> ----------------------------------------------------------------------
>
> Message: 1
> Date: Thu, 22 Oct 2015 17:18:21 +0900
> From: geschwind2013 <neurof...@gmail.com>
> Subject: [Freesurfer]  normalization of hippocampal volume
> To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
> Message-ID: <27af7eca-e1b4-4337-bb2c-4cbe4109f...@gmail.com>
> Content-Type: text/plain; charset=euc-kr
>
> Hi, FS Experts,
>
> I?m using version 5.3 and have performed hippo-subfields analysis.
>
> To perform the statistics, shall I get the normalized volumes of each
> hippo-subfields?
> or just to do correction for ICV is enough ?
>
> thanks..
>
> Hyon
>
>
> ------------------------------
>
> Message: 2
> Date: Thu, 22 Oct 2015 15:30:14 +0200
> From: Frederic Andersson <anders...@univ-tours.fr>
> Subject: [Freesurfer] Postdoctoral Opportunity: Multimodal MRI
>         registration    and analysis
> To: freesurfer@nmr.mgh.harvard.edu
> Message-ID: <6e3a85f5-c942-49d0-bbe0-4c51c4e8e...@univ-tours.fr>
> Content-Type: text/plain; charset="utf-8"
>
> Postdoctoral Opportunity: Multimodal MRI registration and analysis
>
> Context and methodology
> This postdoctoral position will focus on the registration of ex-vivo onto
> in-vivo MR data. Based on some recent advances extending the combined
> volume and surface registration, efficient approaches can be provided for
> dealing with this issue. However, these methods need to be validated and
> several open theoretical questions are related to this problem and will be
> investigated during this postdoctoral work. The theoretical results
> obtained will be tested and used on real human data in a larger framework
> aiming at tractography validation (French National Research Agency Grant
> ANR 2014, collaborative study Inserm U930, Universit? de Tours, Neurospin
> and Martinos Center).
>
> Applicant profile
> Candidates should have a strong background in image registration and MR
> imaging, a good publication record, and strong experience in c++ and matlab
> coding. Proficiency in English is required, as well as scientific writing
> skills.
> Applicants should send a CV, including list of publications and a
> description of previous research experience, as well as the names and
> emails of two academic referees to: Clovis Tauber (
> clovis.tau...@univ-tours.fr <mailto:clovis.tau...@univ-tours.fr>) and
> Christophe Destrieux (christophe.destri...@univtours.fr <mailto:
> christophe.destri...@univtours.fr> )
>
> Conditions
> Starting date: January 2016 (adjustable)
> Contract: 2 years
> Location: Imaging and Brain unit, INSERM U930, Tours.
> Salary: related to experience
>
> References
> G.M. Postelnicu, L. Z?llei, B. Fischl: Combined Volumetric and Surface
> Registration, IEEE Transactions on Medical Imaging 28 (4), April 2009, p.
> 508--522
> Zemmoura I, Serres B, Andersson F, Barrantin L, Tauber C, Filipiak I,
> Cottier JP, Venturini G and Destrieux C 2014 FIBRASCAN: a novel method for
> 3D white matter tract reconstruction in MR space from cadaveric dissection
> Neuroimage 103 106?118
> Serres B, Zemmoura I, Andersson F, Tauber C, Destrieux C and Venturini G
> 2013 Brain Virtual Dissection and White Matter 3D Visualization Stud.
> Health Technol. Inform. 184 392--396
> -------------- next part --------------
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> ------------------------------
>
> Message: 3
> Date: Thu, 22 Oct 2015 13:45:28 +0000 (UTC)
> From: jorge luis <jbernal0...@yahoo.es>
> Subject: Re: [Freesurfer] A mixed effect model approach in within
>         subject dataset {Disarmed} {Disarmed}
> To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
> Cc: "pablon...@hotmail.com" <pablon...@hotmail.com>
> Message-ID:
>         <1841220171.2266406.1445521528699.javamail.ya...@mail.yahoo.com>
> Content-Type: text/plain; charset="utf-8"
>
> Hi Pablo
>
> If you havethoroughly checked that everything is properly setup so that
> theordering of the design matrix's rows is in proper correspondence withthe
> ordering of the image data matrix's rows and it is also in
> propercorrespondence with the ordering of the entries in vector ni
> (eachentry of this vector has the number of subjects belonging to the
> samefamily) and the design matrix has enough covariates to describe
> yourdata then the analysis should be correct.
>
> Bear in mind thatyou are not analyzing longitudinal data for which a
> proper imageregistration pipeline exists in Freesurfer and there is a
> clearwithin-subject correlation between cortical thickness values
> acrosstime points at the same surface vertex. Instead you are
> analyzingfamily data in which you are trying to model vertex-wise
> correlationsacross different subjects. Although in principle there should
> bewithin-family correlation the image registration procedure (and
> imageprocessing pipeline in general) as well as individual variation
> couldhave introduced a lot of noise in your data making the
> vertex-wisewithin-family correlations rather weak. This makes it hard for
> theLME estimation procedure to converge and give precise parameterestimates.
>
> Best-Jorge
>
>
>
>       De: pablo najt <pablon...@hotmail.com>
>  Para: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
>  Enviado: Jueves 22 de octubre de 2015 1:15
>  Asunto: Re: [Freesurfer] A mixed effect model approach in within subject
> dataset {Disarmed} {Disarmed}
>
> <!--#yiv0632092676 .yiv0632092676hmmessage
> P{margin:0px;padding:0px;}#yiv0632092676
> body.yiv0632092676hmmessage{font-size:12pt;font-family:Calibri;}-->Hello
> again,I have now also run the model with 2 random effects and it is
> definitively worst. The final line says:Algorithm did not converge at
> 79.5859 percent of the total number of locations.
> Any suggestion if I should trust in the model with 1 random effect? I know
> you Martin had doubts, so I am wondering what Jorge thinks of it.ThanksPablo
>
> To: freesurfer@nmr.mgh.harvard.edu
> From: mreu...@nmr.mgh.harvard.edu
> Date: Wed, 21 Oct 2015 08:55:04 -0400
> Subject: Re: [Freesurfer] A mixed effect model approach in within subject
> dataset {Disarmed} {Disarmed}
>
>  Hi Pablo,
>
>  23% still seems a lot, but may be OK (maybe Jorge can comment on that)?
>
>  If you want to do a model comparison (2 random vs 1) take a look at the
> wiki. It describes how to do that.
>
>  Best, Martin
>
>  On 10/21/2015 01:19 AM, pablo najt wrote:
>
>  <!--#yiv0632092676 .yiv0632092676ExternalClass .yiv0632092676ecxhmmessage
> P {padding:0px;}#yiv0632092676 .yiv0632092676ExternalClass
> body.yiv0632092676ecxhmmessage {font-size:12pt;font-family:Calibri;}-->
> Martin, Doing the changes in the matrix allowed me to run the command. The
> command with just one random effect for the intercept term give me the
> following output:
>  Aproximate percentage of fitted locations: 100%  Summary:   Algorithm did
> not converge at 23.407 percent of the total number of locations.   Total
> elapsed time is 116.2184 minutes.
>
>   Is this ok? Is there anything I should check? Should I also try two
> random effects as well? Thank you Pablo
>   To: freesurfer@nmr.mgh.harvard.edu
>  From: mreu...@nmr.mgh.harvard.edu
>  Date: Tue, 20 Oct 2015 09:06:53 -0400
>  Subject: Re: [Freesurfer] A mixed effect model approach in within subject
> dataset {Disarmed} {Disarmed}
>
>  Hi Pablo,
>
>  the zero columns could be outside the cortex and then this would be fine.
> Do
>  min(sum(lhY(:,lhcortex)))
>  if you get 0 you have at least one location where the column is all zero
> (as we should not have any negative values, you can test that with
> min(lhY(:))
>  Now even if you still have a column of 0 , then that vertex is
> problematic, but who cares about a single vertex. If you do a region
> approach, it will be part of a region anyway. so you should check how often
> you get 0 columns (inside cortex).
>
>  About your M: I would subtract 1 from gender (to have 0 and 1)
>  Also you only need 2 columns for the groups: keep only column 3 and 4. A
> HC is someone who has 0 in both.
>
>  Best, Martin
>
>
>
>  On 10/20/2015 04:37 AM, pablo najt wrote:
>
>  <!--#yiv0632092676 .yiv0632092676ExternalClass .yiv0632092676ecxhmmessage
> P {padding:0px;}#yiv0632092676 .yiv0632092676ExternalClass
> body.yiv0632092676ecxhmmessage {font-size:12pt;font-family:Calibri;}-->
> Dear ?FS experts, I am following up on an issue I am having when trying to
> run linear mixed effects model. I keep getting 'Algorithm did not
> converge'. So far I have changed the preprocessing steps following
> literally from the wiki as in message below. Also I tried to use only one
> random effect for the intercept. Also I have checked that?sum of vectors of
> (ni) is equal to the number of rows in (X).
>   As none of the above worked I started to have concerns about the
> dimensions of my lh.thickness_sm10.mgh. ?When I load in matlab in working
> space says 'too many variables'. Is this ok?   ?  ?
>
>   Also, when I open 'lhY' variable it shows a column of Zeros every nine
> columns as below. Is this alright?
>     ?  ?
>
>   Perhaps this is fine but I would like to check on anything that is
> creating this problem. For matrix 'M' I created a matlab script that loads
> a matrix with intercept (all ones), HC (ones to HC otherwise zero), U_PT
> (relatives of patients ones otherwise zero), PT (patients one otherwise
> zero), gender, age (see below). The three columns for groups do not
> match?the qdec.table.dat which have only one column for groups (HC, U_PT,
> PT). However the?order of the rows is identical in M and qdec.table.dat
>  ?  ?
>
>   ?Please let me know if this should be set differently. Thank you Pablo
>
>
>   To: freesurfer@nmr.mgh.harvard.edu
>  From: mreu...@nmr.mgh.harvard.edu
>  Date: Mon, 19 Oct 2015 09:00:57 -0400
>  Subject: Re: [Freesurfer] A mixed effect model approach in within subject
> dataset {Disarmed}
>
>  Hi Pablo,
>
>  since you did not run this through the longitudinal stream, you won't
> have a base ( or subject-template), also you won't have <tpid>.long.<base>
> directories, so the first command should fail. For that you simply replace
> the --qdec-long with --qdec and use the same  table. Should work. The
> second command is fine (it just smoothes the thickness stack).
>
>  Best, Martin
>
>  On 10/19/2015 06:51 AM, pablo najt wrote:
>
>  <!--#yiv0632092676 .yiv0632092676ExternalClass .yiv0632092676ecxhmmessage
> P {padding:0px;}#yiv0632092676 .yiv0632092676ExternalClass
> body.yiv0632092676ecxhmmessage {font-size:12pt;font-family:Calibri;}--> Hi
> Jorge and FS experts, I have run again the analysis and still get the
> convergence problem. I am assuming the issue has to do with the
> preprocessing steps, as I had doubts on how to follow from the instructions
> if I am not using qdec and have a cross sectional design.
>   Instructions on lme in the wiki for preprocessing specify the following:
>    mris_preproc --qdec-long qdec.table.dat --target study_average --hemi
> lh --meas thickness --out lh.thickness.mgh  mri_surf2surf --hemi lh --s
> study_average --sval lh.thickness.mgh --tval lh.thickness_sm10.mgh
> --fwhm-trg 10 --cortex  --noreshape  My data -as I explained below- is
> cross section but I want to treat it as longitudinal as I want to analyse
> subjects  belonging to the same family.? Here is my 2 main questions:? 1)
> for preprocessing should I follow instructions as it would be longitudinal
> data? 2) Although my design does not allow using qdec (3 groups) do I still
> create a qdec table and follow literally the two  instructions above ?
> Thank you Pablo
>
> ____________________________________________________________________________________________________________________________________
>
>   Date: Fri, 16 Oct 2015 16:24:36 +0000
>  From: jbernal0...@yahoo.es
>  To: freesurfer@nmr.mgh.harvard.edu
>  CC: pablon...@hotmail.com
>  Subject: Re: [Freesurfer] A mixed effect model approach in within subject
> dataset {Disarmed}
>
>   Hi Pablo
>   Yes, too many locations at which the estimation algorithm didn't
> converge is problematic. That might mean  that having two random effects is
> not appropriate for your data. You should try to run the command with just
> a single random effect for the intercept term:
>   lhstats = lme_mass_fit_vw(X, [1], lhY, ni, lhcortex, [], 4);
>   If the result still have too many non-convergence locations then
> something might be wrong with the  ordering of the design matrix and its
> correspondence with the ordering of the ni vector or the ordering of the
> image data etc... You will need to check it thoroughly.
>   Cheers -Jorge
>
>
>
>
>
>
>       De: pablo najt <pablon...@hotmail.com>
>  Para: "freesurfer@nmr.mgh.harvard.edu" <freesurfer@nmr.mgh.harvard.edu>
>  Enviado: Viernes 16 de octubre de 2015 1:43
>  Asunto: Re: [Freesurfer] A mixed effect model approach in within subject
> dataset {Disarmed}
>
>   <!--#yiv0632092676 .yiv0632092676ExternalClass
> #yiv0632092676ecxyiv7275178360 body.yiv0632092676ecxyiv7275178360hmmessage
> {font-size:12pt;font-family:Calibri;}-->  Thanks you for the replies. Jorge
> and FS experts, I have run the analysis and first double checked that the
> sum of vectors of  (ni) is equal to the number of rows in (X). Both are 140
> which is the number of my subjects. The analysis gave the following
> 'error'(?) below: I looked up a previous thread coming across this. At that
> case you  recommended Would you recommend this afain>
>
>   Aproximate percentage of fitted locations: 100%   Warning: matlabpool
> will be removed in a future  release.   To query the size of an already
> started parallel pool, query the  'NumWorkers'   property of the pool.   To
> check if a pool is already started use  'isempty(gcp('nocreate'))'.?
>  Warning: matlabpool will be removed in a future  release.   To shutdown a
> parallel pool use 'delete(gcp('nocreate'))'  instead.?   Parallel pool
> using the 'local' profile is shutting  down.   ??   Summary:   Algorithm
> did not converge at 90.0637 percent of  the total number of locations.
>  Total elapsed time is 550.1023 minutes.
>
>   Also almost all the time the screen showed the  following message:
>    144114: Algorithm did not converge. Initial  and final likelihoods:
> -38.3408-1.5708i,-241.4153-1.570796i.     Location 144113: Algorithm did
> not converge.  Initial and final likelihoods: -5.5424-1.5708i,
> -133.8004-1.570796i.     Location 144112: Algorithm did not converge.
> Initial and final likelihoods: -7.7571-1.5708i, -319.1378-1.570796i.
>  Location 144111: Algorithm did not converge.  Initial and final
> likelihoods: -16.8597-1.5708i, 0.74448.     Aproximate percentage of fitted
> locations:  100%
>
>   So my two questions are: 1. Is this problematic? 2. Are there any fixes
> to this issue? Thank you, Pablo
>   Date: Thu, 15 Oct 2015 13:38:22 +0000
>  From: jbernal0...@yahoo.es
>  To: freesurfer@nmr.mgh.harvard.edu
>  CC: pablon...@hotmail.com
>  Subject: Re: [Freesurfer] A mixed effect model approach in within subject
> dataset {Disarmed}
>
>
>
>     Hi Pablo
>   The error you are getting is because  in your Matlab setup you can only
> request a maximum of 4 matlab parallel workers  and by default lme requests
> 8. So you just need to  modify your command like this:
>   lhstats = lme_mass_fit_vw(X,  [1 2], lhY, ni, lhcortex, [], 4);
>   Please make sure that sum(ni) and  length(X) give the same value before
> running the above command.
>   Cheers -Jorge
>
>
>
>       De: pablo najt <pablon...@hotmail.com>
>  Para: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
>  Enviado: Jueves 15 de octubre de  2015 7:18
>  Asunto: Re: [Freesurfer] A  mixed effect model approach in within
> subject dataset {Disarmed}
>
>   <!---->  Thank you Martin. I am trying to run the  following command
> line and get the  error below. Would you have  a suggestion to overcome
> this issue? Just in case I am also including  a snapshot of my loaded
> variables at the bottom. Many thanks, Pablo >> lhstats =
> lme_mass_fit_vw(X,  [1 2], lhY, ni, lhcortex);
>
>
>   Warning: matlabpool will be  removed in a future release.
>
>   To query the size of an already  started parallel pool, query the
> 'NumWorkers'
>
>   property of the pool.
>
>   To check if a pool is  already started use 'isempty(gcp('nocreate'))'.?
>
>   Warning: matlabpool will be  removed in a future release.
>
>   To query the size of an already  started parallel pool, query the
> 'NumWorkers'
>
>   property of the pool.
>
>   To check if a pool is  already started use 'isempty(gcp('nocreate'))'.?
>
>   Warning: matlabpool will be  removed in a future release.
>
>   Use parpool instead.?
>
>   Starting matlabpool using the  'local' profile ...?
>
>   Error using matlabpool  (line 148)
>
>   Failed to start a parallel pool.  (For information in addition to  the
> causing error,
>
>   validate the profile 'local' in the  Cluster Profile Manager.)
>
>
>
>
>   Error in lme_mass_fit  (line 128)
>
>   ? ? ? ? matlabpool(prs);
>
>
>
>
>   Error in lme_mass_fit_vw  (line 73)
>
>   [stats1,st1] = lme_mass_fit(X,[],Xrows,Zcols,Y,ni,prs,e);
>
>
>
>
>   Caused by:
>
>   ? ? Error using parallel.internal.pool.InteractiveClient/start  (line
> 330)
>
>   ? ? Failed to start pool.
>
>   ? ? ? ? Error using parallel.Job/submit (line 304)
>
>   ? ? ? ? You requested a minimum of 8  workers, but the cluster "local"
> has  the
>
>   ? ? ? ? NumWorkers property set to allow a  maximum of 4 workers. To run
> a
>
>   ? ? ? ? communicating job on more  workers than this (up to a maximum of
> 512 for the
>
>   ? ? ? ? Local cluster), increase the  value of the NumWorkers property
> for  the
>
>   ? ? ? ? cluster. The default value of NumWorkers  for a Local cluster is
> the number of
>
>   ? ? ? ? cores on the local machine.
>
>   ?    ???
>
>
>    To: freesurfer@nmr.mgh.harvard.edu
>  From: mreu...@nmr.mgh.harvard.edu
>  Date: Wed, 14 Oct 2015  10:54:41 -0400
>  Subject: Re: [Freesurfer] A  mixed effect model approach in within
> subject dataset  {Disarmed}
>
>  Hi Pablo,
>
> you should run something like this to get the ni:
>
> [M,Y,ni] = sortData(M,1,Y,sID);  # (sorts the data) see
>  https://surfer.nmr.mgh.harvard.edu/fswiki/LinearMixedEffectsModels
>
>  hope that helps, Martin
>
>
>  On 10/14/2015 10:43 AM,  pablo najt wrote:
>
>   <!----> Dear FS experts. I have query about a relating to a  previous
> email (below).?I am aiming to run a LME analysis on cross-sectional data
> from different families and  have variable 'family' (number of  families)
> as my NI vector.? My design has three groups and  therefore I am not able
> to use qdec. I am running the matlab  commands below and finding some
> difficulty would really  appreciate if you could help out. Thanks Pablo
>   Start analysis as follows:
>   1-Read your label eg.:
>  lhcortex =
> fs_read_label('freesurfer/subjects/fsaverage/label/lh.cortex.label');
>  2-Read the data file eg.:
>  [lhY, lhmri] = fs_read_Y('lh.thickness.mgh');?
>
>   %---------------------I input the concatenated .mgh image from preproc
> and
> mris_surf2surf-----------------------------------------------------------------------%
>
>  3-Fit a vertex-wise lme model with random effects.:
>  lhstats = lme_mass_fit_vw(X, [1 2], lhY, ni, lhcortex);
>
>  Here I am getting the following problems: %-------------------- If I use
> number of families as my ni get the
> following------------------------------------------------------------------------------------------------%
>
>
>
>  lhstats = lme_mass_fit_vw(X, [1 2], lhY, 82, lhcortex);
>
>
>
>  Error using lme_mass_fit (line 108)
>
>
>
>  The total number of measurements, indicated by sum(ni), mustbe the same
> as the number of rows of the design
>
>
>
>  matrix X
>
>
>
>
>
>
>
>
>  Error in lme_mass_fit_vw (line 73)
>
>
>
>  [stats1,st1] = lme_mass_fit(X,[],Xrows,Zcols,Y,ni,prs,e);
>
>
>
>
>   My matrix is organised in "family", "group", Sex" and "age" columns".
>   ?  ?
>  4-Perform vertex-wise inference eg.: CM.C = [your contrast matrix];
> F_lhstats = lme_mass_F(lhstats, CM); 5-Save results eg.:?
> fs_write_fstats(F_lhstats, lhmri,' sig.mgh', 'sig');??
>
>    Date: Thu, 10 Sep 2015 13:44:36  +0000 From: jbernal0...@yahoo.es To:
> freesurfer@nmr.mgh.harvard.edu Subject: Re: [Freesurfer] A  mixed effect
> model approach in within  subject dataset   Hi Pablo   I think you can use
> LME to analyze your data by ordering the rows of your design matrix
> appropriately. You can consider all  subjects belonging to  the same family
> as if they were a  single subject in a longitudinal analysis. You can put
> in  your design matrix all subjects  belonging to family1 first,  then all
> subjects belonging to  family 2 and so on. Then the 'ni' required by
> lme_mass_fit_vw  is a vector with the number of  subjects in each family
> as  its entries (ordered according to  your design matrix). So  the length
> of the 'ni' vector is  equal to the number of different families in your
> data.    Now you can go further and additionally order the rows of your
> design matrix within each family by  age. This will allow you to test the
> effect of age within family.     When choosing the random effects for your
> statistical model remember that a random effect can  only be the intercept
> term or any  covariate that varies within  family. For example you can
> compare a  model with a single random  effect for the intercept term
> against the  same model but considering  both the intercept term and age
> as  random effects.   Hope that helps   Cheers -Jorge
>       De: pablo najt <pablon...@hotmail.com> Para: "
> freesurfer@nmr.mgh.harvard.edu" <freesurfer@nmr.mgh.harvard.edu> Enviado:
> Jueves 10 de septiembre de  2015 8:07 Asunto: [Freesurfer] A mixed effect
> model approach in within  subject dataset       <!----> Dear Freesurfer
> users, I wanted to enquire if  anyone had successfully been able to
> implement Bernal's  Linear Mixed Effects (LME) Models in  cross-section
> dataset *not longitudinal* (please see previous  thread below). ?I am
> willing to perform a LME  (3 groups (HC, PT and Unaffected_relatives) and 3
> covariates  (sex, age, and family) with "family"  variable been a
> within-subject factor. LME?will allow?to control for the  non-independence
> of data contributed by  patients and relatives from  the same families.
> Thanks in advance! Pablo   From: michaelnot...@hotmail.com To:
> freesurfer@nmr.mgh.harvard.edu Date: Wed, 19 Feb 2014  13:10:09 +0100
> Subject: [Freesurfer]  Analysis of structural  data acquired from multiple
> sites by using  a mixed effect model approach   <!----> Hi everybody, I
> want to  compare the surface data of 3 groups  (GroupA, GroupB and
> Controlls) but have the problem that  they were acquired from 4 different
> scanner sites. As I can see  it, there are three ways how I could tackle
> this problem: 1. I could use  mri_glmfit and create a qdec table /
> fsgd-file with 12 classes:  Class GroupA_site1; Class  GroupA_site2,... And
> then use  the contrasts [0.25 0.25 0.25 0.25 0 0  0 0 -0.25 -0.25 -0.25
> -0.25] to compare GroupA to the  Controlls. My Problem with this approach
> is, that the sites don't  contribute the same amount of subjects to the
> analysis. I'm not sure  if this could be handled by simply using a weighted
> contrast.  Meaning, if Site1 and Site2 had  twice as many subjects than
> Site3 and Site4, I could modify the  contrast to [0.33 0.33 0.17 0.17 0 0 0
> 0 -0.33 -0.33 -0.17  -0.17]. 2. I could create dummy  variables to account
> for  the variability between sites.  In this case, I only need to  specify
> 3 classes (Class GroupA; Class  Gro!
>  upB; Cla
> ss Controlls) in  my fsgd-file. And I use a design matrix  that has 4
> dummy variables at the end, which specify to  which site a subject belongs.
> This  approach might work, but I'm  not confident that it is the right one.
> 3.  I could use a mixed effect  model approach and specify site as a
> random effect. If I  understand it correctly, the mixed effect  model
> approach would be the  best one, as it accounts for the  variability within
> sites. Is that correct or are there other  issues/better approaches? I
> tried to  implement a mixed effect  model by using Bernal's Linear Mixed
> Effects (LME) Models (
> http://surfer.nmr.mgh.harvard.edu/fswiki/LinearMixedEffectsModels) but
> run into some problems.  I'm not sure if LME can only be  applied on
> longitudinal  data or if my implementation is wrong. I  have a design
> matrix X that  specifies the characteristics of each  subject per row as
> follows: Intercept?? GroupA?? GroupB?? Controll?? Age?? IQ?? Site1??
> Site2?? Site3?? Site4 1? 1? 0? 0? 11.1? 99?? 0 0 1 0 1? 0? 1? 0? 11.1? 101?
> 0 0 1 0 1? 1? 0? 0? 11.4? 95?? 1 0 0 0 1? 0? 0? 1? 12.4? 100? 1 0 0 0 ...
> As I have no  repeated measures, 'ni' is just a  vector with length X
> containing '1's. If I do now the  vertex-wise linear mixed-effects
> estimation, I get the  following output: >> stats = lme_mass_fit_vw(X,[7  8
> 9 10],Y,ni,lhcortex); Starting  matlabpool using the  'local' profile ...
> connected to 8  workers. ? Starting model fitting at  each location ... ?
> Location 24994: Index exceeds matrix  dimensions. Location 24994:
> Algorithm did not converge.  Initial and final likelihoods:  -10000000000,
> -10000000000.  Location 62484: Index exceeds matrix  dimensions. Location
> 62484: Algorithm did not converge.  Initial and final likelihoods:
> -10000000000, -10000000000.  ... I've checked the matrix  dimensions of X,
> Y, ni and lhcortex and compared them to the LME  mass_univariate example
> stored in ADNI_Long_50sMCI_vs_50cMCI.mat but couldn't  find any divergence.
> Has anybody encountered similar  problems? Is my approach of s!
>  pecifyin
> g  'ni' as a vector of'1's  even legitimate? Thanks,  Michael
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>  --
> Martin Reuter, PhD
> Assistant Professor of Radiology, Harvard Medical School
> Assistant Professor of Neurology, Harvard Medical School
> A.A.Martinos Center for Biomedical Imaging
> Massachusetts General Hospital
> Research Affiliate, CSAIL, MIT
> Phone: +1-617-724-5652
> Web  : http://reuter.mit.edu
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> information in  this e-mail is intended only for the person  to whom it is
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> e-mail  contains patient information,  please contact the Partners
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> information in this e-mail is intended only for the person to whom it is
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>
>  --
> Martin Reuter, PhD
> Assistant Professor of Radiology, Harvard Medical School
> Assistant Professor of Neurology, Harvard Medical School
> A.A.Martinos Center for Biomedical Imaging
> Massachusetts General Hospital
> Research Affiliate, CSAIL, MIT
> Phone: +1-617-724-5652
> Web  : http://reuter.mit.edu
>  _______________________________________________ Freesurfer mailing list
> Freesurfer@nmr.mgh.harvard.edu
> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer The
> information in this e-mail is intended only for the person to whom it is
> addressed. If you believe this e-mail was sent to you in error and the
> e-mail contains patient information, please contact the Partners Compliance
> HelpLine at http://www.partners.org/complianceline . If the e-mail was
> sent to you in error but does not contain patient information, please
> contact the sender and properly dispose of the e-mail.
>
>  _______________________________________________
> Freesurfer mailing list
> Freesurfer@nmr.mgh.harvard.edu
> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
>
>  --
> Martin Reuter, PhD
> Assistant Professor of Radiology, Harvard Medical School
> Assistant Professor of Neurology, Harvard Medical School
> A.A.Martinos Center for Biomedical Imaging
> Massachusetts General Hospital
> Research Affiliate, CSAIL, MIT
> Phone: +1-617-724-5652
> Web  : http://reuter.mit.edu
>  _______________________________________________ Freesurfer mailing list
> Freesurfer@nmr.mgh.harvard.edu
> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer The
> information in this e-mail is intended only for the person to whom it is
> addressed. If you believe this e-mail was sent to you in  error and the
> e-mail contains patient information, please contact the Partners Compliance
> HelpLine at http://www.partners.org/complianceline . If the e-mail was
> sent to you in error but does not contain patient information, please
> contact the sender and properly dispose of the e-mail.
>
>  _______________________________________________
> Freesurfer mailing list
> Freesurfer@nmr.mgh.harvard.edu
> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
>
>  --
> Martin Reuter, PhD
> Assistant Professor of Radiology, Harvard Medical School
> Assistant Professor of Neurology, Harvard Medical School
> A.A.Martinos Center for Biomedical Imaging
> Massachusetts General Hospital
> Research Affiliate, CSAIL, MIT
> Phone: +1-617-724-5652
> Web  : http://reuter.mit.edu
> _______________________________________________Freesurfer mailing
> listfreesur...@nmr.mgh.harvard.eduhttps://
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>
> ------------------------------
>
> Message: 4
> Date: Thu, 22 Oct 2015 10:58:55 -0400 (EDT)
> From: Bruce Fischl <fis...@nmr.mgh.harvard.edu>
> Subject: Re: [Freesurfer] Sulcal depth units
> To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
> Message-ID:
>         <alpine.lrh.2.20.1510221058360.3...@gate.nmr.mgh.harvard.edu>
> Content-Type: text/plain; charset=US-ASCII; format=flowed
>
> Hi Simon
>
> they are originally mm, but I believe we z-score normalize them so that
> the sulc file is 0 mean and unit variance.
>
> cheers
> Bruce
> On Wed, 21 Oct 2015, Simon
> Vandekar wrote:
>
> > Dear Freesurfer experts,
> >
> > I am reading the manuscript "Cortical Surface-Based Analysis II:
> Inflation, Flattening, and a Surface-Based Coordinate System" by Fischl,
> Sereno, and Dale (1999) where the estimation of sulcal depth is described
> on page 199, however from the description I am still unsure of the exact
> units of sulcal depth.
> > Are the units for sulcal depth in mm or are they in arbitrary units?
> >
> > Thanks in advance,
> > Simon
> > _______________________________________________
> > Freesurfer mailing list
> > Freesurfer@nmr.mgh.harvard.edu
> > https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> >
> >
> >
>
>
> ------------------------------
>
> Message: 5
> Date: Thu, 22 Oct 2015 11:05:06 -0400 (EDT)
> From: Bruce Fischl <fis...@nmr.mgh.harvard.edu>
> Subject: Re: [Freesurfer] mris_expand - problem reading thickness
>         file?
> To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
> Message-ID:
>         <alpine.lrh.2.20.1510221104450.3...@gate.nmr.mgh.harvard.edu>
> Content-Type: text/plain; charset="utf-8"
>
> Hi Alex
>
> if you upload the subject that is causing this problem I'll take a look.
> What version are you running and what OS?
>
> cheers
> Bruce
> On Thu, 22 Oct 2015, Alex Puckett
> wrote:
>
> >
> > Hello!
> >
> >
> > I'm having trouble with mris_expand using the -thickness flag.??If I
> expand
> > by a fixed distance instead of % thickness?then mris_expand works no
> problem
> > -??the program seems to be hanging up when?reading the thickness file.
> Has
> > anyone else?experienced?this?
> >
> >
> > The command I'm running (from the surf folder)?is:
> >
> > mris_expand -thickness lh.white 0.5 lh.expandWhiteThick0p5
> >
> > The output from this is:
> > "?using distance as a % of thickness
> > expanding surface lh.white by 50.0% of thickness and writing it to
> > lh.expandWhiteThick0p5
> > reading thickness..."
> >
> > And then...nothing! Watching the CPU usage it appears that resources are
> > used for about 10 -12 minutes and then drops to 0 and just sits there
> for as
> > long as I'll let it (>4 days)?- no error.
> >
> > Also, the thickness files do not appear to be corrupt. I can overlay the
> > thickness data onto a surface no problem.?
> >
> > Any help would be appreciated.
> >
> > Cheers,
> >
> > Alex
> >
> > ---------------------------------------------------------------------
> >
> > FREESURFER_HOME: /usr/local/freesurfer
> >
> > Build stamp: freesurfer-Linux-centos6_x86_64-stable-pub-v5.3.0
> >
> > RedHat release: CentOS Linux release 7.1.1503 (Core)?
> >
> > Kernel info: Linux 3.10.0-229.1.2.el7.x86_64 x86_64
> >
> > ---------------------------------------------------------------------
> >
> >
> >
> >
> >
> >
> >
> >
> >
> > ?
>
> ------------------------------
>
> Message: 6
> Date: Thu, 22 Oct 2015 11:08:04 -0400 (EDT)
> From: Bruce Fischl <fis...@nmr.mgh.harvard.edu>
> Subject: Re: [Freesurfer] How to compute the measures on the average
>         brain?
> To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
> Message-ID:
>         <alpine.lrh.2.20.1510221107490.3...@gate.nmr.mgh.harvard.edu>
> Content-Type: text/plain; charset="windows-1252"
>
> Hi Mathieu
>
> I don't see any reason we wouldn't continue to support it
> Bruce
> On Thu, 22 Oct
> 2015, Mathieu Dubois wrote:
>
> > Hi again,
> >
> > Another advantage of using qcache in my case is that the file names are
> > automatically generated and therefore standard.
> >
> > Is there any risk (particularly for future compatibility) in using
> > qcache? Did anyone had some problem with it?
> >
> > Thanks in advance,
> > Mathieu
> >
> > Le 21/10/2015 18:07, Mathieu Dubois a ?crit :
> >> Hi Doug,
> >>
> >> Thanks for your answer.
> >>
> >> If I understand correctly, the tutorial describes the use of
> >> mris_preproc with a group description file. If the data has not been
> >> cached, it will compute them and stack all the results in a big file
> >> (will it write individual files?) . Of course if the data has been
> >> cached, it will only stack them (this probably result in more disk usage
> >> but that's OK).
> >>
> >> I don't plan to use FreeSurfer's linear model for group analysis (my
> >> goal is to use those data in machine learning algorithms) but other
> >> people at the institute I work for may be interested in that. I think
> >> it's more convenient to have one file per subject (so I can group them
> >> in a more flexible way).
> >>
> >> So I guess I can always run recon-all for each subject with -qcache (I
> >> have read that is safe to do so) in order to generate the data for each
> >> subject (this can easily be distributed across a cluster and compute
> >> several measures). I can then load the data for each subject and people
> >> interested into running FreeSurfer group analysis can also use them. Is
> >> it correct?
> >>
> >> My only concern is: will -qcache be supported in future versions of
> >> FreeSurfer? Couldn't some part of it (like the resampling on the average
> >> subject but no the smoothing) be integrated into -all?
> >>
> >> Mathieu
> >>
> >> Le 21/10/2015 16:37, Douglas Greve a ?crit :
> >>> Hi Mathieu, look at the group analysis tutorial on our wiki. Basically,
> >>> you will run mris_preproc, mri_surf2surf to smooth, then mri_glmfit to
> >>> do the group analysis, then mri_glmfit-sim to do the correction for
> >>> multiple comparisons.
> >>> doug
> >>>
> >>> On 10/21/15 10:15 AM, Mathieu Dubois wrote:
> >>>> Hi,
> >>>>
> >>>> I'm a beginner with freesurfer so I apologize if it's a trivial
> question.
> >>>>
> >>>> I recently run recon-all with the -all on many subjects. As far as I
> can
> >>>> say, all the steps worked. However, the measures on the average brain
> >>>> (output of mris_preproc and friends) were not computed.
> >>>>
> >>>> A colleague told me that he usually re-run recon-all with the -qcache
> >>>> flag to compute those. This seems to work but I don't understand if it
> >>>> is the recommended way to run mris_preproc and why it is not included
> >>>> with -all. Is it possible to get those measures in one call to
> recon-all?
> >>>>
> >>>> I don't think that the issue comes from the data (e.g. that the
> failing
> >>>> of a step stops some branch of the pipeline) because it seems to run
> >>>> correctly with -qcache.
> >>>>
> >>>> I haven't found any help on -qcache and the help of recon-all doesn't
> >>>> mention mris_preproc or mri_surf2surf.
> >>>>
> >>>> Thanks in advance,
> >>>> Mathieu
> >>>> _______________________________________________
> >>>> Freesurfer mailing list
> >>>> Freesurfer@nmr.mgh.harvard.edu
> >>>> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> >>>>
> >>>>
> >>> _______________________________________________
> >>> Freesurfer mailing list
> >>> Freesurfer@nmr.mgh.harvard.edu
> >>> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> >>>
> >>>
> >>> The information in this e-mail is intended only for the person to whom
> it is
> >>> addressed. If you believe this e-mail was sent to you in error and the
> e-mail
> >>> contains patient information, please contact the Partners Compliance
> HelpLine at
> >>> http://www.partners.org/complianceline . If the e-mail was sent to
> you in error
> >>> but does not contain patient information, please contact the sender
> and properly
> >>> dispose of the e-mail.
> >>>
> >> _______________________________________________
> >> Freesurfer mailing list
> >> Freesurfer@nmr.mgh.harvard.edu
> >> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> >
> > _______________________________________________
> > Freesurfer mailing list
> > Freesurfer@nmr.mgh.harvard.edu
> > https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> >
> >
> >
>
> ------------------------------
>
> Message: 7
> Date: Thu, 22 Oct 2015 11:39:22 -0400 (EDT)
> From: Bruce Fischl <fis...@nmr.mgh.harvard.edu>
> Subject: Re: [Freesurfer] Talairach_afd error
> To: Freesurfer support list <freesurfer@nmr.mgh.harvard.edu>
> Message-ID:
>         <alpine.lrh.2.20.1510221138530.19...@gate.nmr.mgh.harvard.edu>
> Content-Type: text/plain; charset="utf-8"
>
> Hi Anna
>
> are the talairach.xfm files generated by the two machines similar?
>
> Bruce
> On Wed,
> 21 Oct 2015, Anna I. Garcia Diaz wrote:
>
> > Dear all,
> > I am having problems running the recon-all process. The error log is
> attached to this e-mail.?
> >
> > This error appears only when I run recon-all in a machine able to
> parallelize preprocesses, however, if I use the same
> > reconstructed oriented image in a machine sent as a normal job directly
> to the terminal, the preprocess runs without
> > any errors and the output looks correct. I have tried to use the
> -notal-check flag as the error log suggests, but it
> > fails anyway.?
> >
> > Since our team is working in a longitudinal study, and the images from
> the other time points have been preprocessed
> > with the parallelizing machine, we are concerned that using the
> non-parallelizing machine could add significant
> > methodological variabilities to our studies, and we would rather be
> consistent with the previous procedures.?
> >
> > Do you have any comments or further suggestions on how we might be able
> to fix this error?
> >
> > Thanks in advance for your time and help
> > Anna Garcia
> >
> >
>
> ------------------------------
>
> Message: 8
> Date: Thu, 22 Oct 2015 11:42:07 -0400
> From: Douglas N Greve <gr...@nmr.mgh.harvard.edu>
> Subject: Re: [Freesurfer] How to compute the measures on the average
>         brain?
> To: freesurfer@nmr.mgh.harvard.edu
> Message-ID: <562903cf.6030...@nmr.mgh.harvard.edu>
> Content-Type: text/plain; charset=windows-1252; format=flowed
>
> No, we will continue to support it
>
> On 10/21/2015 11:13 PM, Mathieu Dubois wrote:
> > Hi again,
> >
> > Another advantage of using qcache in my case is that the file names are
> > automatically generated and therefore standard.
> >
> > Is there any risk (particularly for future compatibility) in using
> > qcache? Did anyone had some problem with it?
> >
> > Thanks in advance,
> > Mathieu
> >
> > Le 21/10/2015 18:07, Mathieu Dubois a ?crit :
> >> Hi Doug,
> >>
> >> Thanks for your answer.
> >>
> >> If I understand correctly, the tutorial describes the use of
> >> mris_preproc with a group description file. If the data has not been
> >> cached, it will compute them and stack all the results in a big file
> >> (will it write individual files?) . Of course if the data has been
> >> cached, it will only stack them (this probably result in more disk usage
> >> but that's OK).
> >>
> >> I don't plan to use FreeSurfer's linear model for group analysis (my
> >> goal is to use those data in machine learning algorithms) but other
> >> people at the institute I work for may be interested in that. I think
> >> it's more convenient to have one file per subject (so I can group them
> >> in a more flexible way).
> >>
> >> So I guess I can always run recon-all for each subject with -qcache (I
> >> have read that is safe to do so) in order to generate the data for each
> >> subject (this can easily be distributed across a cluster and compute
> >> several measures). I can then load the data for each subject and people
> >> interested into running FreeSurfer group analysis can also use them. Is
> >> it correct?
> >>
> >> My only concern is: will -qcache be supported in future versions of
> >> FreeSurfer? Couldn't some part of it (like the resampling on the average
> >> subject but no the smoothing) be integrated into -all?
> >>
> >> Mathieu
> >>
> >> Le 21/10/2015 16:37, Douglas Greve a ?crit :
> >>> Hi Mathieu, look at the group analysis tutorial on our wiki. Basically,
> >>> you will run mris_preproc, mri_surf2surf to smooth, then mri_glmfit to
> >>> do the group analysis, then mri_glmfit-sim to do the correction for
> >>> multiple comparisons.
> >>> doug
> >>>
> >>> On 10/21/15 10:15 AM, Mathieu Dubois wrote:
> >>>> Hi,
> >>>>
> >>>> I'm a beginner with freesurfer so I apologize if it's a trivial
> question.
> >>>>
> >>>> I recently run recon-all with the -all on many subjects. As far as I
> can
> >>>> say, all the steps worked. However, the measures on the average brain
> >>>> (output of mris_preproc and friends) were not computed.
> >>>>
> >>>> A colleague told me that he usually re-run recon-all with the -qcache
> >>>> flag to compute those. This seems to work but I don't understand if it
> >>>> is the recommended way to run mris_preproc and why it is not included
> >>>> with -all. Is it possible to get those measures in one call to
> recon-all?
> >>>>
> >>>> I don't think that the issue comes from the data (e.g. that the
> failing
> >>>> of a step stops some branch of the pipeline) because it seems to run
> >>>> correctly with -qcache.
> >>>>
> >>>> I haven't found any help on -qcache and the help of recon-all doesn't
> >>>> mention mris_preproc or mri_surf2surf.
> >>>>
> >>>> Thanks in advance,
> >>>> Mathieu
> >>>> _______________________________________________
> >>>> Freesurfer mailing list
> >>>> Freesurfer@nmr.mgh.harvard.edu
> >>>> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> >>>>
> >>>>
> >>> _______________________________________________
> >>> Freesurfer mailing list
> >>> Freesurfer@nmr.mgh.harvard.edu
> >>> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> >>>
> >>>
> >>> The information in this e-mail is intended only for the person to whom
> it is
> >>> addressed. If you believe this e-mail was sent to you in error and the
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> >>> contains patient information, please contact the Partners Compliance
> HelpLine at
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> >>>
> >> _______________________________________________
> >> Freesurfer mailing list
> >> Freesurfer@nmr.mgh.harvard.edu
> >> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> > _______________________________________________
> > Freesurfer mailing list
> > Freesurfer@nmr.mgh.harvard.edu
> > https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> >
> >
>
> --
> Douglas N. Greve, Ph.D.
> MGH-NMR Center
> gr...@nmr.mgh.harvard.edu
> Phone Number: 617-724-2358
> Fax: 617-726-7422
>
> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
> FileDrop: https://gate.nmr.mgh.harvard.edu/filedrop2
> www.nmr.mgh.harvard.edu/facility/filedrop/index.html
> Outgoing: ftp://surfer.nmr.mgh.harvard.edu/transfer/outgoing/flat/greve/
>
>
>
> ------------------------------
>
> Message: 9
> Date: Thu, 22 Oct 2015 11:48:26 -0400
> From: Douglas N Greve <gr...@nmr.mgh.harvard.edu>
> Subject: Re: [Freesurfer] normalization of hippocampal volume
> To: freesurfer@nmr.mgh.harvard.edu
> Message-ID: <5629054a.8090...@nmr.mgh.harvard.edu>
> Content-Type: text/plain; charset=euc-kr
>
> I'm not sure what you mean by either of those options. can you explain?
>
> On 10/22/2015 04:18 AM, geschwind2013 wrote:
> > Hi, FS Experts,
> >
> > I?m using version 5.3 and have performed hippo-subfields analysis.
> >
> > To perform the statistics, shall I get the normalized volumes of each
> hippo-subfields?
> > or just to do correction for ICV is enough ?
> >
> > thanks..
> >
> > Hyon
> > _______________________________________________
> > Freesurfer mailing list
> > Freesurfer@nmr.mgh.harvard.edu
> > https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> >
> >
>
> --
> Douglas N. Greve, Ph.D.
> MGH-NMR Center
> gr...@nmr.mgh.harvard.edu
> Phone Number: 617-724-2358
> Fax: 617-726-7422
>
> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
> FileDrop: https://gate.nmr.mgh.harvard.edu/filedrop2
> www.nmr.mgh.harvard.edu/facility/filedrop/index.html
> Outgoing: ftp://surfer.nmr.mgh.harvard.edu/transfer/outgoing/flat/greve/
>
>
>
> ------------------------------
>
> Message: 10
> Date: Thu, 22 Oct 2015 11:50:10 -0400
> From: Douglas N Greve <gr...@nmr.mgh.harvard.edu>
> Subject: Re: [Freesurfer] per analysis with covariates
> To: freesurfer@nmr.mgh.harvard.edu
> Message-ID: <562905b2.6070...@nmr.mgh.harvard.edu>
> Content-Type: text/plain; charset=windows-1252; format=flowed
>
> what do you mean to control age and gender on both lGI and thickness? If
> you have thickness = f(gender,age,lGI), then you control for gender,
> age, and lGI on thickness.
>
> On 10/20/2015 06:20 AM, marica.pad...@libero.it wrote:
> >
> > Hi,
> >
> > I am running a vertex-wise correlation analysis between local
> gyrification (--
> > y) and thickness (--pvr) using as covariates age and gender.
> > I want to control for the effect of age and gender both the lGI and the
> > thickness values. Does the command does this? Or the effect of the
> covariates
> > is only taken into account for the lGI?
> >
> >   Here my command line:
> >
> > mri_glmfit --glmdir left --y lh.lGI.mgh --fsgd fsgd_control.txt --pvr lh.
> > thickness.mgh --C contrast_control.txt --surface fsaverage lh
> >
> > And my contrast:
> >
> > 0 0 0 1  (first 0 for the class, second and third for the 2 covariates).
> >
> > Thanks,
> > Marica
> > _______________________________________________
> > Freesurfer mailing list
> > Freesurfer@nmr.mgh.harvard.edu
> > https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
> >
> >
>
> --
> Douglas N. Greve, Ph.D.
> MGH-NMR Center
> gr...@nmr.mgh.harvard.edu
> Phone Number: 617-724-2358
> Fax: 617-726-7422
>
> Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
> FileDrop: https://gate.nmr.mgh.harvard.edu/filedrop2
> www.nmr.mgh.harvard.edu/facility/filedrop/index.html
> Outgoing: ftp://surfer.nmr.mgh.harvard.edu/transfer/outgoing/flat/greve/
>
>
>
> ------------------------------
>
> _______________________________________________
> Freesurfer mailing list
> Freesurfer@nmr.mgh.harvard.edu
> https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer
>
> End of Freesurfer Digest, Vol 140, Issue 37
> *******************************************
>
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